| Tag | Content |
|---|---|
| Uniprot ID | P63166; P55856; Q3TX92; Q93068; |
| Entrez ID | 22218 |
| Genbank protein ID | AAH83158.1; AAC39959.1; BAB27379.1; AAH82566.1; BAC40739.1; BAE35024.1; BAB22172.1; |
| Genbank nucleotide ID | NM_009460.2 |
| Ensembl protein ID | ENSMUSP00000088935 |
| Ensembl nucleotide ID | ENSMUSG00000026021 |
| Gene name | Small ubiquitin-related modifier 1 |
| Gene symbol | Sumo1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E13.5, E14.5 |
| Data sources | Manually collected |
| Reference | 16990542 |
| Functional description | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (By similarity). |
| Sequence | MSDQEAKPST EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES YCQRQGVPMN 60 SLRFLFEGQR IADNHTPKEL GMEEEDVIEV YQEQTGGHST V 101 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SUMO1 | 614967 | Q5E9D1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SUMO1 | 478874 | E2RR10 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SUMO1 | A0A452DXV1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SUMO1 | 7341 | P63165 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Sumo1 | 22218 | P63166 | CPO | E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SUMO1 | A0A2I3SHN2 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | SUMO1 | 100127139 | A7WLH8 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Sumo1 | 301442 | Q5I0H3 | Rattus norvegicus | Prediction | More>> |
| Gene symbol | Significant Variants/SNPS | Methods | PubMed ID |
|---|---|---|---|
| SUMO1 | rs2350358G>C | PCR-RFLP | 20544801 |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001222 | transcription corepressor binding | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0008022 | protein C-terminus binding | ISO |
| GO:0008134 | transcription factor binding | IMP |
| GO:0008134 | transcription factor binding | IPI |
| GO:0015459 | potassium channel regulator activity | ISS |
| GO:0015459 | potassium channel regulator activity | ISO |
| GO:0019899 | enzyme binding | ISO |
| GO:0030674 | protein binding, bridging | ISO |
| GO:0031386 | protein tag | IBA |
| GO:0031625 | ubiquitin protein ligase binding | ISS |
| GO:0031625 | ubiquitin protein ligase binding | ISO |
| GO:0035259 | glucocorticoid receptor binding | ISO |
| GO:0044388 | small protein activating enzyme binding | ISO |
| GO:0044389 | ubiquitin-like protein ligase binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IDA |
| GO:0016925 | protein sumoylation | ISS |
| GO:0016925 | protein sumoylation | ISO |
| GO:0016925 | protein sumoylation | IMP |
| GO:0016925 | protein sumoylation | IDA |
| GO:0016925 | protein sumoylation | IBA |
| GO:0030578 | PML body organization | IMP |
| GO:0031334 | positive regulation of protein-containing complex assembly | ISO |
| GO:0031647 | regulation of protein stability | IMP |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | ISO |
| GO:0034605 | cellular response to heat | ISS |
| GO:0034605 | cellular response to heat | ISO |
| GO:0043392 | negative regulation of DNA binding | ISO |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity | ISO |
| GO:0045759 | negative regulation of action potential | ISS |
| GO:0045759 | negative regulation of action potential | ISO |
| GO:0045892 | negative regulation of transcription, DNA-templated | ISO |
| GO:0050821 | protein stabilization | ISO |
| GO:0060021 | roof of mouth development | IMP |
| GO:0071276 | cellular response to cadmium ion | ISS |
| GO:0071276 | cellular response to cadmium ion | ISO |
| GO:0086004 | regulation of cardiac muscle cell contraction | IMP |
| GO:0090204 | protein localization to nuclear pore | IMP |
| GO:1901896 | positive regulation of ATPase-coupled calcium transmembrane transporter activity | IMP |
| GO:1902260 | negative regulation of delayed rectifier potassium channel activity | ISS |
| GO:1902260 | negative regulation of delayed rectifier potassium channel activity | ISO |
| GO:1903169 | regulation of calcium ion transmembrane transport | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001650 | fibrillar center | ISO |
| GO:0001741 | XY body | ISO |
| GO:0001741 | XY body | IDA |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005730 | nucleolus | ISO |
| GO:0005829 | cytosol | TAS |
| GO:0005886 | plasma membrane | ISS |
| GO:0005886 | plasma membrane | ISO |
| GO:0016604 | nuclear body | ISO |
| GO:0016604 | nuclear body | IDA |
| GO:0016605 | PML body | ISS |
| GO:0016605 | PML body | ISO |
| GO:0016605 | PML body | TAS |
| GO:0016607 | nuclear speck | IEA |
| GO:0030425 | dendrite | ISO |
| GO:0031510 | SUMO activating enzyme complex | ISO |
| GO:0031965 | nuclear membrane | ISO |
| GO:0045202 | synapse | ISO |
| GO:0097165 | nuclear stress granule | ISS |
| GO:0097165 | nuclear stress granule | ISO |
| GO:0000792 | heterochromatin | ISO |
| GO:0008076 | voltage-gated potassium channel complex | ISS |
| GO:0008076 | voltage-gated potassium channel complex | ISO |
| GO:0016605 | PML body | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1280215 | Cytokine Signaling in Immune system | IEA |
| R-MMU-1640170 | Cell Cycle | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-212436 | Generic Transcription Pathway | IEA |
| R-MMU-2990846 | SUMOylation | IEA |
| R-MMU-3065676 | SUMO is conjugated to E1 (UBA2:SAE1) | IEA |
| R-MMU-3065678 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) | IEA |
| R-MMU-3065679 | SUMO is proteolytically processed | IEA |
| R-MMU-3108214 | SUMOylation of DNA damage response and repair proteins | IEA |
| R-MMU-3108232 | SUMO E3 ligases SUMOylate target proteins | IEA |
| R-MMU-3215018 | Processing and activation of SUMO | IEA |
| R-MMU-3232118 | SUMOylation of transcription factors | IEA |
| R-MMU-3232142 | SUMOylation of ubiquitinylation proteins | IEA |
| R-MMU-3899300 | SUMOylation of transcription cofactors | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-4085377 | SUMOylation of SUMOylation proteins | IEA |
| R-MMU-4090294 | SUMOylation of intracellular receptors | IEA |
| R-MMU-4551638 | SUMOylation of chromatin organization proteins | IEA |
| R-MMU-4570464 | SUMOylation of RNA binding proteins | IEA |
| R-MMU-4615885 | SUMOylation of DNA replication proteins | IEA |
| R-MMU-4655427 | SUMOylation of DNA methylation proteins | IEA |
| R-MMU-4755510 | SUMOylation of immune response proteins | IEA |
| R-MMU-5693532 | DNA Double-Strand Break Repair | IEA |
| R-MMU-5693538 | Homology Directed Repair | IEA |
| R-MMU-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | IEA |
| R-MMU-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | IEA |
| R-MMU-5693571 | Nonhomologous End-Joining (NHEJ) | IEA |
| R-MMU-5693606 | DNA Double Strand Break Response | IEA |
| R-MMU-5693607 | Processing of DNA double-strand break ends | IEA |
| R-MMU-5696395 | Formation of Incision Complex in GG-NER | IEA |
| R-MMU-5696398 | Nucleotide Excision Repair | IEA |
| R-MMU-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |
| R-MMU-69473 | G2/M DNA damage checkpoint | IEA |
| R-MMU-69481 | G2/M Checkpoints | IEA |
| R-MMU-69620 | Cell Cycle Checkpoints | IEA |
| R-MMU-73857 | RNA Polymerase II Transcription | IEA |
| R-MMU-73894 | DNA Repair | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| R-MMU-877300 | Interferon gamma signaling | IEA |
| R-MMU-877312 | Regulation of IFNG signaling | IEA |
| R-MMU-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | IEA |
| R-MMU-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | IEA |
| R-MMU-913531 | Interferon Signaling | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50053 | UBIQUITIN_2 |
| Pfam ID | Pfam Term |
|---|---|
| PF11976 | Rad60-SLD |