CleftGeneDB-Search

Gene: TENT5C

Basic information

Tag	Content
Uniprot ID	Q5VWP2; A3KMG2; Q8NE25; Q9NXK0;
Entrez ID	54855
Genbank protein ID	AAH36516.3; BAA91010.1; AAI31727.1;
Genbank nucleotide ID	NM_017709.3
Ensembl protein ID	ENSP00000358458
Ensembl nucleotide ID	ENSG00000183508
Gene name	Terminal nucleotidyltransferase 5C
Gene symbol	TENT5C
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death.
Sequence	MAEESSCTRD CMSFSVLNWD QVSRLHEVLT EVVPIHGRGN FPTLEITLKD IVQTVRSRLE 60 EAGIKVHDVR LNGSAAGHVL VKDNGLGCKD LDLIFHVALP TEAEFQLVRD VVLCSLLNFL 120 PEGVNKLKIS PVTLKEAYVQ KLVKVCTDTD RWSLISLSNK NGKNVELKFV DSIRRQFEFS 180 VDSFQIILDS LLFFYDCSNN PISEHFHPTV IGESMYGDFE EAFDHLQNRL IATKNPEEIR 240 GGGLLKYSNL LVRDFRPTDQ EEIKTLERYM CSRFFIDFPD ILEQQRKLET YLQNHFAEEE 300 RSKYDYLMIL RRVVNESTVC LMGHERRQTL NLISLLALRV LAEQNIIPSA TNVTCYYQPA 360 PYVSDGNFSN YYVAHPPVTY SQPYPTWLPC N 391

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	TENT5C	102178682	A0A452DRJ3		Capra hircus	Prediction	More>>
1:1 ortholog	TENT5C	100059755	F7DFD9		Equus caballus	Prediction	More>>
1:1 ortholog	TENT5C	54855	Q5VWP2		Homo sapiens	Prediction	More>>
1:1 ortholog	Tent5c	74645	Q5SSF7	CPO	Mus musculus	Publication	More>>
1:1 ortholog	TENT5C	469434	G2HIG9		Pan troglodytes	Prediction	More>>
1:1 ortholog	TENT5C	100525341	A0A287AN43		Sus scrofa	Prediction	More>>
1:1 ortholog	Tent5c	310721	Q5XIV0		Rattus norvegicus	Prediction	More>>
1:1 ortholog	tent5c		B0V2X8		Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
COSM4404621	p.Ser5Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117622881A>G	NCI-TCGA Cosmic
rs1443775776	p.Ser5Asn	missense variant	-	NC_000001.11:g.117622882G>A	gnomAD
rs1236957064	p.Arg9Ser	missense variant	-	NC_000001.11:g.117622895G>C	TOPMed
COSM3471991	p.Asp10Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117622896G>A	NCI-TCGA Cosmic
rs772416638	p.Cys11Arg	missense variant	-	NC_000001.11:g.117622899T>C	ExAC,TOPMed,gnomAD
rs1324426912	p.Met12Leu	missense variant	-	NC_000001.11:g.117622902A>C	TOPMed
NCI-TCGA novel	p.Met12Val	missense variant	-	NC_000001.11:g.117622902A>G	NCI-TCGA
rs773475817	p.Met12Ile	missense variant	-	NC_000001.11:g.117622904G>T	ExAC,gnomAD
rs34495780	p.Val16Met	missense variant	-	NC_000001.11:g.117622914G>A	ESP,ExAC,TOPMed,gnomAD
RCV000120905	p.Val16Met	missense variant	-	NC_000001.11:g.117622914G>A	ClinVar
rs1376138887	p.Val16Gly	missense variant	-	NC_000001.11:g.117622915T>G	gnomAD
rs776635415	p.Asn18Ile	missense variant	-	NC_000001.11:g.117622921A>T	ExAC,gnomAD
rs776635415	p.Asn18Ser	missense variant	-	NC_000001.11:g.117622921A>G	ExAC,gnomAD
rs912269955	p.Asp20Tyr	missense variant	-	NC_000001.11:g.117622926G>T	TOPMed,gnomAD
rs912269955	p.Asp20Asn	missense variant	-	NC_000001.11:g.117622926G>A	TOPMed,gnomAD
rs1279927757	p.Gln21His	missense variant	-	NC_000001.11:g.117622931G>C	TOPMed
rs1374365686	p.Val28Ile	missense variant	-	NC_000001.11:g.117622950G>A	TOPMed
RCV000120904	p.Thr30Ser	missense variant	-	NC_000001.11:g.117622957C>G	ClinVar
rs758089123	p.Thr30Ala	missense variant	-	NC_000001.11:g.117622956A>G	ExAC,TOPMed,gnomAD
rs758089123	p.Thr30Ser	missense variant	-	NC_000001.11:g.117622956A>T	ExAC,TOPMed,gnomAD
rs587778307	p.Thr30Ser	missense variant	-	NC_000001.11:g.117622957C>G	-
rs1260403191	p.Val32Ile	missense variant	-	NC_000001.11:g.117622962G>A	gnomAD
rs751161016	p.Val33Ile	missense variant	-	NC_000001.11:g.117622965G>A	ExAC,gnomAD
rs749814000	p.Ile35Thr	missense variant	-	NC_000001.11:g.117622972T>C	ExAC,gnomAD
rs1173277102	p.Ile35Val	missense variant	-	NC_000001.11:g.117622971A>G	TOPMed
rs779398843	p.Gly37Arg	missense variant	-	NC_000001.11:g.117622977G>A	ExAC,TOPMed,gnomAD
rs921184290	p.Arg38Ter	stop gained	-	NC_000001.11:g.117622980C>T	TOPMed
rs148397151	p.Arg38Gln	missense variant	-	NC_000001.11:g.117622981G>A	ESP,ExAC,TOPMed,gnomAD
rs921184290	p.Arg38Ter	stop gained	-	NC_000001.11:g.117622980C>T	NCI-TCGA
NCI-TCGA novel	p.Gly39Ala	missense variant	-	NC_000001.11:g.117622984G>C	NCI-TCGA
rs772518025	p.Asn40Lys	missense variant	-	NC_000001.11:g.117622988C>G	ExAC,gnomAD
NCI-TCGA novel	p.Asn40Ser	missense variant	-	NC_000001.11:g.117622987A>G	NCI-TCGA
rs1378831831	p.Phe41Val	missense variant	-	NC_000001.11:g.117622989T>G	TOPMed
COSM3471992	p.Pro42Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117622992C>T	NCI-TCGA Cosmic
rs953053109	p.Leu44Val	missense variant	-	NC_000001.11:g.117622998T>G	gnomAD
rs773602227	p.Glu45Gln	missense variant	-	NC_000001.11:g.117623001G>C	ExAC,gnomAD
rs1230332453	p.Ile46Thr	missense variant	-	NC_000001.11:g.117623005T>C	gnomAD
rs747161845	p.Ile46Val	missense variant	-	NC_000001.11:g.117623004A>G	ExAC,gnomAD
rs1186011113	p.Asp50Asn	missense variant	-	NC_000001.11:g.117623016G>A	TOPMed
rs538766512	p.Val52Ile	missense variant	-	NC_000001.11:g.117623022G>A	1000Genomes,ExAC,gnomAD
rs538766512	p.Val52Ile	missense variant	-	NC_000001.11:g.117623022G>A	NCI-TCGA,NCI-TCGA Cosmic
rs553880208	p.Gln53Pro	missense variant	-	NC_000001.11:g.117623026A>C	1000Genomes,ExAC,TOPMed,gnomAD
rs775316333	p.Thr54Ile	missense variant	-	NC_000001.11:g.117623029C>T	ExAC,gnomAD
rs763834209	p.Val55Ile	missense variant	-	NC_000001.11:g.117623031G>A	ExAC,gnomAD
rs565811357	p.Arg56Leu	missense variant	-	NC_000001.11:g.117623035G>T	1000Genomes,ExAC,TOPMed,gnomAD
rs565811357	p.Arg56His	missense variant	-	NC_000001.11:g.117623035G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs565811357	p.Arg56His	missense variant	-	NC_000001.11:g.117623035G>A	NCI-TCGA,NCI-TCGA Cosmic
rs756798728	p.Arg56Cys	missense variant	-	NC_000001.11:g.117623034C>T	ExAC,gnomAD
rs755549163	p.Ser57Arg	missense variant	-	NC_000001.11:g.117623039T>A	ExAC,gnomAD
rs768091631	p.Arg58Trp	missense variant	-	NC_000001.11:g.117623040C>T	ExAC,TOPMed,gnomAD
rs776281952	p.Arg58Gln	missense variant	-	NC_000001.11:g.117623041G>A	TOPMed,gnomAD
rs1630312	p.His67Gln	missense variant	-	NC_000001.11:g.117623069C>G	UniProt,dbSNP
VAR_060132	p.His67Gln	missense variant	-	NC_000001.11:g.117623069C>G	UniProt
rs1630312	p.His67Gln	missense variant	-	NC_000001.11:g.117623069C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000120902	p.His67Gln	missense variant	-	NC_000001.11:g.117623069C>G	ClinVar
rs758840994	p.His67Arg	missense variant	-	NC_000001.11:g.117623068A>G	ExAC,gnomAD
rs771057074	p.Asp68Asn	missense variant	-	NC_000001.11:g.117623070G>A	ExAC,gnomAD
rs745917069	p.Val69Ile	missense variant	-	NC_000001.11:g.117623073G>A	NCI-TCGA,NCI-TCGA Cosmic
rs745917069	p.Val69Ile	missense variant	-	NC_000001.11:g.117623073G>A	ExAC,TOPMed,gnomAD
rs1432369724	p.Arg70Trp	missense variant	-	NC_000001.11:g.117623076C>T	NCI-TCGA Cosmic
rs1432369724	p.Arg70Trp	missense variant	-	NC_000001.11:g.117623076C>T	TOPMed
rs762807647	p.Asn72Asp	missense variant	-	NC_000001.11:g.117623082A>G	ExAC,gnomAD
rs1355231501	p.Asn72Ser	missense variant	-	NC_000001.11:g.117623083A>G	gnomAD
rs1278971822	p.Ala75Thr	missense variant	-	NC_000001.11:g.117623091G>A	gnomAD
rs1278971822	p.Ala75Thr	missense variant	-	NC_000001.11:g.117623091G>A	NCI-TCGA
rs1211776583	p.Val79Ile	missense variant	-	NC_000001.11:g.117623103G>A	gnomAD
rs1165810632	p.Lys82Arg	missense variant	-	NC_000001.11:g.117623113A>G	TOPMed
rs767046262	p.Leu86Phe	missense variant	-	NC_000001.11:g.117623126G>T	ExAC,gnomAD
rs1385230345	p.Gly87Val	missense variant	-	NC_000001.11:g.117623128G>T	TOPMed
rs765921039	p.Cys88Phe	missense variant	-	NC_000001.11:g.117623131G>T	ExAC,gnomAD
rs139168147	p.Leu93Val	missense variant	-	NC_000001.11:g.117623145C>G	ESP,ExAC,TOPMed,gnomAD
rs1354348705	p.Ile94Thr	missense variant	-	NC_000001.11:g.117623149T>C	gnomAD
rs757552843	p.Phe95Leu	missense variant	-	NC_000001.11:g.117623153C>G	ExAC,gnomAD
rs1371399685	p.Phe95Ser	missense variant	-	NC_000001.11:g.117623152T>C	gnomAD
rs751943358	p.Phe95Leu	missense variant	-	NC_000001.11:g.117623151T>C	ExAC,TOPMed,gnomAD
rs781294756	p.His96Leu	missense variant	-	NC_000001.11:g.117623155A>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.His96MetPheSerTerUnkUnk	frameshift	-	NC_000001.11:g.117623153C>-	NCI-TCGA
rs190981033	p.His96Gln	missense variant	-	NC_000001.11:g.117623156T>G	1000Genomes,ExAC,gnomAD
rs781294756	p.His96Arg	missense variant	-	NC_000001.11:g.117623155A>G	ExAC,TOPMed,gnomAD
rs1293686110	p.Ala98Pro	missense variant	-	NC_000001.11:g.117623160G>C	TOPMed
rs1302106502	p.Leu99Phe	missense variant	-	NC_000001.11:g.117623163C>T	gnomAD
NCI-TCGA novel	p.Pro100Ser	missense variant	-	NC_000001.11:g.117623166C>T	NCI-TCGA
rs893973707	p.Phe105Leu	missense variant	-	NC_000001.11:g.117623181T>C	gnomAD
COSM116444	p.Gln106Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117623185A>T	NCI-TCGA Cosmic
COSM3862349	p.Gln106Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000001.11:g.117623184C>T	NCI-TCGA Cosmic
rs1358461933	p.Leu107Val	missense variant	-	NC_000001.11:g.117623187C>G	TOPMed
rs769764155	p.Val108Ile	missense variant	-	NC_000001.11:g.117623190G>A	ExAC,gnomAD
rs951158173	p.Asp110Asn	missense variant	-	NC_000001.11:g.117623196G>A	TOPMed
NCI-TCGA novel	p.Asp110Tyr	missense variant	-	NC_000001.11:g.117623196G>T	NCI-TCGA
rs1196590539	p.Leu113Pro	missense variant	-	NC_000001.11:g.117623206T>C	gnomAD
NCI-TCGA novel	p.Leu113Met	missense variant	-	NC_000001.11:g.117623205C>A	NCI-TCGA
rs780049033	p.Ser115Cys	missense variant	-	NC_000001.11:g.117623212C>G	ExAC,gnomAD
rs780049033	p.Ser115Phe	missense variant	-	NC_000001.11:g.117623212C>T	NCI-TCGA Cosmic
rs780049033	p.Ser115Phe	missense variant	-	NC_000001.11:g.117623212C>T	ExAC,gnomAD
COSM4990424	p.Leu116Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117623214C>T	NCI-TCGA Cosmic
rs371789381	p.Asn118Asp	missense variant	-	NC_000001.11:g.117623220A>G	ESP,ExAC,TOPMed,gnomAD
rs556415905	p.Asn118Lys	missense variant	-	NC_000001.11:g.117623222C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs556415905	p.Asn118Lys	missense variant	-	NC_000001.11:g.117623222C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs774169628	p.Phe119Leu	missense variant	-	NC_000001.11:g.117623223T>C	ExAC,gnomAD
rs1303373643	p.Phe119Ser	missense variant	-	NC_000001.11:g.117623224T>C	TOPMed
COSM4021140	p.Pro121Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117623229C>T	NCI-TCGA Cosmic
COSM4414269	p.Pro121Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117623229C>G	NCI-TCGA Cosmic
rs1191996445	p.Pro121Leu	missense variant	-	NC_000001.11:g.117623230C>T	gnomAD
rs1419000325	p.Glu122Val	missense variant	-	NC_000001.11:g.117623233A>T	gnomAD
rs1419000325	p.Glu122Gly	missense variant	-	NC_000001.11:g.117623233A>G	gnomAD
rs1476955055	p.Gly123Ser	missense variant	-	NC_000001.11:g.117623235G>A	TOPMed,gnomAD
rs1349639622	p.Gly123Val	missense variant	-	NC_000001.11:g.117623236G>T	TOPMed
rs1476955055	p.Gly123Cys	missense variant	-	NC_000001.11:g.117623235G>T	TOPMed,gnomAD
rs1476955055	p.Gly123Ser	missense variant	-	NC_000001.11:g.117623235G>A	NCI-TCGA
NCI-TCGA novel	p.Asn125Ser	missense variant	-	NC_000001.11:g.117623242A>G	NCI-TCGA
rs761490678	p.Lys128Arg	missense variant	-	NC_000001.11:g.117623251A>G	ExAC,gnomAD
NCI-TCGA novel	p.Ile129Asn	missense variant	-	NC_000001.11:g.117623254T>A	NCI-TCGA
rs774747996	p.Pro131Leu	missense variant	-	NC_000001.11:g.117623260C>T	ExAC,gnomAD
rs1420340818	p.Val132Ile	missense variant	-	NC_000001.11:g.117623262G>A	TOPMed
rs1322105910	p.Thr133Ser	missense variant	-	NC_000001.11:g.117623266C>G	gnomAD
rs1461402036	p.Thr133Ala	missense variant	-	NC_000001.11:g.117623265A>G	gnomAD
rs965004236	p.Ala137Val	missense variant	-	NC_000001.11:g.117623278C>T	TOPMed
rs772744645	p.Ala137Thr	missense variant	-	NC_000001.11:g.117623277G>A	ExAC,gnomAD
rs766046722	p.Val139Met	missense variant	-	NC_000001.11:g.117623283G>A	ExAC,gnomAD
rs376181122	p.Gln140Arg	missense variant	-	NC_000001.11:g.117623287A>G	ESP,ExAC,TOPMed,gnomAD
rs781549053	p.Thr147Met	missense variant	-	NC_000001.11:g.117623308C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Asp148Gly	missense variant	-	NC_000001.11:g.117623311A>G	NCI-TCGA
rs145001981	p.Thr149Ile	missense variant	-	NC_000001.11:g.117623314C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs749332682	p.Arg151Leu	missense variant	-	NC_000001.11:g.117623320G>T	ExAC,TOPMed,gnomAD
rs749332682	p.Arg151His	missense variant	-	NC_000001.11:g.117623320G>A	ExAC,TOPMed,gnomAD
rs780173405	p.Arg151Ser	missense variant	-	NC_000001.11:g.117623319C>A	ExAC,TOPMed,gnomAD
rs780173405	p.Arg151Cys	missense variant	-	NC_000001.11:g.117623319C>T	NCI-TCGA
rs780173405	p.Arg151Cys	missense variant	-	NC_000001.11:g.117623319C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ser158Phe	missense variant	-	NC_000001.11:g.117623341C>T	NCI-TCGA
rs201507664	p.Asn159Tyr	missense variant	-	NC_000001.11:g.117623343A>T	1000Genomes,ExAC,gnomAD
rs1422217522	p.Lys160Asn	missense variant	-	NC_000001.11:g.117623348G>T	TOPMed,gnomAD
rs1359326657	p.Gly162Arg	missense variant	-	NC_000001.11:g.117623352G>A	TOPMed,gnomAD
NCI-TCGA novel	p.Asn164Ile	missense variant	-	NC_000001.11:g.117623359A>T	NCI-TCGA
rs746707589	p.Val165Met	missense variant	-	NC_000001.11:g.117623361G>A	ExAC,gnomAD
rs1170591104	p.Phe169Ser	missense variant	-	NC_000001.11:g.117623374T>C	TOPMed
rs776332343	p.Val170Ala	missense variant	-	NC_000001.11:g.117623377T>C	ExAC,gnomAD
rs1282197258	p.Val170Phe	missense variant	-	NC_000001.11:g.117623376G>T	gnomAD
rs147179158	p.Asp171Asn	missense variant	-	NC_000001.11:g.117623379G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs147179158	p.Asp171Asn	missense variant	-	NC_000001.11:g.117623379G>A	NCI-TCGA
rs762319543	p.Ile173Thr	missense variant	-	NC_000001.11:g.117623386T>C	ExAC,gnomAD
rs767827215	p.Arg174Trp	missense variant	-	NC_000001.11:g.117623388C>T	NCI-TCGA
rs750792861	p.Arg174Gln	missense variant	-	NC_000001.11:g.117623389G>A	NCI-TCGA,NCI-TCGA Cosmic
rs750792861	p.Arg174Gln	missense variant	-	NC_000001.11:g.117623389G>A	ExAC,TOPMed
rs767827215	p.Arg174Trp	missense variant	-	NC_000001.11:g.117623388C>T	ExAC,TOPMed,gnomAD
rs756366617	p.Arg175Cys	missense variant	-	NC_000001.11:g.117623391C>T	ExAC,gnomAD
rs756366617	p.Arg175Cys	missense variant	-	NC_000001.11:g.117623391C>T	NCI-TCGA
rs1185953882	p.Gln176His	missense variant	-	NC_000001.11:g.117623396G>T	gnomAD
rs1431680747	p.Ser180Gly	missense variant	-	NC_000001.11:g.117623406A>G	gnomAD
rs1239549020	p.Val181Ala	missense variant	-	NC_000001.11:g.117623410T>C	gnomAD
rs1379186922	p.Phe184Val	missense variant	-	NC_000001.11:g.117623418T>G	gnomAD
rs1277828975	p.Ile186Val	missense variant	-	NC_000001.11:g.117623424A>G	gnomAD
rs754010269	p.Ile187Asn	missense variant	-	NC_000001.11:g.117623428T>A	ExAC,gnomAD
rs766564274	p.Ile187Phe	missense variant	-	NC_000001.11:g.117623427A>T	ExAC,gnomAD
NCI-TCGA novel	p.Ser190Phe	missense variant	-	NC_000001.11:g.117623437C>T	NCI-TCGA
rs748094673	p.Leu191Phe	missense variant	-	NC_000001.11:g.117623441G>C	ExAC,gnomAD
NCI-TCGA novel	p.Phe194Leu	missense variant	-	NC_000001.11:g.117623450C>G	NCI-TCGA
rs373419973	p.Tyr195Cys	missense variant	-	NC_000001.11:g.117623452A>G	ESP,ExAC,TOPMed,gnomAD
rs746800316	p.Cys197Arg	missense variant	-	NC_000001.11:g.117623457T>C	ExAC,gnomAD
rs770804707	p.Asn199Ser	missense variant	-	NC_000001.11:g.117623464A>G	ExAC,gnomAD
rs776457933	p.Asn200Ser	missense variant	-	NC_000001.11:g.117623467A>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Pro201Ser	missense variant	-	NC_000001.11:g.117623469C>T	NCI-TCGA
NCI-TCGA novel	p.Pro201Leu	missense variant	-	NC_000001.11:g.117623470C>T	NCI-TCGA
rs745444038	p.Pro201Thr	missense variant	-	NC_000001.11:g.117623469C>A	ExAC,TOPMed,gnomAD
rs1310015046	p.Pro208Arg	missense variant	-	NC_000001.11:g.117623491C>G	TOPMed
rs775048736	p.Thr209Ser	missense variant	-	NC_000001.11:g.117623493A>T	ExAC,gnomAD
rs773496649	p.Ile211Thr	missense variant	-	NC_000001.11:g.117623500T>C	ExAC,gnomAD
rs1181723324	p.Ile211Phe	missense variant	-	NC_000001.11:g.117623499A>T	gnomAD
NCI-TCGA novel	p.Gly212Arg	missense variant	-	NC_000001.11:g.117623502G>A	NCI-TCGA
rs1442073130	p.Met215Thr	missense variant	-	NC_000001.11:g.117623512T>C	gnomAD
rs766689047	p.Gly217Arg	missense variant	-	NC_000001.11:g.117623517G>A	ExAC,gnomAD
COSM3471996	p.Asp218Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117623520G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Glu221ValPheSerTerUnkUnk	frameshift	-	NC_000001.11:g.117623529_117623530insTTGGGGACCACTGGTGTGGC	NCI-TCGA
rs754073638	p.Ala222Asp	missense variant	-	NC_000001.11:g.117623533C>A	ExAC,gnomAD
NCI-TCGA novel	p.Asp224Asn	missense variant	-	NC_000001.11:g.117623538G>A	NCI-TCGA
rs377384965	p.Asp224Glu	missense variant	-	NC_000001.11:g.117623540C>A	ESP,ExAC,TOPMed,gnomAD
rs1331321666	p.Gln227Arg	missense variant	-	NC_000001.11:g.117623548A>G	TOPMed
rs371434677	p.Ala232Thr	missense variant	-	NC_000001.11:g.117623562G>A	NCI-TCGA
rs752792421	p.Ala232Val	missense variant	-	NC_000001.11:g.117623563C>T	ExAC,TOPMed,gnomAD
rs371434677	p.Ala232Ser	missense variant	-	NC_000001.11:g.117623562G>T	ESP,gnomAD
rs371434677	p.Ala232Thr	missense variant	-	NC_000001.11:g.117623562G>A	ESP,gnomAD
rs1337416217	p.Lys234Asn	missense variant	-	NC_000001.11:g.117623570G>C	TOPMed
rs1310140275	p.Asn235Ser	missense variant	-	NC_000001.11:g.117623572A>G	gnomAD
rs1231378622	p.Pro236Thr	missense variant	-	NC_000001.11:g.117623574C>A	gnomAD
rs1198478524	p.Gly242Glu	missense variant	-	NC_000001.11:g.117623593G>A	gnomAD
NCI-TCGA novel	p.Gly242Arg	missense variant	-	NC_000001.11:g.117623592G>A	NCI-TCGA
rs757126681	p.Leu244Phe	missense variant	-	NC_000001.11:g.117623598C>T	ExAC,gnomAD
COSM2156513	p.Leu244Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117623598C>G	NCI-TCGA Cosmic
rs745570371	p.Asn249Ser	missense variant	-	NC_000001.11:g.117623614A>G	ExAC,gnomAD
rs769480797	p.Leu251Phe	missense variant	-	NC_000001.11:g.117623619C>T	ExAC,gnomAD
rs915278770	p.Val252Leu	missense variant	-	NC_000001.11:g.117623622G>C	TOPMed
rs779467652	p.Arg253Gln	missense variant	-	NC_000001.11:g.117623626G>A	NCI-TCGA,NCI-TCGA Cosmic
rs779467652	p.Arg253Gln	missense variant	-	NC_000001.11:g.117623626G>A	ExAC,TOPMed,gnomAD
rs1379420313	p.Arg253Trp	missense variant	-	NC_000001.11:g.117623625C>T	TOPMed
rs1462556539	p.Asp254Asn	missense variant	-	NC_000001.11:g.117623628G>A	TOPMed
rs587778306	p.Thr258Ile	missense variant	-	NC_000001.11:g.117623641C>T	gnomAD
RCV000120903	p.Thr258Ile	missense variant	-	NC_000001.11:g.117623641C>T	ClinVar
RCV000120906	p.Asp259Tyr	missense variant	-	NC_000001.11:g.117623643G>T	ClinVar
rs587778308	p.Asp259Tyr	missense variant	-	NC_000001.11:g.117623643G>T	-
COSM3788499	p.Asp259His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117623643G>C	NCI-TCGA Cosmic
COSM1688388	p.Glu261Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117623649G>A	NCI-TCGA Cosmic
COSM894532	p.Glu262Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117623654A>C	NCI-TCGA Cosmic
NCI-TCGA novel	p.Glu262Ter	stop gained	-	NC_000001.11:g.117623652G>T	NCI-TCGA
NCI-TCGA novel	p.Ile263Leu	missense variant	-	NC_000001.11:g.117623655A>C	NCI-TCGA
NCI-TCGA novel	p.Ile263Met	missense variant	-	NC_000001.11:g.117623657C>G	NCI-TCGA
NCI-TCGA novel	p.Lys264Arg	missense variant	-	NC_000001.11:g.117623659A>G	NCI-TCGA
rs1487005772	p.Glu267Gln	missense variant	-	NC_000001.11:g.117623667G>C	gnomAD
rs761103312	p.Arg268Cys	missense variant	-	NC_000001.11:g.117623670C>T	ExAC,TOPMed,gnomAD
rs754072349	p.Arg268His	missense variant	-	NC_000001.11:g.117623671G>A	ExAC,TOPMed,gnomAD
rs1239289962	p.Met270Val	missense variant	-	NC_000001.11:g.117623676A>G	TOPMed
COSM894533	p.Phe274Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117623688T>C	NCI-TCGA Cosmic
NCI-TCGA novel	p.Phe275Tyr	missense variant	-	NC_000001.11:g.117623692T>A	NCI-TCGA
NCI-TCGA novel	p.Ile276ProPheSerTerUnkUnk	frameshift	-	NC_000001.11:g.117623693_117623694insCCGTTCTTGTTGG	NCI-TCGA
rs778618300	p.Pro279Leu	missense variant	-	NC_000001.11:g.117623704C>T	ExAC,TOPMed,gnomAD
RCV000120901	p.Ile281Val	missense variant	-	NC_000001.11:g.117623709A>G	ClinVar
rs77871185	p.Ile281Val	missense variant	-	NC_000001.11:g.117623709A>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs764017740	p.Leu282Val	missense variant	-	NC_000001.11:g.117623712C>G	ExAC,gnomAD
rs1219813462	p.Arg286Lys	missense variant	-	NC_000001.11:g.117623725G>A	gnomAD
rs758092069	p.Leu288Val	missense variant	-	NC_000001.11:g.117623730T>G	TOPMed,gnomAD
rs764728855	p.Tyr291Ter	stop gained	-	NC_000001.11:g.117623740dup	ExAC,gnomAD
rs149654076	p.Ala297Thr	missense variant	-	NC_000001.11:g.117623757G>A	NCI-TCGA,NCI-TCGA Cosmic
rs149654076	p.Ala297Pro	missense variant	-	NC_000001.11:g.117623757G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs149654076	p.Ala297Thr	missense variant	-	NC_000001.11:g.117623757G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000120907	p.Ala297Thr	missense variant	-	NC_000001.11:g.117623757G>A	ClinVar
rs145471785	p.Glu299Lys	missense variant	-	NC_000001.11:g.117623763G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000120908	p.Glu299Lys	missense variant	-	NC_000001.11:g.117623763G>A	ClinVar
rs768215715	p.Ser302Asn	missense variant	-	NC_000001.11:g.117623773G>A	ExAC,TOPMed,gnomAD
rs538158859	p.Ser302Gly	missense variant	-	NC_000001.11:g.117623772A>G	1000Genomes,ExAC,gnomAD
rs538158859	p.Ser302Arg	missense variant	-	NC_000001.11:g.117623772A>C	1000Genomes,ExAC,gnomAD
rs747582052	p.Lys303Gln	missense variant	-	NC_000001.11:g.117623775A>C	ExAC,gnomAD
rs1391512260	p.Asp305Asn	missense variant	-	NC_000001.11:g.117623781G>A	TOPMed,gnomAD
rs1312455607	p.Met308Ile	missense variant	-	NC_000001.11:g.117623792G>C	gnomAD
rs770016455	p.Met308Thr	missense variant	-	NC_000001.11:g.117623791T>C	ExAC,gnomAD
rs150740852	p.Met308Leu	missense variant	-	NC_000001.11:g.117623790A>C	ESP,ExAC,TOPMed,gnomAD
rs150740852	p.Met308Val	missense variant	-	NC_000001.11:g.117623790A>G	ESP,ExAC,TOPMed,gnomAD
rs372516345	p.Ile309Thr	missense variant	-	NC_000001.11:g.117623794T>C	ESP,TOPMed
rs775789017	p.Arg311Cys	missense variant	-	NC_000001.11:g.117623799C>T	NCI-TCGA,NCI-TCGA Cosmic
rs775789017	p.Arg311Cys	missense variant	-	NC_000001.11:g.117623799C>T	ExAC,TOPMed,gnomAD
COSM3471998	p.Arg312Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117623803G>T	NCI-TCGA Cosmic
rs764287568	p.Glu316Lys	missense variant	-	NC_000001.11:g.117623814G>A	ExAC,TOPMed,gnomAD
rs764287568	p.Glu316Lys	missense variant	-	NC_000001.11:g.117623814G>A	NCI-TCGA
rs1215452754	p.Thr318Ala	missense variant	-	NC_000001.11:g.117623820A>G	gnomAD
NCI-TCGA novel	p.Val319Leu	missense variant	-	NC_000001.11:g.117623823G>T	NCI-TCGA
rs767537718	p.Val319Met	missense variant	-	NC_000001.11:g.117623823G>A	ExAC,TOPMed,gnomAD
rs1186956228	p.Gly323Glu	missense variant	-	NC_000001.11:g.117623836G>A	gnomAD
rs1186956228	p.Gly323Glu	missense variant	-	NC_000001.11:g.117623836G>A	NCI-TCGA Cosmic
rs755966473	p.Arg326Leu	missense variant	-	NC_000001.11:g.117623845G>T	ExAC,gnomAD
rs755966473	p.Arg326His	missense variant	-	NC_000001.11:g.117623845G>A	ExAC,gnomAD
rs750335875	p.Arg326Cys	missense variant	-	NC_000001.11:g.117623844C>T	ExAC,gnomAD
rs1281807855	p.Ile333Phe	missense variant	-	NC_000001.11:g.117623865A>T	TOPMed,gnomAD
COSM3472000	p.Ser334Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117623869C>T	NCI-TCGA Cosmic
rs1383000604	p.Ser334Cys	missense variant	-	NC_000001.11:g.117623869C>G	TOPMed
rs753542382	p.Arg339His	missense variant	-	NC_000001.11:g.117623884G>A	ExAC,TOPMed,gnomAD
rs376774297	p.Ala342Val	missense variant	-	NC_000001.11:g.117623893C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Asn345LysPheSerTerUnkUnk	frameshift	-	NC_000001.11:g.117623903C>-	NCI-TCGA
rs930666933	p.Ile346Val	missense variant	-	NC_000001.11:g.117623904A>G	TOPMed,gnomAD
rs1238866114	p.Ile347Leu	missense variant	-	NC_000001.11:g.117623907A>C	gnomAD
rs747636778	p.Ser349Cys	missense variant	-	NC_000001.11:g.117623913A>T	ExAC,gnomAD
rs1355458797	p.Ser349Asn	missense variant	-	NC_000001.11:g.117623914G>A	gnomAD
rs757856198	p.Asn352Ser	missense variant	-	NC_000001.11:g.117623923A>G	ExAC,TOPMed,gnomAD
rs74114325	p.Val353Ile	missense variant	-	NC_000001.11:g.117623925G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs557599465	p.Pro359Leu	missense variant	-	NC_000001.11:g.117623944C>T	TOPMed,gnomAD
rs557599465	p.Pro359Leu	missense variant	-	NC_000001.11:g.117623944C>T	NCI-TCGA
rs1354785362	p.Pro361Leu	missense variant	-	NC_000001.11:g.117623950C>T	TOPMed
COSM3862351	p.Pro361Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.117623949C>T	NCI-TCGA Cosmic
rs773285739	p.Val363Ile	missense variant	-	NC_000001.11:g.117623955G>A	ExAC,TOPMed,gnomAD
rs773285739	p.Val363Ile	missense variant	-	NC_000001.11:g.117623955G>A	NCI-TCGA,NCI-TCGA Cosmic
rs773285739	p.Val363Phe	missense variant	-	NC_000001.11:g.117623955G>T	ExAC,TOPMed,gnomAD
rs760471278	p.Asp365Ala	missense variant	-	NC_000001.11:g.117623962A>C	ExAC
NCI-TCGA novel	p.Asp365Asn	missense variant	-	NC_000001.11:g.117623961G>A	NCI-TCGA
rs1256168715	p.Asn367Thr	missense variant	-	NC_000001.11:g.117623968A>C	TOPMed,gnomAD
rs1400295239	p.Ser369Asn	missense variant	-	NC_000001.11:g.117623974G>A	gnomAD
rs753546205	p.Asn370Lys	missense variant	-	NC_000001.11:g.117623978C>G	ExAC,gnomAD
rs754709388	p.Tyr372His	missense variant	-	NC_000001.11:g.117623982T>C	ExAC,gnomAD
rs752308622	p.Val373Ile	missense variant	-	NC_000001.11:g.117623985G>A	ExAC,gnomAD
rs1345951307	p.Ala374Val	missense variant	-	NC_000001.11:g.117623989C>T	TOPMed
NCI-TCGA novel	p.Pro377Ser	missense variant	-	NC_000001.11:g.117623997C>T	NCI-TCGA
rs1212041385	p.Val378Ile	missense variant	-	NC_000001.11:g.117624000G>A	gnomAD
rs746449090	p.Tyr380Asp	missense variant	-	NC_000001.11:g.117624006T>G	ExAC,TOPMed,gnomAD
rs746449090	p.Tyr380His	missense variant	-	NC_000001.11:g.117624006T>C	ExAC,TOPMed,gnomAD
rs1185278454	p.Ser381Arg	missense variant	-	NC_000001.11:g.117624009A>C	gnomAD
rs780504872	p.Gln382His	missense variant	-	NC_000001.11:g.117624014G>C	ExAC,gnomAD
rs749590706	p.Tyr384Cys	missense variant	-	NC_000001.11:g.117624019A>G	ExAC,TOPMed,gnomAD
rs769091230	p.Pro385His	missense variant	-	NC_000001.11:g.117624022C>A	ExAC
rs774743199	p.Trp387Cys	missense variant	-	NC_000001.11:g.117624029G>C	ExAC,TOPMed,gnomAD
rs774743199	p.Trp387Ter	stop gained	-	NC_000001.11:g.117624029G>A	ExAC,TOPMed,gnomAD
rs774743199	p.Trp387Cys	missense variant	-	NC_000001.11:g.117624029G>T	ExAC,TOPMed,gnomAD
rs774743199	p.Trp387Ter	stop gained	-	NC_000001.11:g.117624029G>A	NCI-TCGA
rs1423398747	p.Pro389Arg	missense variant	-	NC_000001.11:g.117624034C>G	TOPMed,gnomAD
rs1423398747	p.Pro389Leu	missense variant	-	NC_000001.11:g.117624034C>T	TOPMed,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0026764	Multiple Myeloma	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0003723	RNA binding	IEA
GO:0005515	protein binding	IPI
GO:1990817	RNA adenylyltransferase activity	IDA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001701	in utero embryonic development	IEA
GO:0016032	viral process	IEA
GO:0048255	mRNA stabilization	IDA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence

Drugs and compounds information

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	1,2,5,6-dibenzanthracene results in decreased expression of TENT5C mRNA	26377693
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of TENT5C mRNA	24810058
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TENT5C mRNA	23196670
C549543	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in increased expression of TENT5C mRNA	25716159
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in decreased expression of TENT5C mRNA	30723492
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to TENT5C protein	26598702
C032642	4-aminophenylarsenoxide	Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TENT5C protein]	26598702
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of TENT5C mRNA	20382639
D000082	Acetaminophen	Acetaminophen results in increased expression of TENT5C mRNA	21420995
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of TENT5C protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of TENT5C mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TENT5C mRNA	22100608
D000395	Air Pollutants, Occupational	Air Pollutants, Occupational results in increased expression of TENT5C mRNA	23195993
D000447	Aldehydes	Aldehydes results in increased expression of TENT5C mRNA	25014914
D000077237	Arsenic Trioxide	Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TENT5C protein]	26598702
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of TENT5C mRNA	15725085
C015001	arsenite	arsenite affects the expression of TENT5C mRNA	22959463
C049935	avobenzone	avobenzone results in increased expression of TENT5C mRNA	31016361
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TENT5C mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TENT5C mRNA	21569818
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TENT5C mRNA	20127859
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of TENT5C mRNA	26377693
C006780	bisphenol A	bisphenol A affects the expression of TENT5C mRNA	21786754
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of TENT5C mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of TENT5C mRNA	25181051; 30816183;
C018475	butyraldehyde	butyraldehyde results in increased expression of TENT5C mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of TENT5C mRNA	25993096
D002220	Carbamazepine	Carbamazepine affects the expression of TENT5C mRNA	25979313
D007631	Chlordecone	Chlordecone results in increased expression of TENT5C mRNA	29458080
D002945	Cisplatin	Cisplatin results in decreased expression of TENT5C mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased expression of TENT5C mRNA	27392435
D002994	Clofibrate	Clofibrate results in decreased expression of TENT5C mRNA	23811191
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of TENT5C mRNA	24690739
D003300	Copper	Copper results in increased expression of TENT5C mRNA	30556269
D019327	Copper Sulfate	Copper Sulfate results in increased expression of TENT5C mRNA	19549813
D003375	Coumestrol	[Coumestrol co-treated with Resveratrol] results in increased expression of TENT5C mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of TENT5C mRNA	19167446
D003471	Cuprizone	Cuprizone results in increased expression of TENT5C mRNA	26577399; 27523638;
D016572	Cyclosporine	Cyclosporine results in decreased expression of TENT5C mRNA	20106945
D003561	Cytarabine	Cytarabine results in decreased expression of TENT5C mRNA	21198554
D003703	Demecolcine	Demecolcine results in decreased expression of TENT5C mRNA	23649840
D003976	Diazinon	Diazinon results in increased methylation of TENT5C gene	22964155
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of TENT5C mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of TENT5C mRNA	28962523
D004026	Dieldrin	Dieldrin results in increased expression of TENT5C mRNA	23041725
D004041	Dietary Fats	Dietary Fats results in decreased expression of TENT5C mRNA	25016146
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TENT5C mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of TENT5C mRNA	24535843
D004221	Disulfiram	Disulfiram results in decreased expression of TENT5C mRNA	20530235
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of TENT5C mRNA	24690739
C516138	dorsomorphin	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
D004317	Doxorubicin	Doxorubicin results in increased expression of TENT5C mRNA	30031762
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of TENT5C mRNA	26159488
D000069347	Erlotinib Hydrochloride	Erlotinib Hydrochloride results in decreased expression of TENT5C mRNA	27720938
D004958	Estradiol	[Estradiol co-treated with TGFB1 protein] results in decreased expression of TENT5C mRNA	30165855
D004958	Estradiol	Estradiol results in increased expression of TENT5C mRNA	21795739
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of TENT5C mRNA	28189721
D017313	Fenretinide	Fenretinide results in decreased expression of TENT5C mRNA	28973697
D005557	Formaldehyde	Formaldehyde results in decreased expression of TENT5C mRNA	23649840
D005557	Formaldehyde	Formaldehyde results in increased expression of TENT5C mRNA	20655997
C000593030	GSK-J4	GSK-J4 results in increased expression of TENT5C mRNA	29301935
D006220	Haloperidol	Haloperidol results in increased expression of TENT5C mRNA	29458080
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of TENT5C mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of TENT5C mRNA	18951874
D007213	Indomethacin	Indomethacin results in increased expression of TENT5C mRNA	28201806
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TENT5C mRNA	25613284
D015474	Isotretinoin	Isotretinoin results in decreased expression of TENT5C mRNA	20436886
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of TENT5C mRNA	23086925
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of TENT5C mRNA	22904298; 24796395; 25307878; 26752646; 27432991;
C042720	mercuric bromide	mercuric bromide results in increased expression of TENT5C mRNA	26272509
C042720	mercuric bromide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of TENT5C mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of TENT5C mRNA	26011545
C028577	monobutyl phthalate	monobutyl phthalate results in decreased expression of TENT5C mRNA	29162477
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of TENT5C mRNA	25554681
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of TENT5C mRNA	25554681
D009532	Nickel	Nickel results in increased expression of TENT5C mRNA	23195993
D018817	N-Methyl-3,4-methylenedioxyamphetamine	N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TENT5C mRNA	20188158
D010100	Oxygen	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of TENT5C mRNA	30529165
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of TENT5C mRNA	24642059
C046012	pentanal	pentanal results in increased expression of TENT5C mRNA	26079696
D026023	Permethrin	Permethrin results in decreased expression of TENT5C mRNA	30629241
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TENT5C mRNA	24535843
D010634	Phenobarbital	Phenobarbital affects the expression of TENT5C mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of TENT5C mRNA	23091169
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of TENT5C mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of TENT5C mRNA	23811191
D010938	Plant Oils	Plant Oils results in increased expression of TENT5C mRNA	23370395
C005556	propionaldehyde	propionaldehyde results in increased expression of TENT5C mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of TENT5C mRNA	24780913
D011794	Quercetin	Quercetin results in increased expression of TENT5C mRNA	21632981
D000077185	Resveratrol	[Coumestrol co-treated with Resveratrol] results in increased expression of TENT5C mRNA	19167446
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of TENT5C mRNA	19073995
C017947	sodium arsenite	sodium arsenite results in decreased expression of TENT5C mRNA	24516582
C075117	squalestatin 1	squalestatin 1 results in decreased expression of TENT5C mRNA	27225895
D000077210	Sunitinib	Sunitinib results in increased expression of TENT5C mRNA	31533062
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of TENT5C mRNA	26496021
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of TENT5C mRNA	26159488
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TENT5C mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TENT5C mRNA	20106945
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TENT5C mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TENT5C mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TENT5C mRNA	25613284
D013893	Thiram	Thiram results in decreased expression of TENT5C mRNA	20530235
C009495	titanium dioxide	titanium dioxide results in increased expression of TENT5C mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of TENT5C mRNA	28065790
D014212	Tretinoin	Tretinoin results in increased expression of TENT5C mRNA	20530235
C012589	trichostatin A	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
C012589	trichostatin A	trichostatin A affects the expression of TENT5C mRNA	28542535
C012589	trichostatin A	trichostatin A results in increased expression of TENT5C mRNA	24935251; 26272509;
D014260	Triclosan	Triclosan results in increased expression of TENT5C mRNA	30510588
D014520	Urethane	Urethane results in increased expression of TENT5C mRNA	28818685
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of TENT5C mRNA	23179753; 24383497; 26272509; 27188386; 28001369;
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of TENT5C gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of TENT5C mRNA	23034163
D014750	Vincristine	Vincristine results in decreased expression of TENT5C mRNA	23649840
D000077337	Vorinostat	[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENT5C mRNA	27188386

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0963	Cytoplasm
KW-0945	Host-virus interaction
KW-0548	Nucleotidyltransferase
KW-0539	Nucleus
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0694	RNA-binding
KW-0808	Transferase

Interpro

InterPro ID	InterPro Term
IPR012937	TET5

PROSITE

PROSITE ID	PROSITE Term

Pfam

Pfam ID	Pfam Term
PF07984	NTP_transf_7