CleftGeneDB-Search

Gene: Tgds

Basic information

Tag	Content
Uniprot ID	Q8VDR7; Q3U4A6;
Entrez ID	76355
Genbank protein ID	AAH21419.1; BAE32527.1;
Genbank nucleotide ID	NM_029578.3
Ensembl protein ID	ENSMUSP00000022727
Ensembl nucleotide ID	ENSMUSG00000022130
Gene name	dTDP-D-glucose 4,6-dehydratase
Gene symbol	Tgds
Organism	Mus musculus
NCBI taxa ID	10090
Cleft type	CPO
Developmental stage
Data sources	Manually collected
Reference	29208648
Functional description
Sequence	MSAASREERS GPPGSFAKRV LVTGGAGFIA SHVIVSLVED YPDYMIVNLD KLDYCASLKN 60 LEPVSNKQNY KFIQGDICDS HFVKLLFEVE KIDIVLHFAA QTHVDLSFVR AFEFTYVNVY 120 GTHVLVNAAY EAGVEKFIYV STDEVYGGSL DQEFDESSPK QPTNPYASSK AAAECFVQSY 180 WERYKFPVVI TRSSNVYGPH QYPEKVIPKF ISLLQHNRKC CIHGSGLQRR NFLYAADVVE 240 AFLTVLTKGE PGEIYNIGTN FEMSVVQLAK ELIQLIKETN SESETESWVD YVSDRPHNDM 300 RYPMKSEKIH SLGWKPKVPW EEGIKKTVEW YRKNFHNWKN AEKALEPFPV QPPFM 355

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	TGDS	534594	A6QLW2			Bos taurus	Prediction	More>>
1:1 ortholog	TGDS	485521	E2QWQ8			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	TGDS	102170331	A0A452FWY8			Capra hircus	Prediction	More>>
1:1 ortholog	TGDS	23483	O95455			Homo sapiens	Prediction	More>>
1:1 ortholog	Tgds	76355	Q8VDR7	CPO		Mus musculus	Publication	More>>
1:1 ortholog	TGDS	467299	H2Q7P8			Pan troglodytes	Prediction	More>>
1:1 ortholog	TGDS		F1RP60			Sus scrofa	Prediction	More>>
1:1 ortholog	TGDS	100354182	G1SYY5			Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Tgds		A0A0G2JZS4			Rattus norvegicus	Prediction	More>>

Other genetic variants/mutations

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0003674	molecular_function	ND
GO:0008460	dTDP-glucose 4,6-dehydratase activity	IEA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0008150	biological_process	ND
GO:0009225	nucleotide-sugar metabolic process	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005575	cellular_component	ND

Reactome Pathway

Reactome ID	Reactome Term	Evidence

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0456	Lyase
KW-0520	NAD
KW-1185	Reference proteome

Interpro

InterPro ID	InterPro Term
IPR005888	dTDP_Gluc_deHydtase
IPR016040	NAD(P)-bd_dom
IPR036291	NAD(P)-bd_dom_sf

PROSITE

PROSITE ID	PROSITE Term

Pfam

Pfam ID	Pfam Term
PF16363	GDP_Man_Dehyd

Protein-miRNA interaction