Entrez Gene

Basic Information
Gene ID	5743
Name	PTGS2
Synonymous	COX-2\|COX2\|GRIPGHS\|PGG/HS\|PGHS-2\|PHS-2\|hCox-2;prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase);PTGS2;prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Definition	PGH synthase 2\|PHS II\|cyclooxygenase 2b\|prostaglandin G/H synthase 2\|prostaglandin H2 synthase 2
Position	1q25.2-q25.3
Gene Type	protein-coding
Gene Regulation:	ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB [Top]
	There is no record for PTGS2

Regulation From TransFac database
Transcription Factors [Top]
2 COX2(h) <==> (COX2(h))2 (binding; oligomerization)
COX2(h) --> PGI2 (increase of secretion)
PTGS2(h) --> COX2(h) (expression).
EGF(h) --> COX2(h) (increase of abundance)
C/EBPdelta(h) --> COX2(h) (increase of abundance)
LPA --> COX2(h) (increase of abundance)
LPA2(h) --> COX2(h) (increase of abundance)
Substance P(m.s.) --> COX2(h) (increase of abundance)
histamine --> COX2(h) (increase of abundance)
LPS --> COX2(h) (increase of abundance)
IL-17A(h) --> COX2(h) (increase of abundance)
ET-1(m.s.) --> COX2(h) (increase of abundance)
ET3(m.s.) --> COX2(h) (increase of abundance)
IFNalpha(m.s.) --> COX2(h) (increase of abundance)
PTGS2(h) --> COX2(h) (expression).
PTGS2(h) --> COX2(h) (expression).
hsa-miR-101 --/ COX2(h) (translational repression).

Location (AA)	PTM type	Database
Post Transcriptional Modification [Top]
53	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
130	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
396	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
580	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0

Chromosome	Location	Source
Methylation Profile [Top]
chr1	Promoter: 184915679 - 184917679	Agilent_014791
chr1	Promoter: 184915679 - 184917679	GoldenGate_Methylation_Cancer_Panel_I
chr1	Promoter: 184915679 - 184917679	GSE27584
chr1	Promoter: 184915679 - 184917679	Agilent_014791_44K
chr1	Promoter: 184915679 - 184917679	PMID:12695555
chr1	Promoter: 184915679 - 184917679	PMID:14550281
chr1	Promoter: 184915679 - 184917679	PMID:11389100
chr1	Promoter: 184915679 - 184917679	PMID:12746473
chr1	Promoter: 184915679 - 184917679	PMID:12684668
chr1	Promoter: 184915679 - 184917679	PMID:12763209
chr1	Promoter: 184915679 - 184917679	PMID:14507661
chr1	Promoter: 184915679 - 184917679	PMID:16949912
chr1	Promoter: 184915679 - 184917679	PMID:11774276
chr1	Promoter: 184915679 - 184917679	PMID:16956712
chr1	Promoter: 184915679 - 184917679	PMID:15026333
chr1	Promoter: 184915679 - 184917679	PMID:16489065
chr1	Promoter: 184915679 - 184917679	PMID:15930345
chr1	Promoter: 184915679 - 184917679	PMID:15899813
chr1	Promoter: 184915679 - 184917679	PMID:17139617
chr1	Promoter: 184915679 - 184917679	PMID:15526363
chr1	Promoter: 184915679 - 184917679	PMID:15122305
chr1	Promoter: 184915679 - 184917679	PMID:16551850
chr1	Promoter: 184915679 - 184917679	PMID:10945606
chr1	Promoter: 184915679 - 184917679	PMID:15156159
chr1	Promoter: 184915679 - 184917679	PMID:12011226
chr1	Promoter: 184915679 - 184917679	PMID:14507645
chr1	Promoter: 184915679 - 184917679	PMID:16565510
chr1	Promoter: 184915679 - 184917679	PMID:12213730
chr1	Promoter: 184915679 - 184917679	PMID:11895880
chr1	Promoter: 184915679 - 184917679	PMID:15639718
chr1	Promoter: 184915679 - 184917679	PMID:16435073
chr1	Promoter: 184915679 - 184917679	PMID:16507389
chr1	Promoter: 184915679 - 184917679	PMID:15172987
chr1	Promoter: 184915679 - 184917679	PMID:12730870
chr1	Promoter: 184915679 - 184917679	PMID:15589597
chr1	Promoter: 184915679 - 184917679	PMID:16242928
chr1	Promoter: 184915679 - 184917679	PMID:15723947

ENCODE RegulomeDB [Top]

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]