Gene: Tent5c

Basic information

Tag Content
Uniprot ID Q5SSF7; Q0P629; Q80XL2; Q9CUN7;
Entrez ID 74645
Genbank protein ID AAH46309.1; AAI20720.1; AAI20718.1; BAB29768.1; AAH37072.1;
Genbank nucleotide ID XM_006502212.3; NM_001142952.1;
Ensembl protein ID ENSMUSP00000056872
Ensembl nucleotide ID ENSMUSG00000044468
Gene name Terminal nucleotidyltransferase 5C
Gene symbol Tent5c
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 27626380
Functional description Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death.
Sequence
MAEEGSSTKD SESFSVLNWD QVSRLHEVLT EVVPIHGRGN FPTLEITLKD IVQTVRGRLE 60
EAGINVQDVR LNGSAAGHVL VKDNGLGCKD LDLIFHVALP TEAEFQLVRD VVLCSLLNFL 120
PEGVNKLKIS PVTLKEAYVQ KLVKVCTDTD RWSLISLSNK NGRNVELKFV DSIRRQFEFS 180
VDSFQIILDS LLFFYDCSGN PISEHFHPTV IGESMYGDFE EAFDHLQNRL IATKNPEEIR 240
GGGLLKYSNL LVRDFRPADQ EEIKTLERYM CSRFFIDFPD ILEQQRKLET YLQNHFSDEE 300
RSKYDYLMIL RRVVNESTVC LMGHERRQTL NLISLLALRV LAEQNIIPSA TNVTCYYQPA 360
PYVSDGNFNN YYIAHPPITY SQPYPTWLPC N 391

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTENT5C102178682A0A452DRJ3Capra hircusPredictionMore>>
1:1 orthologTENT5C100059755F7DFD9Equus caballusPredictionMore>>
1:1 orthologTENT5C54855Q5VWP2Homo sapiensPredictionMore>>
1:1 orthologTent5c74645Q5SSF7CPOMus musculusPublicationMore>>
1:1 orthologTENT5C469434G2HIG9Pan troglodytesPredictionMore>>
1:1 orthologTENT5C100525341A0A287AN43Sus scrofaPredictionMore>>
1:1 orthologTent5c310721Q5XIV0Rattus norvegicusPredictionMore>>
1:1 orthologtent5cB0V2X8Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0003723 RNA bindingIEA
GO:1990817 RNA adenylyltransferase activityISS
GO:1990817 RNA adenylyltransferase activityISO
GO:1990817 RNA adenylyltransferase activityIMP

GO:Biological Process

GO ID GO Term Evidence
GO:0001701 in utero embryonic developmentIMP
GO:0048255 mRNA stabilizationISS
GO:0048255 mRNA stabilizationISO
GO:0048255 mRNA stabilizationIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusISS
GO:0005634 nucleusISO
GO:0005737 cytoplasmISS
GO:0005737 cytoplasmISO
GO:0005737 cytoplasmIDA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0963 Cytoplasm
KW-0548 Nucleotidyltransferase
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0694 RNA-binding
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR012937 TET5

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF07984 NTP_transf_7