| Tag |
Content |
| Uniprot ID |
Q5E9D1; Q3ZC68;
|
| Entrez ID |
614967 |
| Genbank protein ID |
AAI02885.1; AAX09006.1; |
| Genbank nucleotide ID |
NM_001035458.1 |
| Ensembl protein ID |
|
| Ensembl nucleotide ID |
|
|
Gene name
|
Small ubiquitin-related modifier 1 |
|
Gene symbol
|
SUMO1 |
|
Organism
|
Bos taurus |
|
NCBI taxa ID
|
9913 |
|
Cleft type
|
|
|
Developmental stage
|
|
|
Data sources
|
Homology search |
| Reference |
|
|
Functional description
|
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3. |
Sequence
| MSDQEAKPST EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES YCQRQGVPMN 60
SLRFLFEGQR IADNHTPKEL GMEEEDVIEV YQEQTGGHST V 101 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
