Gene: Glg1

Basic information

Tag Content
Uniprot ID Q61543; Q9QZ40;
Entrez ID 20340
Genbank protein ID CAA58855.1; AAH21306.1; CAA73066.1;
Genbank nucleotide ID NM_009149.2
Ensembl protein ID ENSMUSP00000131355
Ensembl nucleotide ID ENSMUSG00000003316
Gene name Golgi apparatus protein 1
Gene symbol Glg1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 20023171
Functional description Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
Sequence
MAVCGRVRGM FRLSAALPLL LLAAAGAQNG HGQGQGPGTN FGPFPGQGGG GSPAGQQPPQ 60
QPQLSQQQQQ PPPQQQQQQQ QQSLFAAGGL PARRGGAGPG GTGGGWKLAE EESCREDVTR 120
VCPKHTWSNN LAVLECLQDV REPENEISSD CNHLLWNYKL NLTTDPKFES VAREVCKSTI 180
SEIKECAEEP VGKGYMVSCL VDHRGNITEY QCHQYITKMT AIIFSDYRLI CGFMDDCKND 240
INLLKCGSIR LGEKDAHSQG EVVSCLEKGL VKEAEEKEPK IQVSELCKKA ILRVAELSSD 300
DFHLDRHLYF ACRDDRERFC ENTQAGEGRV YKCLFNHKFE ESMSEKCREA LTTRQKLIAQ 360
DYKVSYSLAK SCKSDLKKYR CNVENLPRSR EARLSYLLMC LESAVHRGRQ VSSECQGEML 420
DYRRMLMEDF SLSPEIILSC RGEIEHHCSG LHRKGRTLHC LMKVVRGEKG NLGMNCQQAL 480
QTLIQETDPG ADYRIDRALN EACESVIQTA CKHIRSGDPM ILSCLMEHLY TEKMVEDCEH 540
RLLELQYFIS RDWKLDPVLY RKCQGDASRL CHTHGWNETS ELMPPGAVFS CLYRHAYRTE 600
EQGRRLSREC RAEVQRILHQ RAMDVKLDPA LQDKCLIDLG KWCSEKTETG QELECLQDHL 660
DDLAVECRDI VGNLTELESE DIQIEALLMR ACEPIIQNFC HDVADNQIDS GDLMECLIQN 720
KHQKDMNEKC AIGVTHFQLV QMKDFRFSYK FKMACKEDVL KLCPNIKKKV DVVICLSTTV 780
RNDTLQEAKE HRVSLKCRKQ LRVEELEMTE DIRLEPDLYE ACKSDIKNYC STVQYGNAQI 840
IECLKENKKQ LSTRCHQKVF KLQETEMMDP ELDYTLMRVC KQMIKRFCPE ADSKTMLQCL 900
KQNKNSELMD PKCKQMITKR QITQNTDYRL NPVLRKACKA DIPKFCHGIL TKAKDDSELE 960
GQVISCLKLR YADQRLSSDC EDQIRIIIQE SALDYRLDPQ LQLHCSDEIA NLCAEEAAAQ 1020
EQTGQVEECL KVNLLKIKTE LCKKEVLNML KESKADIFVD PVLHTACALD IKHHCAAITP 1080
GRGRQMSCLM EALEDKRVRL QPECKKRLND RIEMWSYAAK VAPADGFSDL AMQVMTSPSK 1140
NYILSVISGS ICILFLIGLM CGRITKRVTR ELKDR 1175

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologGLG1479654F6V9R9Canis lupus familiarisPredictionMore>>
1:1 orthologGLG1A0A452E1L5Capra hircusPredictionMore>>
1:1 orthologGLG1F6Z3Z4Equus caballusPredictionMore>>
1:1 orthologGLG12734Q92896Homo sapiensPredictionMore>>
1:1 orthologGlg120340Q61543CPOMus musculusPublicationMore>>
1:1 orthologGLG1A0A2I3TER7Pan troglodytesPredictionMore>>
1:1 orthologGLG1G1SJQ2Oryctolagus cuniculusPredictionMore>>
1:1 orthologGlg1G3V8G5Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0017134 fibroblast growth factor bindingISO
GO:0017134 fibroblast growth factor bindingIBA

GO:Biological Process

GO ID GO Term Evidence
GO:0010955 negative regulation of protein processingIGI
GO:0010955 negative regulation of protein processingIMP
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathwayIMP
GO:0032330 regulation of chondrocyte differentiationIMP
GO:0060349 bone morphogenesisIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0000139 Golgi membraneIBA
GO:0000139 Golgi membraneIDA
GO:0005794 Golgi apparatusISO
GO:0005794 Golgi apparatusIDA
GO:0005797 Golgi medial cisternaISO
GO:0005856 cytoskeletonIEA
GO:0005886 plasma membraneIEA
GO:0016021 integral component of membraneIEA
GO:0030054 cell junctionIEA
GO:0031012 extracellular matrixIDA
GO:0043231 intracellular membrane-bounded organelleISO
GO:0150051 postsynaptic Golgi apparatusIEA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-109582 HemostasisIEA
R-MMU-202733 Cell surface interactions at the vascular wallIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0965 Cell junction
KW-1003 Cell membrane
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0903 Direct protein sequencing
KW-0325 Glycoprotein
KW-0333 Golgi apparatus
KW-0472 Membrane
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0677 Repeat
KW-0730 Sialic acid
KW-0732 Signal
KW-0770 Synapse
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR001893 Cys-rich_GLG1_repeat
IPR017873 Cys-rich_GLG1_repeat_euk
IPR039728 GLG1

PROSITE

PROSITE ID PROSITE Term
PS51289 GLG1_C_RICH

Pfam

Pfam ID Pfam Term
PF00839 Cys_rich_FGFR

Protein-protein interaction

Protein-miRNA interaction