| Tag | Content |
|---|---|
| Uniprot ID | Q61647 |
| Entrez ID | 15116 |
| Genbank protein ID | BAA11654.1 |
| Genbank nucleotide ID | NM_008215.2 |
| Ensembl protein ID | ENSMUSP00000003762 |
| Ensembl nucleotide ID | ENSMUSG00000003665 |
| Gene name | Hyaluronan synthase 1 |
| Gene symbol | Has1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 31526805; 31509714; |
| Functional description | Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate. |
| Sequence | MRQDMPKPSE AARCCSGLAR RALTIIFALL ILGLMTWAYA AGVPLASDRY GLLAFGLYGA 60 FLSAHLVAQS LFAYLEHRRV AAAARRSLAK GPLDAATARS VALTISAYQE DPAYLRQCLT 120 SARALLYPHT RLRVLMVVDG NRAEDLYMVD MFREVFADED PATYVWDGNY HQPWEPAEAT 180 GAVGEGAYRE VEAEDPGRLA VEALVRTRRC VCVAQRWGGK REVMYTAFKA LGDSVDYVQV 240 CDSDTRLDPM ALLELVRVLD EDPRVGAVGG DVRILNPLDS WVSFLSSLRY WVAFNVERAC 300 QSYFHCVSCI SGPLGLYRNN LLQQFLEAWY NQKFLGTHCT FGDDRHLTNR MLSMGYATKY 360 TSRSRCYSET PSSFLRWLSQ QTRWSKSYFR EWLYNALWWH RHHAWMTYEA VVSGLFPFFV 420 AATVLRLFYA GRPWALLWVL LCVQGVALAK AAFAAWLRGC VRMVLLSLYA PLYMCGLLPA 480 KFLALVTMNQ SGWGTSGRKK LAANYVPVLP LALWALLLLG GLARSVAQEA RADWSGPSRA 540 AEAYHLAAGA GAYVAYWVVM LTIYWVGVRR LCRRRSGGYR VQV 583 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HAS1 | A0A452FT40 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | HAS1 | M0R2V0 | Homo sapiens | Prediction | More>> | |||
| 1:1 ortholog | Has1 | 15116 | Q61647 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | HAS1 | 468978 | A0A2I3TFP5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Has1 | 282821 | Q8CH93 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | has1 | 403130 | X1WCR3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0042802 | identical protein binding | ISO |
| GO:0050501 | hyaluronan synthase activity | IDA |
| GO:0050501 | hyaluronan synthase activity | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0010764 | negative regulation of fibroblast migration | ISO |
| GO:0030213 | hyaluronan biosynthetic process | IEA |
| GO:0030213 | hyaluronan biosynthetic process | IDA |
| GO:0030213 | hyaluronan biosynthetic process | IBA |
| GO:0036120 | cellular response to platelet-derived growth factor stimulus | ISO |
| GO:0044849 | estrous cycle | IEA |
| GO:0045226 | extracellular polysaccharide biosynthetic process | IDA |
| GO:0045226 | extracellular polysaccharide biosynthetic process | IBA |
| GO:0085029 | extracellular matrix assembly | IDA |
| GO:0085029 | extracellular matrix assembly | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005737 | cytoplasm | IDA |
| GO:0005887 | integral component of plasma membrane | IBA |
| GO:0016020 | membrane | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-1630316 | Glycosaminoglycan metabolism | IEA |
| R-MMU-2142845 | Hyaluronan metabolism | IEA |
| R-MMU-2142850 | Hyaluronan biosynthesis and export | IEA |
| R-MMU-71387 | Metabolism of carbohydrates | IEA |