Gene: Pak1ip1

Basic information

Tag Content
Uniprot ID Q9DCE5; Q3UBK7; Q80UT4; Q8C5N6; Q923K2; Q9D3E9;
Entrez ID 68083
Genbank protein ID AAK51599.1; AAH51498.1; AAL40652.1; BAC37076.1; BAE29818.1; BAE29957.1; BAB22407.1;
Genbank nucleotide ID NM_026550.3
Ensembl protein ID ENSMUSP00000040846
Ensembl nucleotide ID ENSMUSG00000038683
Gene name p21-activated protein kinase-interacting protein 1
Gene symbol Pak1ip1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 23935987
Functional description Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
Sequence
MELVAGSYEQ VLFGFTVQRG PAKSGHQETW TPVADFTHHS HTASLSVLAS NSRYVVSGSK 60
DETIHIYDMK RKVEHGALVH HAGTVTCLKF HGNQHLISGA EDGHICIWDV KRWKCLKTFK 120
AHRGHVTFLS IHPSGKLALS VGTDKTLRTW NLIEGRSAFI KNIKENAHIV EWSPSGGKYI 180
VVVQNKVDVY RLGTASVSGT ITNGKRISSV TFLSDSVLAV AGDEEVVRIF DCDSLECLCE 240
FRAHENRVKD MVSFEVPDHH VLVTASNDGF IKMWTLPQDK KVPPSLLCEA KTGARLTCLT 300
VWLDRAANGM ASLPPAAEPC PDQPKTIEKE SGDTVQEETS EPNSEKSDVS GDSKQPTKGN 360
SPVTAKKRKM ATMSEKKRKK KM 382

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPAK1IP1102178321A0A452FB78Capra hircusPredictionMore>>
1:1 orthologPAK1IP155003Q9NWT1Homo sapiensPredictionMore>>
1:1 orthologPak1ip168083Q9DCE5CPOMus musculusPublicationMore>>
1:1 orthologPAK1IP1463143H2QSA5Pan troglodytesPredictionMore>>
1:1 orthologPAK1IP1K7GSP8Sus scrofaPredictionMore>>
1:1 orthologPAK1IP1100357229G1T599Oryctolagus cuniculusPredictionMore>>
1:1 orthologPak1ip1361232Q32PZ0Rattus norvegicusPredictionMore>>
1:1 orthologpak1ip1336470Q6TNS2Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI

GO:Biological Process

GO ID GO Term Evidence
GO:0008283 cell population proliferationIPI
GO:0009968 negative regulation of signal transductionIEA
GO:0042273 ribosomal large subunit biogenesisISS
GO:0042273 ribosomal large subunit biogenesisISO
GO:0060021 roof of mouth developmentIMP
GO:1901796 regulation of signal transduction by p53 class mediatorISS
GO:1901796 regulation of signal transduction by p53 class mediatorISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005730 nucleolusISO
GO:0005730 nucleolusIDA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0677 Repeat
KW-0690 Ribosome biogenesis
KW-0734 Signal transduction inhibitor
KW-0853 WD repeat

Interpro

InterPro ID InterPro Term
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

PROSITE

PROSITE ID PROSITE Term
PS00678 WD_REPEATS_1
PS50082 WD_REPEATS_2
PS50294 WD_REPEATS_REGION

Pfam

Pfam ID Pfam Term
PF00400 WD40

Protein-protein interaction

Protein-miRNA interaction