| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5743 |
Name | PTGS2 |
Synonym | COX-2|COX2|GRIPGHS|PGG/HS|PGHS-2|PHS-2|hCox-2;prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase);PTGS2;prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
Definition | PGH synthase 2|PHS II|cyclooxygenase 2b|prostaglandin G/H synthase 2|prostaglandin H2 synthase 2 |
Position | 1q25.2-q25.3 |
Gene Type | protein-coding |
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PAH Type |
Description |
HPH | Changes of expressions of COX-2 mRNA may regulate hypoxic hypercapnic pulmonary hypertension. |
PH | "Both bosentan and tezosentan reduced ET-1 and cytokine plasma levels and tissue expression, and inducible NOS and COX-2 RV activities". |
| More detail of all Rat literatures about PTGS2 | |
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Pathways and Diseases |
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Pathway | VEGF signaling pathway;KEGG PATHWAY;hsa04370 |
Pathway | Calcium signaling in the CD4+ TCR pathway;PID Curated;200159 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | S1P1 pathway;PID Curated;200071 |
Pathway | Hormone biosynthesis;Reactome;REACT:15314 |
Pathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes;PID Curated;200039 |
Pathway | COX reactions;PID Reactome;500205 |
Pathway | Prostanoid metabolism;PID Reactome;500770 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | Biological oxidations;Reactome;REACT:13433 |
Pathway | Signaling mediated by p38-alpha and p38-beta;PID Curated;200154 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | prostanoid biosynthesis;BioCyc;PWY66-374 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | C-MYB transcription factor network;PID Curated;200130 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Arachidonic acid metabolism;KEGG PATHWAY;hsa00590 |
Disease | Ischemia;FunDO |
Disease | Cholangiocarcinoma;KEGG DISEASE;H00046 |
Disease | Alzheimer's disease;GAD |
Disease | Periodontitis;FunDO |
Disease | NEUROLOGICAL;GAD |
Disease | Asthma;FunDO |
Disease | Cancer;FunDO |
Disease | Polyarthritis;FunDO |
Disease | Oral cancer;FunDO |
Disease | bladder cancer;GAD |
Disease | Sickle cell disease;FunDO |
Disease | Parkinson disease;FunDO |
Disease | Esophageal Neoplasms;GAD |
Disease | stroke, atherothrombotic;GAD |
Disease | Chronic fatigue syndrome;FunDO |
Disease | lung cancer;GAD |
Disease | cervical cancer;GAD |
Disease | IMMUNE;GAD |
Disease | Rheumatoid arthritis;FunDO |
Disease | cardiovascular disease;GAD |
Disease | prostate cancer;GAD |
Disease | PHARMACOGENOMIC;GAD |
Disease | Dental plaque;FunDO |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | Stroke;FunDO |
Disease | Alzheimer's disease;FunDO |
Disease | colorectal cancer;GAD |
Disease | METABOLIC;GAD |
Disease | diabetes, type 2;GAD |
Disease | placental malperfusion pregnancy complications;GAD |
Disease | Knee osteoarthritis;NHGRI |
Disease | REPRODUCTION;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Penile cancer;KEGG DISEASE;H00025 |
Disease | Vulvar disease;FunDO |
Disease | Myocardial Infarction;GAD |
Disease | analgesic response;GAD |
Disease | Endometriosis;FunDO |
Disease | Prion disease;FunDO |
Disease | skin cancer, non-melanoma;GAD |
Disease | Growth retardation;FunDO |
Disease | Cancers;KEGG DISEASE |
Disease | knee osteoarthritis;GAD |
Disease | Gouts;FunDO |
Disease | colon cancer;GAD |
Disease | Cancers of the urinary system and male genital organs;KEGG DISEASE |
Disease | breast cancer;GAD |
Disease | CANCER;GAD |
Disease | sarcoidosis;GAD |
Disease | stomach cancer;GAD |
Disease | Metaplastic polyp;FunDO |
Disease | Thyroid gland disease;FunDO |
Disease | Carcinoma, Squamous Cell;GAD |
Disease | myocardial infarct;GAD |
Disease | Esophageal cancer;KEGG DISEASE;H00017 |
Disease | Atherosclerosis;FunDO |
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External Links |
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Links to Entrez Gene | 5743 |
Links to all GeneRIF Items | 5743 |
Links to iHOP | 5743 |
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Sequence Information |
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Nucleotide Sequence |
>5743 : length: 1815 atgctcgcccgcgccctgctgctgtgcgcggtcctggcgctcagccatacagcaaatcct tgctgttcccacccatgtcaaaaccgaggtgtatgtatgagtgtgggatttgaccagtat aagtgcgattgtacccggacaggattctatggagaaaactgctcaacaccggaatttttg acaagaataaaattatttctgaaacccactccaaacacagtgcactacatacttacccac ttcaagggattttggaacgttgtgaataacattcccttccttcgaaatgcaattatgagt tatgtgttgacatccagatcacatttgattgacagtccaccaacttacaatgctgactat ggctacaaaagctgggaagccttctctaacctctcctattatactagagcccttcctcct gtgcctgatgattgcccgactcccttgggtgtcaaaggtaaaaagcagcttcctgattca aatgagattgtggaaaaattgcttctaagaagaaagttcatccctgatccccagggctca aacatgatgtttgcattctttgcccagcacttcacgcatcagtttttcaagacagatcat aagcgagggccagctttcaccaacgggctgggccatggggtggacttaaatcatatttac ggtgaaactctggctagacagcgtaaactgcgccttttcaaggatggaaaaatgaaatat cagataattgatggagagatgtatcctcccacagtcaaagatactcaggcagagatgatc taccctcctcaagtccctgagcatctacggtttgctgtggggcaggaggtctttggtctg gtgcctggtctgatgatgtatgccacaatctggctgcgggaacacaacagagtatgcgat gtgcttaaacaggagcatcctgaatggggtgatgagcagttgttccagacaagcaggcta atactgataggagagactattaagattgtgattgaagattatgtgcaacacttgagtggc tatcacttcaaactgaaatttgacccagaactacttttcaacaaacaattccagtaccaa aatcgtattgctgctgaatttaacaccctctatcactggcatccccttctgcctgacacc tttcaaattcatgaccagaaatacaactatcaacagtttatctacaacaactctatattg ctggaacatggaattacccagtttgttgaatcattcaccaggcaaattgctggcagggtt gctggtggtaggaatgttccacccgcagtacagaaagtatcacaggcttccattgaccag agcaggcagatgaaataccagtcttttaatgagtaccgcaaacgctttatgctgaagccc tatgaatcatttgaagaacttacaggagaaaaggaaatgtctgcagagttggaagcactc tatggtgacatcgatgctgtggagctgtatcctgcccttctggtagaaaagcctcggcca gatgccatctttggtgaaaccatggtagaagttggagcaccattctccttgaaaggactt atgggtaatgttatatgttctcctgcctactggaagccaagcacttttggtggagaagtg ggttttcaaatcatcaacactgcctcaattcagtctctcatctgcaataacgtgaagggc tgtccctttacttcattcagtgttccagatccagagctcattaaaacagtcaccatcaat gcaagttcttcccgctccggactagatgatatcaatcccacagtactactaaaagaacgt tcgactgaactgtag |
Protein Sequence |
>5743 : length: 604 MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER STEL |