| Tag | Content |
|---|---|
| Uniprot ID | Q801E1 |
| Entrez ID | 373869 |
| Genbank protein ID | AAO32142.1 |
| Genbank nucleotide ID | NM_194409.1 |
| Ensembl protein ID | ENSDARP00000076061 |
| Ensembl nucleotide ID | ENSDARG00000058702 |
| Gene name | Ventral anterior homeobox 2 |
| Gene symbol | vax2 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcription factor that may function in dorsoventral specification of the forebrain. Required for closure of the choroid fissure and together with vax1 is required for optic nerve differentiation and to limit retinal development to the optic cup. |
| Sequence | MFDQATSMGD GIAEDRNHCG SNSLCRDRGR ESKSRTEVGN RSPVQSSTDT PGTSASTPTS 60 SSEDGHDKLL GVDPDYCRRI LVRDAKGTIR EIVLPKGLDL DRPKRTRTSF TAEQLYRLEL 120 EFQRCQYVVG RERTELARQL NLSETQVKVW FQNRRTKQKK DQTKDTDKRS SSTSESLATC 180 NILRLLEQGR LLSVPAPPPN PLLAHPHPGN GSLLGSPSVS TSSGVSSSTT PPGAGSGTFG 240 LSLSSLSGTP PSPRLGVPPP SLCFTMPLLS GAHHELPSGY GCGTSAFEPY MRIERKDGEL 300 GGKKTVS 307 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | VAX2 | 539808 | E1BBM6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | VAX2 | 102188324 | A0A452E6B0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | VAX2 | 25806 | Q9UIW0 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Vax2 | 24113 | Q9WTP9 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | VAX2 | A0A2I3SNN0 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | VAX2 | F1SLE1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Vax2 | G3V7R0 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | vax2 | 373869 | Q801E1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0007417 | central nervous system development |
| GO:0061386 | closure of optic fissure |
| GO:0030900 | forebrain development |
| GO:1902254 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| GO:0030182 | neuron differentiation |
| GO:0021554 | optic nerve development |
| GO:0090259 | regulation of retinal ganglion cell axon guidance |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0060041 | retina development in camera-type eye |
| GO:0060042 | retina morphogenesis in camera-type eye |
| GO:0007601 | visual perception |
| GO:0016055 | Wnt signaling pathway |
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |