| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3156 |
Name | HMGCR |
Synonymous | LDLCQ3;3-hydroxy-3-methylglutaryl-CoA reductase;HMGCR;3-hydroxy-3-methylglutaryl-CoA reductase |
Definition | 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)|3-hydroxy-3-methylglutaryl-Coenzyme A reductase|HMG-CoA reductase|hydroxymethylglutaryl-CoA reductase |
Position | 5q13.3-q14 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for HMGCR | |||
Transcription Factors [Top] |
Regulation From TransFac database | HMGCR(h) --> 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform-1(h) (expression). | STA13-isoform1(h) + 3-hydroxy-3-methylglutaryl-coenzyme A reductase(h) <==> STA13-isoform1(h):3-hydroxy-3-methylglutaryl-coenzyme A reductase(h) (binding) | Gp78-isoform2(h) + insig-1(h) + 3-hydroxy-3-methylglutaryl-coenzyme A reductase(h) <==> Gp78-isoform2(h):insig-1(h):3-hydroxy-3-methylglutaryl-coenzyme A reductase(h) (binding) | 3-hydroxy-3-methylglutaryl-coenzyme A reductase(h) + n ubiquitin(h) --Gp78(h)--> 3-hydroxy-3-methylglutaryl-coenzyme A reductase(h){ub}n (ubiquitination) | 3-hydroxy-3-methylglutaryl-coenzyme A reductase(h) + ubiquitin(h) --> 3-hydroxy-3-methylglutaryl-coenzyme A reductase(h){ub} (ubiquitination) | HMGCR(h) --> 3-hydroxy-3-methylglutaryl-coenzyme A reductase(h) (expression). | 3-hydroxy-3-methylglutaryl-coenzyme A reductase-isoform2(h) --> protein remnants (degradation) | HMGCR(h) --> 3-hydroxy-3-methylglutaryl-coenzyme A reductase-isoform2(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 281 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 296 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 419 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 518 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 870 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr5 |
Promoter: 74667355 - 74669355 | Agilent_014791 |
chr5 |
Promoter: 74667355 - 74669355 | GSE27584 |
chr5 |
Promoter: 74667355 - 74669355 | Agilent_014791_44K |