| Tag | Content |
|---|---|
| Uniprot ID | Q9JLB9; Q059N7; Q9D006; Q9JLB7; Q9JLB8; |
| Entrez ID | 58998 |
| Genbank protein ID | AAI32188.1; AAF63687.1; BAB27933.1; AAI25589.1; AAF63685.1; AAF63686.1; |
| Genbank nucleotide ID | NM_021495.4; NM_021496.3; NM_021497.2; |
| Ensembl protein ID | ENSMUSP00000023335; ENSMUSP00000093757; ENSMUSP00000023334; |
| Ensembl nucleotide ID | ENSMUSG00000022656 |
| Gene name | Nectin-3 |
| Gene symbol | Nectin3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. |
| Sequence | MARTPGPAPL CPGGGKAQLS SAFPPAAGLL LPAPTPPPLL LLLIPLLLFS RLCGALAGSI 60 IVEPHVTAVW GKNVSLKCLI EVNETITQIS WEKIHGKSTQ TVAVHHPQYG FSVQGDYQGR 120 VLFKNYSLND ATITLHNIGF SDSGKYICKA VTFPLGNAQS STTVTVLVEP TVSLIKGPDS 180 LIDGGNETVA AVCVAATGKP VAQIDWEGDL GEMESSTTSF PNETATIVSQ YKLFPTRFAR 240 GRRITCVVKH PALEKDIRYS FILDIQYAPE VSVTGYDGNW FVGRKGVNLK CNADANPPPF 300 KSVWSRLDGQ WPDGLLASDN TLHFVHPLTV NYSGVYVCKV SNSLGQRSDQ KVIYISDPPT 360 TTTLQPTVQW HSSPADVQDI ATEHKKLPFP LSTLATLKDD TIGTIIASVV GGALFLVLVS 420 ILAGVFCYRR RRTFRGDYFA KNYIPPSDMQ KESQIDVLHQ DELDSYPDSV KKENKNPVNN 480 LIRKDYLEEP EKTQWNNVEN LTRFERPMDY YEDLKMGMKF VSDERYNESE DGLVSHVDGS 540 VISRREWYV 549 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NECTIN3 | 25945 | Q9NQS3 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Nectin3 | 58998 | Q9JLB9 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | NECTIN3 | 742869 | H2QN30 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Nectin3 | 288124 | D4A5C0 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0038023 | signaling receptor activity | IBA |
| GO:0042802 | identical protein binding | ISO |
| GO:0042803 | protein homodimerization activity | IDA |
| GO:0042803 | protein homodimerization activity | IBA |
| GO:0050839 | cell adhesion molecule binding | ISO |
| GO:0050839 | cell adhesion molecule binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0002089 | lens morphogenesis in camera-type eye | IMP |
| GO:0007155 | cell adhesion | IDA |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | IDA |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | IBA |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | IBA |
| GO:0007286 | spermatid development | IEA |
| GO:0009566 | fertilization | IMP |
| GO:0060042 | retina morphogenesis in camera-type eye | IMP |
| GO:0061951 | establishment of protein localization to plasma membrane | IMP |
| GO:0098609 | cell-cell adhesion | IDA |
| GO:1902414 | protein localization to cell junction | IDA |
| GO:1902414 | protein localization to cell junction | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005886 | plasma membrane | IDA |
| GO:0005911 | cell-cell junction | IDA |
| GO:0005912 | adherens junction | IDA |
| GO:0005912 | adherens junction | IBA |
| GO:0030424 | axon | ISO |
| GO:0030425 | dendrite | ISO |
| GO:0043296 | apical junction complex | IDA |
| GO:0043296 | apical junction complex | IBA |
| GO:0044291 | cell-cell contact zone | IDA |
| GO:0045202 | synapse | ISO |
| GO:0098686 | hippocampal mossy fiber to CA3 synapse | IDA |
| GO:0099061 | integral component of postsynaptic density membrane | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1500931 | Cell-Cell communication | IEA |
| R-MMU-418990 | Adherens junctions interactions | IEA |
| R-MMU-420597 | Nectin/Necl trans heterodimerization | IEA |
| R-MMU-421270 | Cell-cell junction organization | IEA |
| R-MMU-446728 | Cell junction organization | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0025 | Alternative splicing |
| KW-0130 | Cell adhesion |
| KW-0965 | Cell junction |
| KW-1003 | Cell membrane |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0393 | Immunoglobulin domain |
| KW-0472 | Membrane |
| KW-0628 | Postsynaptic cell membrane |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0770 | Synapse |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50835 | IG_LIKE |