Gene Page: OPRS1

Summary
GeneID  10280
Symbol  OPRS1
Synonyms  FLJ25585|MGC3851|SIGMAR1|SR-BP1
Description  opioid receptor, sigma 1
See related  HGNC:8157|MIM:601978|Ensembl:ENSG00000147955|HPRD:03580|
Locus tag  RP11-443P11.3
Gene type  protein-coding
Map location  9p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenics, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NUP1530.950.97
CKAP50.950.96
SEC31A0.950.95
DYRK1A0.950.96
CNOT10.940.97
STAU10.940.95
PUM10.940.96
HEATR5B0.940.95
C4orf410.930.95
AP1G10.930.95
Top 10 negatively co-expressed genes
MT-CO2-0.81-0.89
AF347015.31-0.80-0.88
FXYD1-0.80-0.88
AF347015.33-0.78-0.85
IFI27-0.77-0.85
MT-CYB-0.77-0.85
HIGD1B-0.76-0.86
AF347015.8-0.76-0.87
AF347015.27-0.76-0.84
AF347015.21-0.75-0.89
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000247C-8 sterol isomerase activityIEA-
GO:0004872receptor activityIEA-
GO:0008144drug bindingTAS8954936 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006696ergosterol biosynthetic processIEA-
GO:0006869lipid transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005634nucleusIEA-
GO:0005637nuclear inner membraneIEA-
GO:0005640nuclear outer membraneIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS8954936 
GO:0012511monolayer-surrounded lipid storage bodyIEA-
GO:0030054cell junctionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANK2DKFZp686M09125 | DKFZp686P0948 | FLJ38277 | LQT4ankyrin 2, neuronal-HPRD,BioGRID11149946 
ITPR3FLJ36205 | IP3R | IP3R3inositol 1,4,5-triphosphate receptor, type 3-HPRD,BioGRID11149946 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PRAMOONJAGO_SOX4_TARGETS_DN 5135All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
OUELLET_CULTURED_OVARIAN_CANCER_INVASIVE_VS_LMP_DN 3520All SZGR genes in this pathway
APPIERTO_RESPONSE_TO_FENRETINIDE_DN 5135All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_DN 3524All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_DN 10371All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_480_MCF10A 3920All SZGR genes in this pathway
ZHOU_TNF_SIGNALING_30MIN 5436All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2 163113All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P2 7955All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
SANSOM_APC_TARGETS_REQUIRE_MYC 210123All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_DN 10563All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1525531m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5065255311Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1535515581A,m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-20512181Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-214116122m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-4485525581Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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