Gene: Tent5c

Basic information

Tag Content
Uniprot ID Q5XIV0
Entrez ID 310721
Genbank protein ID AAH83570.1
Genbank nucleotide ID XM_006233038.3; NM_001014041.1;
Ensembl protein ID ENSRNOP00000020401
Ensembl nucleotide ID ENSRNOG00000015222
Gene name Terminal nucleotidyltransferase 5C
Gene symbol Tent5c
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death.
Sequence
MADEGSSTKD SESFSVLNWD QVSRLHEVLT EVVPIHGRGN FPTLEITLKD IVQTVRSRLE 60
EAGIKVQDVR LNGSAAGHVL VKDNGLGCKD LDLIFHVALP TEAEFQLVRD VVLCSLLNFL 120
PEGVNKLKIS PVTLKEAYVQ KLVKVCTDTD RWSLISLSNK NGRNVELKFV DSIRRQFEFS 180
VDSFQIILDS LLFFYDCSSN PVSEHFHPTV VGESMYGDFE EAFDHLQNRL IATKNPEEIR 240
GGGLLKYSNL LVRDFRPADQ EEIKTLERYM CSRFFIDFPD ILEQQRKLET YLQNHFADEE 300
RSKYDYLMIL RRVVNESTVC LMGHERRQTL NLISLLALRV LAEQNIIPSA TNVTCYYQPA 360
PYVSDGNFNN YYIAHPPVTY SQPYPTWLPC N 391

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTENT5C102178682A0A452DRJ3Capra hircusPredictionMore>>
1:1 orthologTENT5C100059755F7DFD9Equus caballusPredictionMore>>
1:1 orthologTENT5C54855Q5VWP2Homo sapiensPredictionMore>>
1:1 orthologTent5c74645Q5SSF7CPOMus musculusPublicationMore>>
1:1 orthologTENT5C469434G2HIG9Pan troglodytesPredictionMore>>
1:1 orthologTENT5C100525341A0A287AN43Sus scrofaPredictionMore>>
1:1 orthologTent5c310721Q5XIV0Rattus norvegicusPredictionMore>>
1:1 orthologtent5cB0V2X8Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0005634 nucleus
GO:1990817 RNA adenylyltransferase activity
GO:0003723 RNA binding
GO:0001701 in utero embryonic development
GO:0048255 mRNA stabilization

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0963 Cytoplasm
KW-0548 Nucleotidyltransferase
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0694 RNA-binding
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR012937 TET5

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF07984 NTP_transf_7