| Tag | Content |
|---|---|
| Uniprot ID | Q8BGR8; Q8CDW3; Q8K2G9; |
| Entrez ID | 66787 |
| Genbank protein ID | AAH31494.1; BAC26470.1; BAC31325.1; BAC37748.1; |
| Genbank nucleotide ID | NM_178613.3 |
| Ensembl protein ID | ENSMUSP00000057939 |
| Ensembl nucleotide ID | ENSMUSG00000044715 |
| Gene name | GSK3B-interacting protein |
| Gene symbol | Gskip |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 26582204 |
| Functional description | A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (PubMed:26582204). |
| Sequence | METDYNPVEL SSMSGFEEGS ELNGFEGADM KDMQLEAEAV VNDVLFAVNH MFVSKSMPCA 60 DDVAYINVET KERNRYCLEL TEAGLRVVGY AFDQVEDHLQ TPYHETVYSL LDTLSPAYRE 120 AFGNALLQRL EALKRDGQS 139 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GSKIP | 616052 | Q0P5A3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GSKIP | 611079 | E2RIF8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GSKIP | 102175902 | A0A452EEJ4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GSKIP | 51527 | Q9P0R6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gskip | 66787 | Q8BGR8 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GSKIP | 453144 | H2Q8W2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GSKIP | 100154584 | A0A481B832 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Gskip | 362778 | A0A0H2UHD3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | gskip | F1R0B7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004860 | protein kinase inhibitor activity | ISS |
| GO:0004860 | protein kinase inhibitor activity | ISO |
| GO:0019901 | protein kinase binding | ISO |
| GO:0034237 | protein kinase A regulatory subunit binding | ISO |
| GO:0051018 | protein kinase A binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006469 | negative regulation of protein kinase activity | ISS |
| GO:0006469 | negative regulation of protein kinase activity | ISO |
| GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | ISS |
| GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | ISO |
| GO:0030111 | regulation of Wnt signaling pathway | ISS |
| GO:0030111 | regulation of Wnt signaling pathway | ISO |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | ISS |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISS |
| GO:0005634 | nucleus | ISO |
| GO:0005737 | cytoplasm | ISS |
| GO:0005737 | cytoplasm | ISO |
| GO:0048471 | perinuclear region of cytoplasm | ISS |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF05303 | DUF727 |