| Tag | Content |
|---|---|
| Uniprot ID | O88413 |
| Entrez ID | 22158 |
| Genbank protein ID | BAA74752.1; AAC95430.1; AAH60068.1; |
| Genbank nucleotide ID | NM_011657.2 |
| Ensembl protein ID | ENSMUSP00000001562 |
| Ensembl nucleotide ID | ENSMUSG00000001521 |
| Gene name | Tubby-related protein 3 |
| Gene symbol | Tulp3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 11406614 |
| Functional description | Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes. |
| Sequence | MEAARCAPGP RGDSAFDDET LRLRQLKLDN QRALLEKKQR KKRLEPLMVQ PNPEARLRRL 60 KPRGSEEHTP LVDPQMPRSD VILHGIDGPA AFLKPEAQDL ESKPQVLSVG SPAPEEGTEG 120 SADGESPEET APKPDLQEIL QKHGILSSVN YDEEPDKEED EGGNLSSPSA RSEESAAASQ 180 KAASETGASG VTAQQGDAQL GEVENLEDFA YSPAPRGVTV KCKVTRDKKG MDRGLFPTYY 240 MHLEREENRK IFLLAGRKRK KSKTSNYLVS TDPTDLSREG ESYIGKLRSN LMGTKFTVYD 300 HGVNPVKAQG LVEKAHTRQE LAAICYETNV LGFKGPRKMS VIIPGMNMNH ERIPFRPRNE 360 HESLLSKWQN KSMENLIELH NKAPVWNDDT QSYVLNFHGR VTQASVKNFQ IVHGNDPDYI 420 VMQFGRVADD VFTLDYNYPL CALQAFAIGL SSFDSKLACE |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TULP3 | F1N7S0 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | TULP3 | 611832 | F1PNR7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TULP3 | 102170303 | A0A452G8R3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TULP3 | 7289 | O75386 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tulp3 | 22158 | O88413 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TULP3 | H2R7L6 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | 100511196 | A0A480JWW4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TULP3 | 100341264 | G1SUQ3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Tulp3 | F1M656 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001664 | G protein-coupled receptor binding | ISO |
| GO:0019899 | enzyme binding | ISO |
| GO:0035091 | phosphatidylinositol binding | ISS |
| GO:0035091 | phosphatidylinositol binding | ISO |
| GO:0044877 | protein-containing complex binding | ISO |
| GO:0120160 | intraciliary transport particle A binding | ISO |
| GO:0120160 | intraciliary transport particle A binding | ISS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001841 | neural tube formation | IMP |
| GO:0001843 | neural tube closure | IMP |
| GO:0007420 | brain development | IMP |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | ISS |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | ISO |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | IMP |
| GO:0008589 | regulation of smoothened signaling pathway | IMP |
| GO:0009952 | anterior/posterior pattern specification | IMP |
| GO:0021904 | dorsal/ventral neural tube patterning | IMP |
| GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning | IMP |
| GO:0021915 | neural tube development | IMP |
| GO:0021953 | central nervous system neuron differentiation | IMP |
| GO:0031076 | embryonic camera-type eye development | IMP |
| GO:0042733 | embryonic digit morphogenesis | IMP |
| GO:0045879 | negative regulation of smoothened signaling pathway | ISO |
| GO:0045879 | negative regulation of smoothened signaling pathway | IMP |
| GO:0048702 | embryonic neurocranium morphogenesis | IMP |
| GO:0060173 | limb development | IGI |
| GO:0060173 | limb development | IMP |
| GO:0060348 | bone development | IMP |
| GO:0060434 | bronchus morphogenesis | IMP |
| GO:0060831 | smoothened signaling pathway involved in dorsal/ventral neural tube patterning | IMP |
| GO:0061512 | protein localization to cilium | IBA |
| GO:0061512 | protein localization to cilium | IMP |
| GO:0061512 | protein localization to cilium | ISO |
| GO:0061548 | ganglion development | IMP |
| GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | IEA |
| GO:0005634 | nucleus | ISS |
| GO:0005634 | nucleus | ISO |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005730 | nucleolus | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0005929 | cilium | ISO |
| GO:0005929 | cilium | IDA |
| GO:0005929 | cilium | IBA |
| GO:0005930 | axoneme | IDA |
| GO:0097546 | ciliary base | ISO |
| GO:0097731 | 9+0 non-motile cilium | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-5358351 | Signaling by Hedgehog | IEA |
| R-MMU-5610787 | Hedgehog 'off' state | IEA |