Gene: Csrnp1

Basic information

Tag Content
Uniprot ID P59054; Q3USP7;
Entrez ID 215418
Genbank protein ID BAC16314.1; BAC26661.1; AAH29720.1; BAE24284.1; AAH50066.1;
Genbank nucleotide ID NM_153287.3; XM_006512038.2; XM_006512037.3; XM_006512040.3; XM_011242954.2; XM_006512041.3;
Ensembl protein ID ENSMUSP00000035101; ENSMUSP00000150628; ENSMUSP00000149214;
Ensembl nucleotide ID ENSMUSG00000032515
Gene name Cysteine/serine-rich nuclear protein 1
Gene symbol Csrnp1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 17143286
Functional description Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. May have a tumor-suppressor function. May play a role in apoptosis.
Sequence
MTGLLKRKFD QLEEDDSSSS SSSSFSSRLS LSSFPASSAS PAWNSDEEGP GGQAPQSDQD 60
SCGLQSFTPP SILKRAPRER PGHVAFNGIT VYYFPRCQGF TSVPSRGGCT LGMASRHSTC 120
RLFSLAEFTQ EQVRARREKL RRRLKEEKLE MLRWKFSVAG VPESGAGVPL TADAIDDASV 180
EEDLAVAVAN GRLEEANFLQ PHPPRQRRAL LRASGVRRID REEKRELQVL RQSREDCGCH 240
CDGVCDPETC SCSLAGIKCQ MDHTSFPCGC CREGCENPNG RVEFNQTRVQ THFIHTLTRL 300
QMEQGAESLG DLESPVEDTP VEQAALSPFP PSKPPVSSEL GDSSCSSDMT DSSTTLSSGS 360
SEPPNHPAHP SLPGPSFRSG VDEDSLEQIL NFSDSDLGIE EEEEEGGGVG NLDNLSCFHL 420
ADIFGTGDPG SLASWTHSQS GSSLASGILD ENANLDASCF LNSGLGGLRE GSLPGSSGSP 480
EGDAVQSSSW DLSLSSCDSF ELLQALPDYS LGPHYTSRRV SGSPDSLETF HPLPSFSPPR 540
DASTCFLESL VGLSEPVTEV LAPLLESQFE DAALAPLLEP VPV 583

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCSRNP1F1MDN9Bos taurusPredictionMore>>
1:1 orthologCSRNP1485596E2RJ34Canis lupus familiarisPredictionMore>>
1:1 orthologCSRNP1102186348A0A452FLI0Capra hircusPredictionMore>>
1:1 orthologCSRNP164651Q96S65Homo sapiensPredictionMore>>
1:1 orthologCsrnp1215418P59054CPOMus musculusPublicationMore>>
1:1 orthologCSRNP1470794K7BVU1Pan troglodytesPredictionMore>>
1:1 orthologCSRNP1100519275F1SJR3Sus scrofaPredictionMore>>
1:1 orthologCSRNP1G1TKZ1Oryctolagus cuniculusPredictionMore>>
1:1 orthologCsrnp1363165D4AAK3Rattus norvegicusPredictionMore>>
1:1 orthologcsrnp1bF1QNJ1Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specificIDA
GO:0003700 DNA-binding transcription factor activityIDA
GO:0043565 sequence-specific DNA bindingIDA

GO:Biological Process

GO ID GO Term Evidence
GO:0006355 regulation of transcription, DNA-templatedIMP
GO:0006915 apoptotic processIEA
GO:0009791 post-embryonic developmentIMP
GO:0045944 positive regulation of transcription by RNA polymerase IIIDA
GO:0048008 platelet-derived growth factor receptor signaling pathwayIMP
GO:0048705 skeletal system morphogenesisIMP
GO:0060021 roof of mouth developmentIMP
GO:0060325 face morphogenesisIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusIDA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0010 Activator
KW-0053 Apoptosis
KW-0238 DNA-binding
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0804 Transcription
KW-0805 Transcription regulation

Interpro

InterPro ID InterPro Term
IPR031972 CSRNP_N
IPR023260 Cys/Ser-rich_nuc_prot

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF16019 CSRNP_N