| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 5592 |
Name | PRKG1 |
Synonymous | 1|PKG|PRKG1B|PRKGR1B|cGK|cGK 1|cGK1|cGKI|cGKI-BETA|cGKI-alpha;protein kinase, cGMP-dependent, type I;PRKG1;protein kinase, cGMP-dependent, type I |
Definition | cGMP-dependent protein kinase 1|protein kinase, cGMP-dependent, regulatory, type I, beta |
Position | 10q11.2 |
Gene Type | protein-coding |
Gene Mutation: | GWAS results PAH samples Lung cancer |
GWAS results [Top] | ||
|
Variant (Location; Chr; Position; SNP; Allele; Homogeneity) |
Discovery Cohort (Cochran-Armitage Trend Test P-value; P-value from Eigenstrat; MAF cases; MAF controls) |
Replication Cohort (Cochran-Armitage Trend Test P-value; MAF cases; MAF controls) |
|---|---|---|
intron; chr10;53537213;rs11000798;G/A; + - |
3.9113e10-4; 6.4351e10-4; 0.3044; 0.2364 | 0.6839; 0.2281; 0.2374 |
Lung cancer [Top] | ||
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
p.R422P; chr10:54031201-54031201 |
lung | adenocarcinoma; carcinoma |
p.G525V; chr10:54041941-54041941 |
lung | small_cell_carcinoma; carcinoma |
p.G525*; chr10:54041940-54041940 |
lung | small_cell_carcinoma; carcinoma |
p.?; chr10:54040698-54040698 |
lung | adenocarcinoma; carcinoma |
p.R617K; chr10:54048708-54048708 |
lung | adenocarcinoma; carcinoma |
p.Q393H; chr10:54031115-54031115 |
lung | squamous_cell_carcinoma; carcinoma |
p.K162_V163>NF; chr10:53227490-53227491 |
lung | adenocarcinoma; carcinoma |
p.H93N; chr10:52834627-52834627 |
lung | squamous_cell_carcinoma; carcinoma |
p.P83H; chr10:52834598-52834598 |
lung | squamous_cell_carcinoma; carcinoma |
p.S570N; chr10:54042076-54042076 |
lung | adenocarcinoma; carcinoma |
p.K197E; chr10:53227593-53227593 |
lung | squamous_cell_carcinoma; carcinoma |
p.T225T; chr10:53564427-53564427 |
lung | adenocarcinoma; carcinoma |
p.L439M; chr10:54032153-54032153 |
lung | squamous_cell_carcinoma; carcinoma |
p.S288T; chr10:53822318-53822318 |
lung | small_cell_carcinoma; carcinoma |
p.R441I; chr10:54032160-54032160 |
lung | adenocarcinoma; carcinoma |
p.V294F; chr10:53822336-53822336 |
lung | adenocarcinoma; carcinoma |
p.R209R; chr10:53564377-53564377 |
lung | squamous_cell_carcinoma; carcinoma |
p.F573F; chr10:54048495-54048495 |
lung | adenocarcinoma; carcinoma |
p.K630K; chr10:54048748-54048748 |
lung | squamous_cell_carcinoma; carcinoma |
p.G260V; chr10:53814260-53814260 |
lung | squamous_cell_carcinoma; carcinoma |
p.?; chr10:53893597-53893597 |
lung | squamous_cell_carcinoma; carcinoma |
p.E148D; chr10:52913056-52913056 |
lung | small_cell_carcinoma; carcinoma |
p.V294V; chr10:53822338-53822338 |
lung | adenocarcinoma; carcinoma |
p.T280T; chr10:53814321-53814321 |
lung | carcinoma |
p.P502S; chr10:54040649-54040649 |
lung | adenocarcinoma; carcinoma |
p.P675T; chr10:54053622-54053622 |
lung | small_cell_carcinoma; carcinoma |
p.M175I; chr10:53227529-53227529 |
lung | squamous_cell_carcinoma; carcinoma |