| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 3156 |
Name | HMGCR |
Synonym | LDLCQ3;3-hydroxy-3-methylglutaryl-CoA reductase;HMGCR;3-hydroxy-3-methylglutaryl-CoA reductase |
Definition | 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)|3-hydroxy-3-methylglutaryl-Coenzyme A reductase|HMG-CoA reductase|hydroxymethylglutaryl-CoA reductase |
Position | 5q13.3-q14 |
Gene Type | protein-coding |
|
PAH Type |
Description |
PAH | We conclude that simvastatin attenuates and induces regression of established CHPH through inhibition of HMG-CoA reductase. Inhibition of ROCK expression and activity may be an important mechanism of statin effect. |
| More detail of all Human literatures about HMGCR | |
|
Pathways and Diseases |
|
Pathway | Cholesterol biosynthesis;PANTHER;P00014 |
Pathway | superpathway of cholesterol biosynthesis;BioCyc;PWY66-5 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | mevalonate degradation;BioCyc;PWY-5074 |
Pathway | Terpenoid backbone biosynthesis;KEGG PATHWAY;hsa00900 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | mevalonate pathway I;BioCyc;PWY-922 |
Pathway | superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate);BioCyc;PWY-5910 |
Disease | Statins, attenuated cholesterol lowering by;OMIM |
Disease | LDL cholesterol;GAD |
Disease | Alzheimer's disease cognitive function;GAD |
Disease | LDL cholesterol;NHGRI |
Disease | atherosclerosis, coronary;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Stroke;GAD |
Disease | lipids;GAD |
Disease | quantitative traits;GAD |
Disease | Diabetes Mellitus;GAD |
Disease | cholesterol, total;GAD |
Disease | METABOLIC;GAD |
Disease | Cholesterol, total;NHGRI |
Disease | Atherosclerosis;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | Low density lipoprotein cholesterol level QTL 3;OMIM |
|
External Links |
|
Links to Entrez Gene | 3156 |
Links to all GeneRIF Items | 3156 |
Links to iHOP | 3156 |
|
Sequence Information |
|
Nucleotide Sequence |
>3156 : length: 2667 atgttgtcaagactttttcgaatgcatggcctctttgtggcctcccatccctgggaagtc atagtggggacagtgacactgaccatctgcatgatgtccatgaacatgtttactggtaac aataagatctgtggttggaattatgaatgtccaaagtttgaagaggatgttttgagcagt gacattataattctgacaataacacgatgcatagccatcctgtatatttacttccagttc cagaatttacgtcaacttggatcaaaatatattttgggtattgctggccttttcacaatt ttctcaagttttgtattcagtacagttgtcattcacttcttagacaaagaattgacaggc ttgaatgaagctttgccctttttcctacttttgattgacctttccagagcaagcacatta gcaaagtttgccctcagttccaactcacaggatgaagtaagggaaaatattgctcgtgga atggcaattttaggtcctacgtttaccctcgatgctcttgttgaatgtcttgtgattgga gttggtaccatgtcaggggtacgtcagcttgaaattatgtgctgctttggctgcatgtca gttcttgccaactacttcgtgttcatgactttcttcccagcttgtgtgtccttggtatta gagctttctcgggaaagccgcgagggtcgtccaatttggcagctcagccattttgcccga gttttagaagaagaagaaaataagccgaatcctgtaactcagagggtcaagatgattatg tctctaggcttggttcttgttcatgctcacagtcgctggatagctgatccttctcctcaa aacagtacagcagatacttctaaggtttcattaggactggatgaaaatgtgtccaagaga attgaaccaagtgtttccctctggcagttttatctctctaaaatgatcagcatggatatt gaacaagttattaccctaagtttagctctccttctggctgtcaagtacatcttctttgaa caaacagagacagaatctacactctcattaaaaaaccctatcacatctcctgtagtgaca caaaagaaagtcccagacaattgttgtagacgtgaacctatgctggtcagaaataaccag aaatgtgattcagtagaggaagagacagggataaaccgagaaagaaaagttgaggttata aaacccttagtggctgaaacagataccccaaacagagctacatttgtggttggtaactcc tccttactcgatacttcatcagtactggtgacacaggaacctgaaattgaacttcccagg gaacctcggcctaatgaagaatgtctacagatacttgggaatgcagagaaaggtgcaaaa ttccttagtgatgctgagatcatccagttagtcaatgctaagcatatcccagcctacaag ttggaaactctgatggaaactcatgagcgtggtgtatctattcgccgacagttactttcc aagaagctttcagaaccttcttctctccagtacctaccttacagggattataattactcc ttggtgatgggagcttgttgtgagaatgttattggatatatgcccatccctgttggagtg gcaggacccctttgcttagatgaaaaagaatttcaggttccaatggcaacaacagaaggt tgtcttgtggccagcaccaatagaggctgcagagcaataggtcttggtggaggtgccagc agccgagtccttgcagatgggatgactcgtggcccagttgtgcgtcttccacgtgcttgt gactctgcagaagtgaaagcctggctcgaaacatctgaagggttcgcagtgataaaggag gcatttgacagcactagcagatttgcacgtctacagaaacttcatacaagtatagctgga cgcaacctttatatccgtttccagtccaggtcaggggatgccatggggatgaacatgatt tcaaagggtacagagaaagcactttcaaaacttcacgagtatttccctgaaatgcagatt ctagccgttagtggtaactattgtactgacaagaaacctgctgctataaattggatagag ggaagaggaaaatctgttgtttgtgaagctgtcattccagccaaggttgtcagagaagta ttaaagactaccacagaggctatgattgaggtcaacattaacaagaatttagtgggctct gccatggctgggagcataggaggctacaacgcccatgcagcaaacattgtcaccgccatc tacattgcctgtggacaggatgcagcacagaatgttggtagttcaaactgtattacttta atggaagcaagtggtcccacaaatgaagatttatatatcagctgcaccatgccatctata gagataggaacggtgggtggtgggaccaacctactacctcagcaagcctgtttgcagatg ctaggtgttcaaggagcatgcaaagataatcctggggaaaatgcccggcagcttgcccga attgtgtgtgggaccgtaatggctggggaattgtcacttatggcagcattggcagcagga catcttgtcaaaagtcacatgattcacaacaggtcgaagatcaatttacaagacctccaa ggagcttgcaccaagaagacagcctga |
Protein Sequence |
>3156 : length: 888 MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA |