Gene: Gas1

Basic information

Tag Content
Uniprot ID Q01721
Entrez ID 14451
Genbank protein ID CAA46256.1; AAH58628.1;
Genbank nucleotide ID NM_008086.2
Ensembl protein ID ENSMUSP00000064555
Ensembl nucleotide ID ENSMUSG00000052957
Gene name Growth arrest-specific protein 1
Gene symbol Gas1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage E13.0, E14.5
Data sources Manually collected
Reference 17525797
Functional description Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
Sequence
MLAALLGGAG ARTGTLPGAL LCLMALLQLL CSAPRGSGLA HGRRLICWQA LLQCQGEPDC 60
SYAYSQYAEA CAPVLAQRGG ADAPGPAGAF PASAASSPRW RCPSHCISAL IQLNHTRRGP 120
ALEDCDCAQD EHCRSTKRAI EPCLPRTSSV GPGAGAGSVM GCTEARRRCD RDSRCNLALS 180
RYLAYCGKLF NGLRCTDECR AVIEDMLAVP KAALLNDCVC DGLERPICES VKENMARLCF 240
GPDASNGPGS SGSDGGLDDY YDEEYDDEQR AGAAGGEQPL DDDDGLARPG GGAAAAGGRG 300
DLPHGPGRRS SSSGSGGHWA NRSAWTPFAC LLLLLLLLLG SHL 343

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

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Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologGAS1A0A452DUH3Capra hircusPredictionMore>>
1:1 orthologGAS12619P54826Homo sapiensPredictionMore>>
1:1 orthologGas114451Q01721CPOE13.0, E14.5Mus musculusPublicationMore>>
1:1 orthologGAS1A0A2I3SJR6Pan troglodytesPredictionMore>>
1:1 orthologGas1683470M0RBH9Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI

GO:Biological Process

GO ID GO Term Evidence
GO:0002053 positive regulation of mesenchymal cell proliferationIMP
GO:0007050 cell cycle arrestTAS
GO:0007411 axon guidanceIMP
GO:0008284 positive regulation of cell population proliferationIMP
GO:0008589 regulation of smoothened signaling pathwayIMP
GO:0009953 dorsal/ventral pattern formationIMP
GO:0010955 negative regulation of protein processingISS
GO:0010955 negative regulation of protein processingISO
GO:0012501 programmed cell deathIDA
GO:0021587 cerebellum morphogenesisIMP
GO:0021904 dorsal/ventral neural tube patterningIMP
GO:0021904 dorsal/ventral neural tube patterningIGI
GO:0030308 negative regulation of cell growthIDA
GO:0042473 outer ear morphogenesisIMP
GO:0042474 middle ear morphogenesisIMP
GO:0042476 odontogenesisIMP
GO:0042733 embryonic digit morphogenesisIGI
GO:0042733 embryonic digit morphogenesisIMP
GO:0043010 camera-type eye developmentIMP
GO:0043066 negative regulation of apoptotic processIMP
GO:0043066 negative regulation of apoptotic processIDA
GO:0045165 cell fate commitmentIMP
GO:0045165 cell fate commitmentIGI
GO:0045879 negative regulation of smoothened signaling pathwayIDA
GO:0045880 positive regulation of smoothened signaling pathwayIDA
GO:0045880 positive regulation of smoothened signaling pathwayIMP
GO:0045930 negative regulation of mitotic cell cycleISO
GO:0045930 negative regulation of mitotic cell cycleISS
GO:0045930 negative regulation of mitotic cell cycleIBA
GO:0048589 developmental growthIMP
GO:0048592 eye morphogenesisIMP
GO:0048598 embryonic morphogenesisIGI
GO:0048598 embryonic morphogenesisIMP
GO:0048701 embryonic cranial skeleton morphogenesisIGI
GO:0048701 embryonic cranial skeleton morphogenesisIMP
GO:0048706 embryonic skeletal system developmentIGI
GO:0048706 embryonic skeletal system developmentIMP
GO:0050679 positive regulation of epithelial cell proliferationIMP
GO:0050680 negative regulation of epithelial cell proliferationIMP
GO:0060021 roof of mouth developmentIMP
GO:0060628 regulation of ER to Golgi vesicle-mediated transportISS
GO:0060628 regulation of ER to Golgi vesicle-mediated transportISO
GO:1902807 negative regulation of cell cycle G1/S phase transitionNAS
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIDA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005886 plasma membraneISO
GO:0005886 plasma membraneIDA
GO:0005886 plasma membraneIBA
GO:0016020 membraneIDA
GO:0046658 anchored component of plasma membraneIDA
GO:0046658 anchored component of plasma membraneISS

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-162582 Signal TransductionIEA
R-MMU-5358351 Signaling by HedgehogIEA
R-MMU-5632681 Ligand-receptor interactionsIEA
R-MMU-5632684 Hedgehog 'on' stateIEA
R-MMU-5635838 Activation of SMOIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0131 Cell cycle
KW-1003 Cell membrane
KW-0325 Glycoprotein
KW-0336 GPI-anchor
KW-0338 Growth arrest
KW-0449 Lipoprotein
KW-0472 Membrane
KW-1185 Reference proteome
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR039596 GAS1
IPR016017 GDNF/GAS1

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF02351 GDNF

Protein-protein interaction

Protein-miRNA interaction