| Tag | Content |
|---|---|
| Uniprot ID | P23798 |
| Entrez ID | 22658 |
| Genbank protein ID | BAA14122.1; AAH16419.1; AAL90776.1; AAL90777.1; |
| Genbank nucleotide ID | XM_017314503.1; XM_011248975.2; NM_001163307.1; XM_011248973.2; NM_009545.2; NM_001163308.1; XM_011248972.2; |
| Ensembl protein ID | ENSMUSP00000099437; ENSMUSP00000126967; ENSMUSP00000018681; ENSMUSP00000137517; |
| Ensembl nucleotide ID | ENSMUSG00000018537 |
| Gene name | Polycomb group RING finger protein 2 |
| Gene symbol | Pcgf2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 11290297 |
| Functional description | Transcriptional repressor (PubMed:8521824). Binds specifically to the DNA sequence 5'-GACTNGACT-3' (PubMed:8521824). Has tumor suppressor activity (PubMed:8521824). May play a role in control of cell proliferation and/or neural cell development (Probable). Regulates proliferation of early T progenitor cells by maintaining expression of HES1(PubMed:15728456). Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (PubMed:8625838, PubMed:15183898). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). |
| Sequence | MHRTTRIKIT ELNPHLMCAL CGGYFIDATT IVECLHSFCK TCIVRYLETN KYCPMCDVQV 60 HKTRPLLSIR SDKTLQDIVY KLVPGLFKDE MKRRRDFYAA YPLTEVPNGS NEDRGEVLEQ 120 EKGALGDDEI VSLSIEFYEG VRDREEKKNL TENGDGDKEK TGVRFLRCPA AMTVMHLAKF 180 LRNKMDVPSK YKVEILYEDE PLKEYYTLMD IAYIYPWRRN GPLPLKYRVQ PACKRLTLPT 240 VPTPSEGTNT SGASECESVS DKAPSPATLP ATSSSLPSPA TPSHGSPSSH GPPATHPTSP 300 TPPSTAAGTT TATNGGTSNC LQTPSSTSRG RKMTVNGAPC PP 342 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PCGF2 | 505147 | E1BMR4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PCGF2 | 102174970 | A0A452F706 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PCGF2 | 7703 | P35227 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pcgf2 | 22658 | P23798 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PCGF2 | 454614 | H2QCT2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PCGF2 | A0A287A7A5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Pcgf2 | 287662 | B2RZ82 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003677 | DNA binding | IEA |
| GO:0003682 | chromatin binding | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0046872 | metal ion binding | IEA |
| GO:1990841 | promoter-specific chromatin binding | IBA |
| GO:0097027 | ubiquitin-protein transferase activator activity | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISO |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IGI |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA |
| GO:0001701 | in utero embryonic development | IGI |
| GO:0006342 | chromatin silencing | IBA |
| GO:0009952 | anterior/posterior pattern specification | IGI |
| GO:0009952 | anterior/posterior pattern specification | IMP |
| GO:0016573 | histone acetylation | IGI |
| GO:0036353 | histone H2A-K119 monoubiquitination | ISS |
| GO:0036353 | histone H2A-K119 monoubiquitination | ISO |
| GO:0036353 | histone H2A-K119 monoubiquitination | IBA |
| GO:0048704 | embryonic skeletal system morphogenesis | IGI |
| GO:0048706 | embryonic skeletal system development | IGI |
| GO:0050790 | regulation of catalytic activity | IEA |
| GO:0070301 | cellular response to hydrogen peroxide | IDA |
| GO:2001234 | negative regulation of apoptotic signaling pathway | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000790 | nuclear chromatin | ISO |
| GO:0001739 | sex chromatin | IDA |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005654 | nucleoplasm | TAS |
| GO:0016604 | nuclear body | IDA |
| GO:0031519 | PcG protein complex | ISO |
| GO:0031519 | PcG protein complex | IDA |
| GO:0035102 | PRC1 complex | ISS |
| GO:0035102 | PRC1 complex | ISO |
| GO:0035102 | PRC1 complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-212436 | Generic Transcription Pathway | IEA |
| R-MMU-2990846 | SUMOylation | IEA |
| R-MMU-3108214 | SUMOylation of DNA damage response and repair proteins | IEA |
| R-MMU-3108232 | SUMO E3 ligases SUMOylate target proteins | IEA |
| R-MMU-3899300 | SUMOylation of transcription cofactors | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-4551638 | SUMOylation of chromatin organization proteins | IEA |
| R-MMU-4570464 | SUMOylation of RNA binding proteins | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |
| R-MMU-73857 | RNA Polymerase II Transcription | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| R-MMU-8953750 | Transcriptional Regulation by E2F6 | IEA |
| Pfam ID | Pfam Term |
|---|---|
| PF16207 | RAWUL |