Gene: Pdss2

Basic information

Tag Content
Uniprot ID Q33DR3; B2RWA7; B2RWF3; Q3USU6; Q9D3K7;
Entrez ID 71365
Genbank protein ID AAI47695.1; BAB30693.1; AAI47753.1; AAI47754.1; BAE24234.1; BAE48218.1; AAI47694.1;
Genbank nucleotide ID NM_027772.2; NM_001168289.1;
Ensembl protein ID ENSMUSP00000124864; ENSMUSP00000093393;
Ensembl nucleotide ID ENSMUSG00000038240
Gene name Decaprenyl-diphosphate synthase subunit 2
Gene symbol Pdss2
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 21871565
Functional description Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.
Sequence
MSLRQLLLRL SGYLGASGPP SRHWWYFRSL DSISSAGSWR GRSSRSPAHW NQVVSEAEKI 60
VGYPASFMSL RCLLSDELSN IAMQVRKLVG TGHPLLTTAR ALVHDSRHNL QLRGLVVLLI 120
SKAAGPSTRN AACQNYDMVS GVYSCQRSLA EITELIHTAL LVHRGIVNLS ELQSSDGPLK 180
DMQFGNKIAI LSGDFLLANA CNGLALLQNT KVVELLSSAL MDLVHGVYQE NSASTKENSI 240
PDDIGISTWK EQTFLSHCAL LAKSCQAAME LAKHDAAVQD MAFQYGKHMA MSHKINADLQ 300
PFIKDKASDS KTFNLNSAPV VLHQEFLGRD LWIKQIGEAQ EKGSLNYSKL RETIKAGKGV 360
TSAIDLCRYH GNKALEALES FPPSEARSAL ENIVFAVTRF S 401

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPDSS2521115A6QR05Bos taurusPredictionMore>>
1:1 orthologPDSS2481950A0A5F4DM97Canis lupus familiarisPredictionMore>>
1:1 orthologPDSS2102191138A0A452EPD3Capra hircusPredictionMore>>
1:1 orthologPDSS2100072062A0A3Q2LJH9Equus caballusPredictionMore>>
1:1 orthologPDSS257107Q86YH6Homo sapiensPredictionMore>>
1:1 orthologPdss271365Q33DR3CPOMus musculusPublicationMore>>
1:1 orthologPDSS2462912H2QTH8Pan troglodytesPredictionMore>>
1:1 orthologPDSS2100312977D0G786Sus scrofaPredictionMore>>
1:1 orthologPDSS2A0A5F9DMW0Oryctolagus cuniculusPredictionMore>>
1:1 orthologPdss2365592Q5U2R1Rattus norvegicusPredictionMore>>
1:1 orthologpdss2B7ZD86Danio rerioPredictionMore>>

Other genetic variants/mutations

loading...

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI
GO:0046982 protein heterodimerization activityIDA
GO:0000010 trans-hexaprenyltranstransferase activityISO
GO:0000010 trans-hexaprenyltranstransferase activityIDA
GO:0050347 trans-octaprenyltranstransferase activityIDA

GO:Biological Process

GO ID GO Term Evidence
GO:0006744 ubiquinone biosynthetic processIEA
GO:0006744 ubiquinone biosynthetic processISO
GO:0006744 ubiquinone biosynthetic processIDA
GO:0008299 isoprenoid biosynthetic processISO
GO:0008299 isoprenoid biosynthetic processIDA
GO:0050878 regulation of body fluid levelsIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005739 mitochondrionHDA
GO:0005829 cytosolISO
GO:1990234 transferase complexISO
GO:1990234 transferase complexIDA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1430728 MetabolismIEA
R-MMU-196854 Metabolism of vitamins and cofactorsIEA
R-MMU-2142789 Ubiquinol biosynthesisIEA
R-MMU-8978934 Metabolism of cofactorsIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0414 Isoprene biosynthesis
KW-0496 Mitochondrion
KW-1185 Reference proteome
KW-0808 Transferase
KW-0831 Ubiquinone biosynthesis

Interpro

InterPro ID InterPro Term
IPR008949 Isoprenoid_synthase_dom_sf
IPR000092 Polyprenyl_synt

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF00348 polyprenyl_synt

Protein-miRNA interaction