| Tag | Content |
|---|---|
| Uniprot ID | Q0P5A3 |
| Entrez ID | 616052 |
| Genbank protein ID | AAI20307.1 |
| Genbank nucleotide ID | XM_005222244.3; XM_005222243.3; NM_001078056.1; |
| Ensembl protein ID | ENSBTAP00000071714; ENSBTAP00000026427; |
| Ensembl nucleotide ID | ENSBTAG00000019836 |
| Gene name | GSK3B-interacting protein |
| Gene symbol | GSKIP |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (By similarity). |
| Sequence | METDCNPMEL SGVSGFEEEA ELNGFEGTDM KDMRLEAEAV VNDVLFAVNT MFVSKTLRCA 60 DDVAYINVET RERNRYCLEL TEAGLRVVGY AFDQVDDHLQ TPYHETVYSL LDTLSPAYRE 120 AFGNALLQRL EALKREGQS 139 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
Protein disorder visualization from D2P2 is currently unavailable.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GSKIP | 616052 | Q0P5A3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GSKIP | 611079 | E2RIF8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GSKIP | 102175902 | A0A452EEJ4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GSKIP | 51527 | Q9P0R6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gskip | 66787 | Q8BGR8 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GSKIP | 453144 | H2Q8W2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GSKIP | 100154584 | A0A481B832 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Gskip | 362778 | A0A0H2UHD3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | gskip | F1R0B7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0034237 | protein kinase A regulatory subunit binding |
| GO:0019901 | protein kinase binding |
| GO:0004860 | protein kinase inhibitor activity |
| GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| GO:0006469 | negative regulation of protein kinase activity |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:0030111 | regulation of Wnt signaling pathway |
| Pfam ID | Pfam Term |
|---|---|
| PF05303 | DUF727 |