| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 7166 |
Name | TPH1 |
Synonym | TPRH|TRPH;tryptophan hydroxylase 1;TPH1;tryptophan hydroxylase 1 |
Definition | L-tryptophan hydroxylase|indoleacetic acid-5-hydroxylase|tryptophan 5-hydroxylase 1|tryptophan 5-monooxygenase 1|tryptophan hydroxylase (tryptophan 5-monooxygenase) |
Position | 11p15.3-p14 |
Gene Type | protein-coding |
PAH Type | Description |
HPH | Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. |
PAH | These results demonstrate that hypoxia induces Tph1 activity and selective knockdown of PAEC-Tph1 attenuates hypoxia-induced PAH in rats. |
PH | Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. |
PH | Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice. |
PH | Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension. |
| More detail of all Mouse literatures about TPH1 | |
Pathways and Diseases | |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Metabolism of amino acids and derivatives;Reactome;REACT:13 |
Pathway | Tryptophan metabolism;KEGG PATHWAY;hsa00380 |
Pathway | Hormone biosynthesis;Reactome;REACT:15314 |
Pathway | serotonin and melatonin biosynthesis;BioCyc;PWY-6030 |
Pathway | 5-Hydroxytryptamine biosynthesis;PANTHER;P04371 |
Disease | anxiety disorder;GAD |
Disease | anger-related traits;GAD |
Disease | Alzheimer's disease;GAD |
Disease | Migraine;FunDO |
Disease | schizophrenia;GAD |
Disease | self-harm behavior;GAD |
Disease | aggressive behavior;GAD |
Disease | personality trait;GAD |
Disease | Depression;FunDO |
Disease | suicide;GAD |
Disease | alcohol abuse;GAD |
Disease | nicotine;GAD |
Disease | PHARMACOGENOMIC;GAD |
Disease | METABOLIC;GAD |
Disease | depressive disorder, major;GAD |
Disease | Autistic disorder;FunDO |
Disease | depression;GAD |
Disease | depressive episode, major;GAD |
Disease | PSYCH;GAD |
Disease | psychosis schizophrenia;GAD |
Disease | CHEMDEPENDENCY;GAD |
Disease | impulsive inpatients;GAD |
Disease | alcoholism;GAD |
Disease | smoking initiation;GAD |
Disease | somatic anxiety;GAD |
Disease | Weight Gain;GAD |
Disease | nicotine dependence;GAD |
Disease | Borderline Personality Disorder;GAD |
Disease | attention deficit hyperactivity disorder;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | Bipolar disorder;FunDO |
Disease | mood disorders;GAD |
Disease | major and bipolar depressives;GAD |
Disease | Hypertension;FunDO |
Disease | major depressive disorder;GAD |
Disease | Thalassemia;FunDO |
Disease | bulimia harm avoidance personality traits;GAD |
Disease | impulsive behavior;GAD |
Disease | Behavior disease;FunDO |
Disease | suicidal behavior;GAD |
Disease | mood disorder;GAD |
External Links | |
Links to Entrez Gene | 7166 |
Links to all GeneRIF Items | 7166 |
Links to iHOP | 7166 |
Sequence Information | |
Nucleotide Sequence | >7166 : length: 1335 atgattgaagacaataaggagaacaaagaccattccttagaaaggggaagagcaagtctc attttttccttaaagaatgaagttggaggacttataaaagccctgaaaatctttcaggag aagcatgtgaatctgttacatatcgagtcccgaaaatcaaaaagaagaaactcagaattt gagatttttgttgactgtgacatcaacagagaacaattgaatgatatttttcatctgctg aagtctcataccaatgttctctctgtgaatctaccagataattttactttgaaggaagat ggtatggaaactgttccttggtttccaaagaagatttctgacctggaccattgtgccaac agagttctgatgtatggatctgaactagatgcagaccatcctggcttcaaagacaatgtc taccgtaaacgtcgaaagtattttgcggacttggctatgaactataaacatggagacccc attccaaaggttgaattcactgaagaggagattaagacctggggaaccgtattccaagag ctcaacaaactctacccaacccatgcttgcagagagtatctcaaaaacttacctttgctt tctaaatattgtggatatcgggaggataatatcccacaattggaagatgtctccaacttt ttaaaagagcgtacaggtttttccatccgtcctgtggctggttacttatcaccaagagat ttcttatcaggtttagcctttcgagtttttcactgcactcaatatgtgagacacagttca gatcccttctataccccagagccagatacctgccatgaactcttaggtcatgtcccgctt ttggctgaacctagttttgcccaattctcccaagaaattggcttggcttctcttggcgct tcagaggaggctgttcaaaaactggcaacgtgctactttttcactgtggagtttggtcta tgtaaacaagatggacagctaagagtctttggtgctggcttactttcttctatcagtgaa ctcaaacatgcactttctggacatgccaaagtaaagccctttgatcccaagattacctgc aaacaggaatgtcttatcacaacttttcaagatgtctactttgtatctgaaagttttgaa gatgcaaaggagaagatgagagaatttaccaaaacaattaagcgtccatttggagtgaag tataatccatatacacggagtattcagatcctgaaagacaccaagagcataaccagtgcc atgaatgagctgcagcatgatctcgatgttgtcagtgatgcccttgctaaggtcagcagg aagccgagtatctaa |
Protein Sequence | >7166 : length: 444 MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA MNELQHDLDVVSDALAKVSRKPSI |