Gene: Barx1

Basic information

Tag Content
Uniprot ID Q9ER42; O09066; P70159; Q0VF04; Q9ERV2;
Entrez ID 12022
Genbank protein ID AAG18573.1; AAI19050.2; AAI19048.2; CAC10357.1; CAA69257.1;
Genbank nucleotide ID NM_007526.4
Ensembl protein ID ENSMUSP00000021813
Ensembl nucleotide ID ENSMUSG00000021381
Gene name Homeobox protein BarH-like 1
Gene symbol Barx1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 17855428
Functional description Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity. Binds to a regulatory module of the NCAM promoter.
Sequence
MQRPGEPGAA RFGPPEGCAD HRPHRYRSFM IEEILTEPPG PKGAAPAAAA AAAGELLKFG 60
VQALLAARPF HSHLAVLKAE QAAVFKFPLA PLGCSGLGSA LLAAGPGMPG PAGASHLPLE 120
LQLRGKLEAA GSGEPGAKAK KGRRSRTVFT ELQLMGLEKR FEKQKYLSTP DRIDLAESLG 180
LSQLQVKTWY QNRRMKWKKI VLQGGGLESP TKPKGRPKKN SIPTSEQLTE QERAKETEKP 240
AETPGEPSDR NCED 254

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBARX1610486E2RF36Canis lupus familiarisPredictionMore>>
1:1 orthologBARX1A0A452F3S2Capra hircusPredictionMore>>
1:1 orthologBARX156033Q9HBU1Homo sapiensPredictionMore>>
1:1 orthologBarx112022Q9ER42CPOMus musculusPublicationMore>>
1:1 orthologBARX1745472H2R4D7Pan troglodytesPredictionMore>>
1:1 orthologBARX1F1SUC6Sus scrofaPredictionMore>>
1:1 orthologBarx1364680D3ZA67Rattus norvegicusPredictionMore>>
1:1 orthologbarx1553644B2GRF3Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA bindingIBA
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specificIBA

GO:Biological Process

GO ID GO Term Evidence
GO:0006357 regulation of transcription by RNA polymerase IIIBA
GO:0007267 cell-cell signalingIGI
GO:0007267 cell-cell signalingIMP
GO:0009888 tissue developmentIMP
GO:0009888 tissue developmentIBA
GO:0009952 anterior/posterior pattern specificationIMP
GO:0030178 negative regulation of Wnt signaling pathwayIGI
GO:0030178 negative regulation of Wnt signaling pathwayIMP
GO:0030855 epithelial cell differentiationIMP
GO:0045944 positive regulation of transcription by RNA polymerase IIIEA
GO:0048513 animal organ developmentIMP
GO:0048513 animal organ developmentIBA
GO:0048536 spleen developmentIMP
GO:0048856 anatomical structure developmentIMP
GO:0055123 digestive system developmentIMP
GO:0055123 digestive system developmentIBA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusIBA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0804 Transcription
KW-0805 Transcription regulation

Interpro

InterPro ID InterPro Term
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain

Protein-protein interaction

Protein-miRNA interaction