Gene: Cyria

Basic information

Tag Content
Uniprot ID Q8BHZ0
Entrez ID 76820
Genbank protein ID BAC32969.1; AAH49664.1; AAH52465.1;
Genbank nucleotide ID XM_006515248.3; XM_006515247.3; NM_029758.4; XM_006515246.3; NM_001146119.1;
Ensembl protein ID ENSMUSP00000152252; ENSMUSP00000065613; ENSMUSP00000068125;
Ensembl nucleotide ID ENSMUSG00000020589
Gene name CYFIP-related Rac1 interactor A
Gene symbol Cyria
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description May negatively regulate RAC1 signaling and RAC1-driven cytoskeletal remodeling. May regulate chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions.
Sequence
MGNLLKVLTR EIENYPHFFL DFENAQPTEG EREIWNQISA VLQDSESILT DLQAYKGAGP 60
EIRDAIQNPN DIQLQEKAWN AVCPLVVRLK RFYEFSIRLE KALQSLLESL TCPPYTPTQH 120
LEREQALAKE FAEILHFTLR FDELKMRNPA IQNDFSYYRR TISRNRINNM HLDIENEVNN 180
EMANRMSLFY AEATPMLKTL SNATMHFVSE NKTLPIENTT DCLSTMTSVC KVMLETPEYR 240
SRFTSEETLM FCMRVMVGVI ILYDHVHPVG AFCKTSKIDM KGCIKVLKEQ APDSVEGLLN 300
ALRFTTKHLN DESTSKQIRA MLQ 323

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCYRIA504763Q17QT7Bos taurusPredictionMore>>
1:1 orthologCYRIA475673E2QRS9Canis lupus familiarisPredictionMore>>
1:1 orthologFAM49A102179293A0A452F6L7Capra hircusPredictionMore>>
1:1 orthologCYRIA81553Q9H0Q0Homo sapiensPublicationMore>>
1:1 orthologCyria76820Q8BHZ0Mus musculusPredictionMore>>
1:1 orthologCYRIA459044H2QHG7Pan troglodytesPredictionMore>>
1:1 orthologCYRIA100518011F2Z5E7Sus scrofaPredictionMore>>
1:1 orthologFam49a298890B0BN65Rattus norvegicusPredictionMore>>
1:1 orthologfam49a378872Q5TZ57Danio rerioPredictionMore>>

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0003674 molecular_functionND

GO:Biological Process

GO ID GO Term Evidence
GO:0008150 biological_processND

GO:Cellular Component

GO ID GO Term Evidence

Reactome Pathway

Reactome ID Reactome Term Evidence

Drugs and compounds information

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Functional annotations

Keywords

Keyword ID Keyword Term
KW-0449 Lipoprotein
KW-0472 Membrane
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR009828 DUF1394
IPR039789 FAM49

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF07159 DUF1394