| Tag | Content |
|---|---|
| Uniprot ID | P62509; O75454; O96021; Q8CHC9; Q9R1F3; |
| Entrez ID | 26381 |
| Genbank protein ID | BAC41450.1; AAH82324.1; AAD48369.1; BAC35120.1; |
| Genbank nucleotide ID | XM_006497165.3; NM_001243792.1; XM_006497164.3; NM_011935.3; XM_006497170.1; XM_006497167.3; |
| Ensembl protein ID | ENSMUSP00000106563; ENSMUSP00000027906; ENSMUSP00000106564; |
| Ensembl nucleotide ID | ENSMUSG00000026610 |
| Gene name | Estrogen-related receptor gamma |
| Gene symbol | Esrrg |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle. |
| Sequence | MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT DSVNHHSPGG 60 SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL YDDCSSTIVE DPQTKCEYML 120 NSMPKRLCLV CGDIASGYHY GVASCEACKA FFKRTIQGNI EYSCPATNEC EITKRRRKSC 180 QACRFMKCLK VGMLKEGVRL DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH 240 LLVAEPEKIY AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL 300 LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL QLVKKYKSMK 360 LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ DYEAGQHMED PRRAGKMLMT 420 LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF LEMLEAKV 458 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ESRRG | 478961 | J9NWD9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ESRRG | A0A452FEX0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ESRRG | 2104 | P62508 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Esrrg | 26381 | P62509 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | ESRRG | 457738 | A0A2I3T916 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ESRRG | 100355568 | G1SEH2 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Esrrg | 360896 | P62510 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IMP |
| GO:0003677 | DNA binding | NAS |
| GO:0003707 | steroid hormone receptor activity | IEA |
| GO:0004879 | nuclear receptor activity | NAS |
| GO:0005496 | steroid binding | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0005516 | calmodulin binding | NAS |
| GO:0008270 | zinc ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | ISS |
| GO:0006355 | regulation of transcription, DNA-templated | ISO |
| GO:0006355 | regulation of transcription, DNA-templated | NAS |
| GO:0007275 | multicellular organism development | NAS |
| GO:0043401 | steroid hormone mediated signaling pathway | IEA |
| GO:0045893 | positive regulation of transcription, DNA-templated | IDA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IMP |
| GO:0048384 | retinoic acid receptor signaling pathway | IEA |
| GO:0120162 | positive regulation of cold-induced thermogenesis | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | NAS |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-212436 | Generic Transcription Pathway | IEA |
| R-MMU-383280 | Nuclear Receptor transcription pathway | IEA |
| R-MMU-73857 | RNA Polymerase II Transcription | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0007 | Acetylation |
| KW-0010 | Activator |
| KW-0025 | Alternative splicing |
| KW-0238 | DNA-binding |
| KW-1017 | Isopeptide bond |
| KW-0479 | Metal-binding |
| KW-0539 | Nucleus |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0804 | Transcription |
| KW-0805 | Transcription regulation |
| KW-0832 | Ubl conjugation |
| KW-0862 | Zinc |
| KW-0863 | Zinc-finger |