| Tag | Content |
|---|---|
| Uniprot ID | Q5I0H3 |
| Entrez ID | 301442 |
| Genbank protein ID | AAH88322.1 |
| Genbank nucleotide ID | NM_001009672.1 |
| Ensembl protein ID | ENSRNOP00000022048 |
| Ensembl nucleotide ID | ENSRNOG00000016133 |
| Gene name | Small ubiquitin-related modifier 1 |
| Gene symbol | Sumo1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3. |
| Sequence | MSDQEAKPST EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES YCQRQGVPMN 60 SLRFLFEGQR IADNHTPKEL GMEEEDVIEV YQEQTGGHST V 101 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SUMO1 | 614967 | Q5E9D1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SUMO1 | 478874 | E2RR10 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SUMO1 | A0A452DXV1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | SUMO1 | 7341 | P63165 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Sumo1 | 22218 | P63166 | CPO | E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SUMO1 | A0A2I3SHN2 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | SUMO1 | 100127139 | A7WLH8 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Sumo1 | 301442 | Q5I0H3 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0030425 | dendrite |
| GO:0001650 | fibrillar center |
| GO:0016604 | nuclear body |
| GO:0031965 | nuclear membrane |
| GO:0016607 | nuclear speck |
| GO:0097165 | nuclear stress granule |
| GO:0005634 | nucleus |
| GO:0005886 | plasma membrane |
| GO:0016605 | PML body |
| GO:0031510 | SUMO activating enzyme complex |
| GO:0045202 | synapse |
| GO:0008076 | voltage-gated potassium channel complex |
| GO:0001741 | XY body |
| GO:0019899 | enzyme binding |
| GO:0035259 | glucocorticoid receptor binding |
| GO:0015459 | potassium channel regulator activity |
| GO:0008022 | protein C-terminus binding |
| GO:0031386 | protein tag |
| GO:0030674 | protein-macromolecule adaptor activity |
| GO:0044388 | small protein activating enzyme binding |
| GO:0001222 | transcription corepressor binding |
| GO:0008134 | transcription factor binding |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0044389 | ubiquitin-like protein ligase binding |
| GO:1990381 | ubiquitin-specific protease binding |
| GO:0071276 | cellular response to cadmium ion |
| GO:0034605 | cellular response to heat |
| GO:0045759 | negative regulation of action potential |
| GO:1902260 | negative regulation of delayed rectifier potassium channel activity |
| GO:0043392 | negative regulation of DNA binding |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0030578 | PML body organization |
| GO:1901896 | positive regulation of ATPase-coupled calcium transmembrane transporter activity |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO:0031334 | positive regulation of protein-containing complex assembly |
| GO:0090204 | protein localization to nuclear pore |
| GO:0050821 | protein stabilization |
| GO:0016925 | protein sumoylation |
| GO:1903169 | regulation of calcium ion transmembrane transport |
| GO:0086004 | regulation of cardiac muscle cell contraction |
| GO:0031647 | regulation of protein stability |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0060021 | roof of mouth development |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50053 | UBIQUITIN_2 |
| Pfam ID | Pfam Term |
|---|---|
| PF11976 | Rad60-SLD |