| Tag | Content |
|---|---|
| Uniprot ID | Q6TNS2; Q6NYY5; Q7ZW90; |
| Entrez ID | 336470 |
| Genbank protein ID | AAH49528.2; AAH66416.2; AAQ91257.1; |
| Genbank nucleotide ID | NM_200945.2 |
| Ensembl protein ID | ENSDARP00000065337 |
| Ensembl nucleotide ID | ENSDARG00000044488 |
| Gene name | p21-activated protein kinase-interacting protein 1-like |
| Gene symbol | pak1ip1 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. |
| Sequence | MSECFTVMGD HIELVAGCYE QIVFGYRVCP ADEEWTIEPT FTHHAHTASL NAVSSSNQFI 60 ATGSKDETIQ LYDMCKKTEH GALLHHDGTI SCLEFYGTSH LLSGGQDGLI CVWSTKKWEC 120 LKTIRAHKGQ VTSLSVHPSG KLALSVGTDK TLRTWNLIEG RSAFIKNIKQ NAEIVLWSPD 180 GDKYAVVVND KVDIYTLDSA TIIGTIAFTK RISCLKFLKN SLLAVGGDDE SVRIYDVTSQ 240 KCVCEFKAHE NRVKAIESFM KDDFCVLVTA SNDGFIKLWK LNLESIESPT LLGQLNTTAR 300 LTCLCVWMPG ETKETAEQPA QATTSEDVLD PLVPVRSKRV RILGEEVIME DEKGSKTQGK 360 KKKRQKVQ 368 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PAK1IP1 | 102178321 | A0A452FB78 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PAK1IP1 | 55003 | Q9NWT1 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pak1ip1 | 68083 | Q9DCE5 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PAK1IP1 | 463143 | H2QSA5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PAK1IP1 | K7GSP8 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | PAK1IP1 | 100357229 | G1T599 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Pak1ip1 | 361232 | Q32PZ0 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pak1ip1 | 336470 | Q6TNS2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005730 | nucleolus |
| GO:0009968 | negative regulation of signal transduction |
| GO:0042273 | ribosomal large subunit biogenesis |
| Pfam ID | Pfam Term |
|---|---|
| PF00400 | WD40 |