| Tag |
Content |
| Uniprot ID |
Q0P5A3
|
| Entrez ID |
616052 |
| Genbank protein ID |
AAI20307.1 |
| Genbank nucleotide ID |
XM_005222244.3; XM_005222243.3; NM_001078056.1; |
| Ensembl protein ID |
ENSBTAP00000071714; ENSBTAP00000026427; |
| Ensembl nucleotide ID |
ENSBTAG00000019836 |
|
Gene name
|
GSK3B-interacting protein |
|
Gene symbol
|
GSKIP |
|
Organism
|
Bos taurus |
|
NCBI taxa ID
|
9913 |
|
Cleft type
|
|
|
Developmental stage
|
|
|
Data sources
|
Homology search |
| Reference |
|
|
Functional description
|
A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (By similarity). |
Sequence
| METDCNPMEL SGVSGFEEEA ELNGFEGTDM KDMRLEAEAV VNDVLFAVNT MFVSKTLRCA 60
DDVAYINVET RERNRYCLEL TEAGLRVVGY AFDQVDDHLQ TPYHETVYSL LDTLSPAYRE 120
AFGNALLQRL EALKREGQS 139 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
