| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5592 |
Name | PRKG1 |
Synonym | 1|PKG|PRKG1B|PRKGR1B|cGK|cGK 1|cGK1|cGKI|cGKI-BETA|cGKI-alpha;protein kinase, cGMP-dependent, type I;PRKG1;protein kinase, cGMP-dependent, type I |
Definition | cGMP-dependent protein kinase 1|protein kinase, cGMP-dependent, regulatory, type I, beta |
Position | 10q11.2 |
Gene Type | protein-coding |
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PAH Type |
Description |
PH | PKG-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation-mediated vasoconstriction and pulmonary vascular remodeling. |
| More detail of all Mouse literatures about PRKG1 | |
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Pathways and Diseases |
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Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Olfactory transduction;KEGG PATHWAY;hsa04740 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | Long-term depression;KEGG PATHWAY;hsa04730 |
Pathway | Salivary secretion;KEGG PATHWAY;hsa04970 |
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External Links |
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Links to Entrez Gene | 5592 |
Links to all GeneRIF Items | 5592 |
Links to iHOP | 5592 |
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Sequence Information |
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Nucleotide Sequence |
>5592 : length: 2016 atgagcgagctagaggaagactttgccaagattctcatgctcaaggaggagaggatcaaa gagctggagaagcggctgtcagagaaggaggaagaaattcaggagctgaagaggaaactc cacaaatgccagtcggtgctcccagtgccctcgacccacatcggcccccggaccacccgg gcgcagggcatctcggccgagccgcagacgtacaggtccttccacgacctccgacaggca ttccggaagttcaccaagtccgaaaggtccaaggatcttataaaggaagctatccttgac aatgactttatgaagaacttggagctgtcgcagatccaggagattgtggattgtatgtac ccggtggagtatggcaaggacagttgcatcatcaaagaaggagacgtggggtcactggtg tatgtcatggaagatggtaaggttgaagttacaaaagaaggtgtgaagttgtgtaccatg ggtccaggaaaagtgtttggggaattggctattctttacaactgtacccggacagcgacc gtcaagactcttgtaaatgtaaaactctgggccattgatcgacaatgttttcaaacaata atgatgaggacaggactcatcaagcataccgagtatatggaatttttaaaaagcgttcca acattccagagccttcctgaagagatcctcagcaagcttgctgatgtccttgaagagacc cactatgaaaatggagaatatattatcaggcaaggtgcaagaggggacaccttctttatc atcagcaaaggaacggtaaatgtcactcgtgaagactcaccgagtgaagacccagtcttt cttagaactttaggaaaaggagactggtttggagagaaagccttgcagggggaagatgtg agaacagcaaacgtaattgctgcagaagctgtaacctgccttgtgattgacagagactct tttaaacatttgattggagggctggatgatgtttctaataaagcatatgaagatgcagaa gctaaagcaaaatatgaagctgaagcggctttcttcgccaacctgaagctgtctgatttc aacatcattgatacccttggagttggaggtttcggacgagtagaactggtccagttgaaa agtgaagaatccaaaacgtttgcaatgaagattctcaagaaacgtcacattgtggacaca agacagcaggagcacatccgctcagagaagcagatcatgcagggggctcattccgatttc atagtgagactgtacagaacatttaaggacagcaaatatttgtatatgttgatggaagct tgtctaggtggagagctctggaccattctcagggatagaggttcgtttgaagattctaca accagattttacacagcatgtgtggtagaagcttttgcctatctgcattccaaaggaatc atttacagggacctcaagccagaaaatctcatcctagatcaccgaggttatgccaaactg gttgattttggctttgcaaagaaaataggatttggaaagaaaacatggactttttgtggg actccagagtatgtagccccagagatcatcctgaacaaaggccatgacatttcagccgac tactggtcactgggaatcctaatgtatgaactcctgactggcagcccacctttctcaggc ccagatcctatgaaaacctataacatcatattgagggggattgacatgatagaatttcca aagaagattgccaaaaatgctgctaatttaattaaaaaactatgcagggacaatccatca gaaagattagggaatttgaaaaatggagtaaaagacattcaaaagcacaaatggtttgag ggctttaactgggaaggcttaagaaaaggtaccttgacacctcctataataccaagtgtt gcatcacccacagacacaagtaattttgacagtttccctgaggacaacgatgaaccacca cctgatgacaactcaggatgggatatagacttctaa |
Protein Sequence |
>5592 : length: 671 MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTR AQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMY PVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTAT VKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEET HYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDV RTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDF NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS ERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPP PDDNSGWDIDF |