Gene: Serpina6

Basic information

Tag Content
Uniprot ID P31211; Q5M822;
Entrez ID 299270
Genbank protein ID AAH88300.1; EDL81783.1;
Genbank nucleotide ID NM_001009663.1
Ensembl protein ID ENSRNOP00000012500
Ensembl nucleotide ID ENSRNOG00000009438
Gene name Corticosteroid-binding globulin
Gene symbol Serpina6
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Sequence
MSLALYTCLL WLCTSGLWTA QASTNESSNS HRGLAPTNVD FAFNLYQRLV ALNPDKNTLI 60
SPVSISMALA MVSLGSAQTQ SLQSLGFNLT ETSEAEIHQS FQYLNYLLKQ SDTGLEMNMG 120
NAMFLLQKLK LKDSFLADVK QYYESEALAI DFEDWTKASQ QINQHVKDKT QGKIEHVFSD 180
LDSPASFILV NYIFLRGIWE LPFSPENTRE EDFYVNETST VKVPMMVQSG SIGYFRDSVF 240
PCQLIQMDYV GNGTAFFILP DQGQMDTVIA ALSRDTIDRW GKLMTPRQVN LYIPKFSISD 300
TYDLKDMLED LNIKDLLTNQ SDFSGNTKDV PLTLTMVHKA MLQLDEGNVL PNSTNGAPLH 360
LRSEPLDIKF NKPFILLLFD KFTWSSLMMS QVVNPA 396

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSERPINA6513746E1BF81Bos taurusPredictionMore>>
1:1 orthologSERPINA11490838F1PHS2Canis lupus familiarisPredictionMore>>
1:1 orthologSERPINA6102171661A0A452FGE5Capra hircusPredictionMore>>
1:1 orthologSERPINA6866P08185Homo sapiensPublicationMore>>
1:1 orthologSerpina612401Q06770Mus musculusPredictionMore>>
1:1 orthologSERPINA6453131H2Q8V1Pan troglodytesPredictionMore>>
1:1 orthologSerpina6299270P31211Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005615 extracellular space
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005496 steroid binding
GO:0008211 glucocorticoid metabolic process
GO:0010951 negative regulation of endopeptidase activity

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0903 Direct protein sequencing
KW-0325 Glycoprotein
KW-0446 Lipid-binding
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal
KW-0754 Steroid-binding
KW-0813 Transport

Interpro

InterPro ID InterPro Term
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
IPR042178 Serpin_sf_1
IPR042185 Serpin_sf_2

PROSITE

PROSITE ID PROSITE Term
PS00284 SERPIN

Pfam

Pfam ID Pfam Term
PF00079 Serpin