| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 5163 |
Name | PDK1 |
Synonym | -;pyruvate dehydrogenase kinase, isozyme 1;PDK1;pyruvate dehydrogenase kinase, isozyme 1 |
Definition | PDH kinase 1|mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1|pyruvate dehydrogenase kinase, isoenzyme 1 |
Position | 2q31.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "Pyruvate dehydrogenase kinase (PDK) is pathologically activated in both conditions. This enzyme phosphorylates and inhibits pyruvate dehydrogenase (PDH). PDH catalyses the irreversible oxidation of pyruvate, yielding acetylCoA and CO2 and is a key enzyme controlling the rate of oxidative metabolism. PDK activation thus impairs the Krebs' cycle and creates a glycolytic shift in glucose metabolism. ". |
| More detail of all Human literatures about PDK1 | |
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Pathways and Diseases |
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Pathway | Pyruvate metabolism and Citric Acid (TCA) cycle;Reactome;REACT:1046 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
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External Links |
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Links to Entrez Gene | 5163 |
Links to all GeneRIF Items | 5163 |
Links to iHOP | 5163 |
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Sequence Information |
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Nucleotide Sequence |
>5163 : length: 1311 atgaggctggcgcggctgcttcgcggagccgccttggccggcccgggcccggggctgcgc gccgccggcttcagccgcagcttcagctcggactcgggctccagcccggcgtccgagcgc ggcgttccgggccaggtggacttctacgcgcgcttctcgccgtccccgctctccatgaag cagttcctggacttcggatcagtgaatgcttgtgaaaagacctcatttatgtttctgcgg caagagttgcctgtcagactggcaaatataatgaaagaaataagtctccttccagataat cttctcaggacaccatccgttcaattggtacaaagctggtatatccagagtcttcaggag cttcttgattttaaggacaaaagtgctgaggatgctaaagctatttatgactttacagat actgtgatacggatcagaaaccgacacaatgatgtcattcccacaatggcccagggtgtg attgaatacaaggagagctttggggtggatcctgtcaccagccagaatgttcagtacttt ttggatcgattctacatgagtcgcatttcaattagaatgttactcaatcagcactcttta ttgtttggtggaaaaggcaaaggaagtccatctcatcgaaaacacattggaagcataaat ccaaactgcaatgtacttgaagttattaaagatggctatgaaaatgctaggcgtctgtgt gatttgtattatattaactctcccgaactagaacttgaagaactaaatgcaaaatcacca ggacagccaatacaagtggtttatgtaccatcccatctctatcacatggtgtttgaactt ttcaagaatgcaatgagagccactatggaacaccatgccaacagaggtgtttacccccct attcaagttcatgtcacgctgggtaatgaggatttgactgtgaagatgagtgaccgagga ggtggcgttcctttgaggaaaattgacagacttttcaactacatgtattcaactgcacca agacctcgtgttgagacctcccgcgcagtgcctctggctggttttggttatggattgccc atatcacgtctttacgcacaatacttccaaggagacctgaagctgtattccctagagggt tacgggacagatgcagttatctacattaaggctctgtcaacagactcaatagaaagactc ccagtgtataacaaagctgcctggaagcattacaacaccaaccacgaggctgatgactgg tgcgtccccagcagagaacccaaagacatgacgacgttccgcagtgcctag |
Protein Sequence |
>5163 : length: 436 MRLARLLRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMK QFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQE LLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYF LDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLC DLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPP IQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLP ISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDW CVPSREPKDMTTFRSA |