Gene: Stx18

Basic information

Tag Content
Uniprot ID Q8VDS8; Q3TDJ0; Q9D8T6;
Entrez ID 71116
Genbank protein ID BAE41033.1; AAH21362.1; BAE41611.1; BAB25198.1;
Genbank nucleotide ID NM_001289535.1; NM_026959.3; NM_001289536.1;
Ensembl protein ID ENSMUSP00000038205; ENSMUSP00000031008; ENSMUSP00000109761;
Ensembl nucleotide ID ENSMUSG00000029125
Gene name Syntaxin-18
Gene symbol Stx18
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
Sequence
MAVDITLLFR ASVKTVKTRN KALGVAVGGG ADGSRDELFR RSPRPKGDFS SRAREVISHI 60
GKLRDFLLEH RKEYINAYSH TMSDYGRMTD TERDQIDQDA QIFIRTCSEA IHQLRTEAHK 120
EIHSQQVKEH RTAVLDFVDD YLKRVCKLYS EQRAIRVKRV VDKKRLSKLE PEPHTKRKDS 180
TSEKAPQNAS QDSEGKPAAE ELPEKPLAES QPELGTWGDG KGEDELSPEE IQMFEQENQR 240
LIGEMNSLFD EVRQIEGKVV EISRLQEIFT EKVLQQETEI DSIHQLVVGA TENIKEGNED 300
IREAIKNNAG FRVWILFFLV MCSFSLLFLD WYDS 334

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSTX18609342J9P4H8Canis lupus familiarisPredictionMore>>
1:1 orthologSTX18A0A452FDT2Capra hircusPredictionMore>>
1:1 orthologSTX1853407Q9P2W9Homo sapiensPublicationMore>>
1:1 orthologStx1871116Q8VDS8Mus musculusPredictionMore>>
1:1 orthologSTX18741790K6Z7Y3Pan troglodytesPredictionMore>>
1:1 orthologSTX18A0A286ZVN3Sus scrofaPredictionMore>>
1:1 orthologStx18360953Q68FW4Rattus norvegicusPredictionMore>>
1:1 orthologstx18554130Q4VBI7Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005484 SNAP receptor activityIEA
GO:0019904 protein domain specific bindingIPI

GO:Biological Process

GO ID GO Term Evidence
GO:0006886 intracellular protein transportIEA
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumIBA
GO:0061025 membrane fusionIEA
GO:0090158 endoplasmic reticulum membrane organizationISO
GO:1902117 positive regulation of organelle assemblyISO
GO:1902953 positive regulation of ER to Golgi vesicle-mediated transportISO
GO:1903358 regulation of Golgi organizationISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0000139 Golgi membraneIEA
GO:0005783 endoplasmic reticulumISO
GO:0005783 endoplasmic reticulumIBA
GO:0005789 endoplasmic reticulum membraneIEA
GO:0016021 integral component of membraneIEA
GO:0031201 SNARE complexIBA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-199991 Membrane TraffickingIEA
R-MMU-5653656 Vesicle-mediated transportIEA
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde trafficIEA
R-MMU-6811442 Intra-Golgi and retrograde Golgi-to-ER trafficIEA
R-MMU-8856688 Golgi-to-ER retrograde transportIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0175 Coiled coil
KW-0256 Endoplasmic reticulum
KW-0931 ER-Golgi transport
KW-0333 Golgi apparatus
KW-0472 Membrane
KW-0653 Protein transport
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix
KW-0813 Transport

Interpro

InterPro ID InterPro Term
IPR019529 Syntaxin-18_N
IPR006012 Syntaxin/epimorphin_CS

PROSITE

PROSITE ID PROSITE Term
PS00914 SYNTAXIN

Pfam

Pfam ID Pfam Term
PF10496 Syntaxin-18_N