Gene Page: HBS1L
Summary ?
| GeneID | 10767 |
| Symbol | HBS1L |
| Synonyms | EF-1a|ERFS|HBS1|HSPC276|eRF3c |
| Description | HBS1 like translational GTPase |
| Reference | MIM:612450|HGNC:HGNC:4834|Ensembl:ENSG00000112339|HPRD:06582|Vega:OTTHUMG00000015626 |
| Gene type | protein-coding |
| Map location | 6q23.3 |
| Pascal p-value | 0.984 |
| Sherlock p-value | 0.96 |
| Fetal beta | -0.678 |
| DMG | 1 (# studies) |
| eGene | Caudate basal ganglia Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg24665839 | 6 | 135375929 | HBS1L | 2.47E-9 | -0.007 | 1.84E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4646871 | chr6 | 135265616 | HBS1L | 10767 | 1.382E-5 | cis | ||
| rs4472368 | chr6 | 135274231 | HBS1L | 10767 | 9.267E-5 | cis | ||
| rs4289677 | chr6 | 135275484 | HBS1L | 10767 | 6.488E-4 | cis | ||
| rs4896118 | chr6 | 135276064 | HBS1L | 10767 | 6.755E-5 | cis | ||
| rs1014021 | chr6 | 135334599 | HBS1L | 10767 | 0.01 | cis | ||
| rs6923765 | chr6 | 135335175 | HBS1L | 10767 | 0.01 | cis | ||
| rs4896128 | chr6 | 135349755 | HBS1L | 10767 | 6.986E-5 | cis | ||
| rs1590975 | chr6 | 135352087 | HBS1L | 10767 | 0 | cis | ||
| rs9321481 | chr6 | 135352647 | HBS1L | 10767 | 0 | cis | ||
| rs11754265 | chr6 | 135356215 | HBS1L | 10767 | 0.01 | cis | ||
| rs7741515 | chr6 | 135374367 | HBS1L | 10767 | 0 | cis | ||
| rs2150681 | chr6 | 135375231 | HBS1L | 10767 | 0 | cis | ||
| rs1547247 | chr6 | 135390835 | HBS1L | 10767 | 0.05 | cis | ||
| rs4646871 | chr6 | 135265616 | HBS1L | 10767 | 0 | trans | ||
| rs4472368 | chr6 | 135274231 | HBS1L | 10767 | 0.01 | trans | ||
| rs4289677 | chr6 | 135275484 | HBS1L | 10767 | 0.05 | trans | ||
| rs4896118 | chr6 | 135276064 | HBS1L | 10767 | 0.01 | trans | ||
| rs4896128 | chr6 | 135349755 | HBS1L | 10767 | 0.01 | trans | ||
| rs1590975 | chr6 | 135352087 | HBS1L | 10767 | 0.19 | trans | ||
| rs9321481 | chr6 | 135352647 | HBS1L | 10767 | 0.14 | trans | ||
| rs7741515 | chr6 | 135374367 | HBS1L | 10767 | 0.14 | trans | ||
| rs2150681 | chr6 | 135375231 | HBS1L | 10767 | 0.11 | trans | ||
| rs3817776 | 6 | 135256756 | HBS1L | ENSG00000112339.10 | 1.517E-8 | 0 | 167438 | gtex_brain_putamen_basal |
| rs67422857 | 6 | 135259753 | HBS1L | ENSG00000112339.10 | 6.384E-9 | 0 | 164441 | gtex_brain_putamen_basal |
| rs202230363 | 6 | 135259759 | HBS1L | ENSG00000112339.10 | 8.018E-9 | 0 | 164435 | gtex_brain_putamen_basal |
| rs4646871 | 6 | 135265617 | HBS1L | ENSG00000112339.10 | 8.018E-12 | 0 | 158577 | gtex_brain_putamen_basal |
| rs5012874 | 6 | 135267925 | HBS1L | ENSG00000112339.10 | 1.272E-6 | 0 | 156269 | gtex_brain_putamen_basal |
| rs7749106 | 6 | 135268142 | HBS1L | ENSG00000112339.10 | 1.546E-9 | 0 | 156052 | gtex_brain_putamen_basal |
| rs200182923 | 6 | 135268982 | HBS1L | ENSG00000112339.10 | 6.511E-9 | 0 | 155212 | gtex_brain_putamen_basal |
| rs4646868 | 6 | 135271946 | HBS1L | ENSG00000112339.10 | 1.206E-11 | 0 | 152248 | gtex_brain_putamen_basal |
| rs4646867 | 6 | 135272080 | HBS1L | ENSG00000112339.10 | 1.705E-6 | 0 | 152114 | gtex_brain_putamen_basal |
| rs4267967 | 6 | 135272477 | HBS1L | ENSG00000112339.10 | 1.91E-12 | 0 | 151717 | gtex_brain_putamen_basal |
| rs7771310 | 6 | 135272535 | HBS1L | ENSG00000112339.10 | 1.233E-6 | 0 | 151659 | gtex_brain_putamen_basal |
| rs71006746 | 6 | 135273396 | HBS1L | ENSG00000112339.10 | 1.452E-6 | 0 | 150798 | gtex_brain_putamen_basal |
| rs4472368 | 6 | 135274232 | HBS1L | ENSG00000112339.10 | 8.952E-11 | 0 | 149962 | gtex_brain_putamen_basal |
| rs4289677 | 6 | 135275485 | HBS1L | ENSG00000112339.10 | 3.76E-6 | 0 | 148709 | gtex_brain_putamen_basal |
| rs4440481 | 6 | 135276696 | HBS1L | ENSG00000112339.10 | 5.553E-12 | 0 | 147498 | gtex_brain_putamen_basal |
| rs4520025 | 6 | 135278619 | HBS1L | ENSG00000112339.10 | 3.446E-6 | 0 | 145575 | gtex_brain_putamen_basal |
| rs4451150 | 6 | 135279063 | HBS1L | ENSG00000112339.10 | 3.76E-6 | 0 | 145131 | gtex_brain_putamen_basal |
| rs9376072 | 6 | 135280519 | HBS1L | ENSG00000112339.10 | 1.196E-11 | 0 | 143675 | gtex_brain_putamen_basal |
| rs1135205 | 6 | 135281795 | HBS1L | ENSG00000112339.10 | 2.562E-11 | 0 | 142399 | gtex_brain_putamen_basal |
| rs9389248 | 6 | 135282656 | HBS1L | ENSG00000112339.10 | 1.375E-11 | 0 | 141538 | gtex_brain_putamen_basal |
| rs61738492 | 6 | 135282771 | HBS1L | ENSG00000112339.10 | 5.381E-7 | 0 | 141423 | gtex_brain_putamen_basal |
| rs4475342 | 6 | 135283348 | HBS1L | ENSG00000112339.10 | 2.232E-11 | 0 | 140846 | gtex_brain_putamen_basal |
| rs9399129 | 6 | 135285148 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 139046 | gtex_brain_putamen_basal |
| rs13199205 | 6 | 135286505 | HBS1L | ENSG00000112339.10 | 1.622E-11 | 0 | 137689 | gtex_brain_putamen_basal |
| rs4895434 | 6 | 135293365 | HBS1L | ENSG00000112339.10 | 4.743E-10 | 0 | 130829 | gtex_brain_putamen_basal |
| rs4896119 | 6 | 135293391 | HBS1L | ENSG00000112339.10 | 5.363E-12 | 0 | 130803 | gtex_brain_putamen_basal |
| rs4895435 | 6 | 135293463 | HBS1L | ENSG00000112339.10 | 4.735E-10 | 0 | 130731 | gtex_brain_putamen_basal |
| rs4896120 | 6 | 135293512 | HBS1L | ENSG00000112339.10 | 1.445E-10 | 0 | 130682 | gtex_brain_putamen_basal |
| rs4896121 | 6 | 135293645 | HBS1L | ENSG00000112339.10 | 5.59E-11 | 0 | 130549 | gtex_brain_putamen_basal |
| rs7755680 | 6 | 135294259 | HBS1L | ENSG00000112339.10 | 5.118E-12 | 0 | 129935 | gtex_brain_putamen_basal |
| rs4895436 | 6 | 135295001 | HBS1L | ENSG00000112339.10 | 5.118E-12 | 0 | 129193 | gtex_brain_putamen_basal |
| rs4896122 | 6 | 135295081 | HBS1L | ENSG00000112339.10 | 8.063E-12 | 0 | 129113 | gtex_brain_putamen_basal |
| rs4896123 | 6 | 135295410 | HBS1L | ENSG00000112339.10 | 4.53E-10 | 0 | 128784 | gtex_brain_putamen_basal |
| rs4407732 | 6 | 135296073 | HBS1L | ENSG00000112339.10 | 1.87E-11 | 0 | 128121 | gtex_brain_putamen_basal |
| rs9376075 | 6 | 135296963 | HBS1L | ENSG00000112339.10 | 5.118E-12 | 0 | 127231 | gtex_brain_putamen_basal |
| rs4273704 | 6 | 135297520 | HBS1L | ENSG00000112339.10 | 5.118E-12 | 0 | 126674 | gtex_brain_putamen_basal |
| rs4637662 | 6 | 135298158 | HBS1L | ENSG00000112339.10 | 5.118E-12 | 0 | 126036 | gtex_brain_putamen_basal |
| rs9376077 | 6 | 135299713 | HBS1L | ENSG00000112339.10 | 5.118E-12 | 0 | 124481 | gtex_brain_putamen_basal |
| rs35123050 | 6 | 135302740 | HBS1L | ENSG00000112339.10 | 1.416E-10 | 0 | 121454 | gtex_brain_putamen_basal |
| rs4376365 | 6 | 135307740 | HBS1L | ENSG00000112339.10 | 5.11E-12 | 0 | 116454 | gtex_brain_putamen_basal |
| rs4445070 | 6 | 135309212 | HBS1L | ENSG00000112339.10 | 1.657E-11 | 0 | 114982 | gtex_brain_putamen_basal |
| rs4388304 | 6 | 135309597 | HBS1L | ENSG00000112339.10 | 8.488E-12 | 0 | 114597 | gtex_brain_putamen_basal |
| rs13218642 | 6 | 135309940 | HBS1L | ENSG00000112339.10 | 5.439E-11 | 0 | 114254 | gtex_brain_putamen_basal |
| rs4451151 | 6 | 135310546 | HBS1L | ENSG00000112339.10 | 1.301E-11 | 0 | 113648 | gtex_brain_putamen_basal |
| rs11154790 | 6 | 135312945 | HBS1L | ENSG00000112339.10 | 3.31E-12 | 0 | 111249 | gtex_brain_putamen_basal |
| rs6925424 | 6 | 135313948 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 110246 | gtex_brain_putamen_basal |
| rs6902954 | 6 | 135313994 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 110200 | gtex_brain_putamen_basal |
| rs7741626 | 6 | 135314182 | HBS1L | ENSG00000112339.10 | 5.379E-12 | 0 | 110012 | gtex_brain_putamen_basal |
| rs6909975 | 6 | 135315570 | HBS1L | ENSG00000112339.10 | 1.423E-10 | 0 | 108624 | gtex_brain_putamen_basal |
| rs398085324 | 6 | 135316234 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 107960 | gtex_brain_putamen_basal |
| rs4895438 | 6 | 135317665 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 106529 | gtex_brain_putamen_basal |
| rs7773126 | 6 | 135318390 | HBS1L | ENSG00000112339.10 | 1.423E-10 | 0 | 105804 | gtex_brain_putamen_basal |
| rs4895439 | 6 | 135318854 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 105340 | gtex_brain_putamen_basal |
| rs397802384 | 6 | 135319562 | HBS1L | ENSG00000112339.10 | 3.381E-12 | 0 | 104632 | gtex_brain_putamen_basal |
| rs17638970 | 6 | 135320063 | HBS1L | ENSG00000112339.10 | 5.37E-11 | 0 | 104131 | gtex_brain_putamen_basal |
| rs11754504 | 6 | 135321509 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 102685 | gtex_brain_putamen_basal |
| rs9402673 | 6 | 135322620 | HBS1L | ENSG00000112339.10 | 3.462E-10 | 0 | 101574 | gtex_brain_putamen_basal |
| rs9688342 | 6 | 135323026 | HBS1L | ENSG00000112339.10 | 3.046E-10 | 0 | 101168 | gtex_brain_putamen_basal |
| rs74279965 | 6 | 135323203 | HBS1L | ENSG00000112339.10 | 9.171E-10 | 0 | 100991 | gtex_brain_putamen_basal |
| rs199731039 | 6 | 135324050 | HBS1L | ENSG00000112339.10 | 3.419E-11 | 0 | 100144 | gtex_brain_putamen_basal |
| rs78074109 | 6 | 135324052 | HBS1L | ENSG00000112339.10 | 4.479E-11 | 0 | 100142 | gtex_brain_putamen_basal |
| rs4559100 | 6 | 135324085 | HBS1L | ENSG00000112339.10 | 5.355E-11 | 0 | 100109 | gtex_brain_putamen_basal |
| rs12527707 | 6 | 135324511 | HBS1L | ENSG00000112339.10 | 4.578E-11 | 0 | 99683 | gtex_brain_putamen_basal |
| rs12527683 | 6 | 135324534 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 99660 | gtex_brain_putamen_basal |
| rs9389251 | 6 | 135325717 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 98477 | gtex_brain_putamen_basal |
| rs9402675 | 6 | 135325794 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 98400 | gtex_brain_putamen_basal |
| rs12526055 | 6 | 135325918 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 98276 | gtex_brain_putamen_basal |
| rs6929661 | 6 | 135328792 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 95402 | gtex_brain_putamen_basal |
| rs9389253 | 6 | 135329755 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 94439 | gtex_brain_putamen_basal |
| rs2327578 | 6 | 135329969 | HBS1L | ENSG00000112339.10 | 6.402E-11 | 0 | 94225 | gtex_brain_putamen_basal |
| rs9389254 | 6 | 135330709 | HBS1L | ENSG00000112339.10 | 2.659E-11 | 0 | 93485 | gtex_brain_putamen_basal |
| rs9389255 | 6 | 135330873 | HBS1L | ENSG00000112339.10 | 1.032E-9 | 0 | 93321 | gtex_brain_putamen_basal |
| rs9389256 | 6 | 135331254 | HBS1L | ENSG00000112339.10 | 9.431E-12 | 0 | 92940 | gtex_brain_putamen_basal |
| rs6910530 | 6 | 135332770 | HBS1L | ENSG00000112339.10 | 1.127E-8 | 0 | 91424 | gtex_brain_putamen_basal |
| rs1014020 | 6 | 135334426 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 89768 | gtex_brain_putamen_basal |
| rs1014021 | 6 | 135334600 | HBS1L | ENSG00000112339.10 | 1.625E-11 | 0 | 89594 | gtex_brain_putamen_basal |
| rs1041481 | 6 | 135335063 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 89131 | gtex_brain_putamen_basal |
| rs6923765 | 6 | 135335176 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 89018 | gtex_brain_putamen_basal |
| rs6923827 | 6 | 135335382 | HBS1L | ENSG00000112339.10 | 3.251E-10 | 0 | 88812 | gtex_brain_putamen_basal |
| rs6902438 | 6 | 135336587 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 87607 | gtex_brain_putamen_basal |
| rs6902888 | 6 | 135336857 | HBS1L | ENSG00000112339.10 | 5.351E-11 | 0 | 87337 | gtex_brain_putamen_basal |
| rs9385713 | 6 | 135337039 | HBS1L | ENSG00000112339.10 | 1.113E-8 | 0 | 87155 | gtex_brain_putamen_basal |
| rs6908681 | 6 | 135337733 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 86461 | gtex_brain_putamen_basal |
| rs386408702 | 6 | 135338053 | HBS1L | ENSG00000112339.10 | 4.135E-12 | 0 | 86141 | gtex_brain_putamen_basal |
| rs200605623 | 6 | 135339133 | HBS1L | ENSG00000112339.10 | 3.26E-11 | 0 | 85061 | gtex_brain_putamen_basal |
| rs3756799 | 6 | 135341011 | HBS1L | ENSG00000112339.10 | 5.292E-12 | 0 | 83183 | gtex_brain_putamen_basal |
| rs59329760 | 6 | 135342437 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 81757 | gtex_brain_putamen_basal |
| rs4896125 | 6 | 135342569 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 81625 | gtex_brain_putamen_basal |
| rs4896126 | 6 | 135342786 | HBS1L | ENSG00000112339.10 | 4.975E-12 | 0 | 81408 | gtex_brain_putamen_basal |
| rs978036 | 6 | 135342903 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 81291 | gtex_brain_putamen_basal |
| rs949547 | 6 | 135343499 | HBS1L | ENSG00000112339.10 | 6.8E-11 | 0 | 80695 | gtex_brain_putamen_basal |
| rs1023179 | 6 | 135343829 | HBS1L | ENSG00000112339.10 | 2.931E-12 | 0 | 80365 | gtex_brain_putamen_basal |
| rs9389257 | 6 | 135344311 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 79883 | gtex_brain_putamen_basal |
| rs9376082 | 6 | 135346389 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 77805 | gtex_brain_putamen_basal |
| rs397701688 | 6 | 135346639 | HBS1L | ENSG00000112339.10 | 3.239E-10 | 0 | 77555 | gtex_brain_putamen_basal |
| rs2150680 | 6 | 135347131 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 77063 | gtex_brain_putamen_basal |
| rs11756988 | 6 | 135347595 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 76599 | gtex_brain_putamen_basal |
| rs11754783 | 6 | 135347661 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 76533 | gtex_brain_putamen_basal |
| rs952674 | 6 | 135349157 | HBS1L | ENSG00000112339.10 | 7.47E-12 | 0 | 75037 | gtex_brain_putamen_basal |
| rs12661423 | 6 | 135349570 | HBS1L | ENSG00000112339.10 | 5.024E-11 | 0 | 74624 | gtex_brain_putamen_basal |
| rs987690 | 6 | 135350379 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 73815 | gtex_brain_putamen_basal |
| rs397716890 | 6 | 135350485 | HBS1L | ENSG00000112339.10 | 5.882E-12 | 0 | 73709 | gtex_brain_putamen_basal |
| rs7750300 | 6 | 135350950 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 73244 | gtex_brain_putamen_basal |
| rs1590975 | 6 | 135352088 | HBS1L | ENSG00000112339.10 | 2.543E-11 | 0 | 72106 | gtex_brain_putamen_basal |
| rs6569988 | 6 | 135352303 | HBS1L | ENSG00000112339.10 | 3.251E-10 | 0 | 71891 | gtex_brain_putamen_basal |
| rs6919862 | 6 | 135352443 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 71751 | gtex_brain_putamen_basal |
| rs9321481 | 6 | 135352648 | HBS1L | ENSG00000112339.10 | 5.019E-12 | 0 | 71546 | gtex_brain_putamen_basal |
| rs10872427 | 6 | 135353452 | HBS1L | ENSG00000112339.10 | 5.341E-11 | 0 | 70742 | gtex_brain_putamen_basal |
| rs7766189 | 6 | 135353851 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 70343 | gtex_brain_putamen_basal |
| rs74279966 | 6 | 135354072 | HBS1L | ENSG00000112339.10 | 4.147E-11 | 0 | 70122 | gtex_brain_putamen_basal |
| rs4134030 | 6 | 135354094 | HBS1L | ENSG00000112339.10 | 4.836E-9 | 0 | 70100 | gtex_brain_putamen_basal |
| rs4896130 | 6 | 135355118 | HBS1L | ENSG00000112339.10 | 4.449E-10 | 0 | 69076 | gtex_brain_putamen_basal |
| rs9402676 | 6 | 135355507 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 68687 | gtex_brain_putamen_basal |
| rs7748274 | 6 | 135355723 | HBS1L | ENSG00000112339.10 | 1.625E-11 | 0 | 68471 | gtex_brain_putamen_basal |
| rs11754265 | 6 | 135356216 | HBS1L | ENSG00000112339.10 | 3.251E-10 | 0 | 67978 | gtex_brain_putamen_basal |
| rs7742542 | 6 | 135358567 | HBS1L | ENSG00000112339.10 | 5.369E-11 | 0 | 65627 | gtex_brain_putamen_basal |
| rs61459569 | 6 | 135359508 | HBS1L | ENSG00000112339.10 | 8.351E-11 | 0 | 64686 | gtex_brain_putamen_basal |
| rs1854865 | 6 | 135360300 | HBS1L | ENSG00000112339.10 | 1.557E-11 | 0 | 63894 | gtex_brain_putamen_basal |
| rs9389258 | 6 | 135361140 | HBS1L | ENSG00000112339.10 | 5.349E-11 | 0 | 63054 | gtex_brain_putamen_basal |
| rs7763836 | 6 | 135362378 | HBS1L | ENSG00000112339.10 | 2.131E-10 | 0 | 61816 | gtex_brain_putamen_basal |
| rs2327580 | 6 | 135364417 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 59777 | gtex_brain_putamen_basal |
| rs6569990 | 6 | 135365818 | HBS1L | ENSG00000112339.10 | 1.094E-10 | 0 | 58376 | gtex_brain_putamen_basal |
| rs13191501 | 6 | 135366880 | HBS1L | ENSG00000112339.10 | 2.913E-11 | 0 | 57314 | gtex_brain_putamen_basal |
| rs398085326 | 6 | 135367389 | HBS1L | ENSG00000112339.10 | 5.225E-11 | 0 | 56805 | gtex_brain_putamen_basal |
| rs6908512 | 6 | 135367757 | HBS1L | ENSG00000112339.10 | 3.326E-11 | 0 | 56437 | gtex_brain_putamen_basal |
| rs13209789 | 6 | 135367916 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 56278 | gtex_brain_putamen_basal |
| rs9399135 | 6 | 135368314 | HBS1L | ENSG00000112339.10 | 4.449E-10 | 0 | 55880 | gtex_brain_putamen_basal |
| rs6915770 | 6 | 135369214 | HBS1L | ENSG00000112339.10 | 5.345E-11 | 0 | 54980 | gtex_brain_putamen_basal |
| rs34546690 | 6 | 135369709 | HBS1L | ENSG00000112339.10 | 2.131E-10 | 0 | 54485 | gtex_brain_putamen_basal |
| rs11755229 | 6 | 135369913 | HBS1L | ENSG00000112339.10 | 3.326E-11 | 0 | 54281 | gtex_brain_putamen_basal |
| rs11759999 | 6 | 135370495 | HBS1L | ENSG00000112339.10 | 2.677E-11 | 0 | 53699 | gtex_brain_putamen_basal |
| rs11760000 | 6 | 135370496 | HBS1L | ENSG00000112339.10 | 4.229E-11 | 0 | 53698 | gtex_brain_putamen_basal |
| rs9402677 | 6 | 135370708 | HBS1L | ENSG00000112339.10 | 2.427E-11 | 0 | 53486 | gtex_brain_putamen_basal |
| rs9389261 | 6 | 135371148 | HBS1L | ENSG00000112339.10 | 3.407E-11 | 0 | 53046 | gtex_brain_putamen_basal |
| rs9376085 | 6 | 135371224 | HBS1L | ENSG00000112339.10 | 2.352E-11 | 0 | 52970 | gtex_brain_putamen_basal |
| rs9376086 | 6 | 135371329 | HBS1L | ENSG00000112339.10 | 5.503E-11 | 0 | 52865 | gtex_brain_putamen_basal |
| rs9402678 | 6 | 135372103 | HBS1L | ENSG00000112339.10 | 5.503E-11 | 0 | 52091 | gtex_brain_putamen_basal |
| rs9376087 | 6 | 135372231 | HBS1L | ENSG00000112339.10 | 3.75E-9 | 0 | 51963 | gtex_brain_putamen_basal |
| rs1041480 | 6 | 135373076 | HBS1L | ENSG00000112339.10 | 5.503E-11 | 0 | 51118 | gtex_brain_putamen_basal |
| rs9373122 | 6 | 135373534 | HBS1L | ENSG00000112339.10 | 2.178E-10 | 0 | 50660 | gtex_brain_putamen_basal |
| rs7741515 | 6 | 135374368 | HBS1L | ENSG00000112339.10 | 5.503E-11 | 0 | 49826 | gtex_brain_putamen_basal |
| rs2150681 | 6 | 135375232 | HBS1L | ENSG00000112339.10 | 1.925E-10 | 0 | 48962 | gtex_brain_putamen_basal |
| rs2297338 | 6 | 135375762 | HBS1L | ENSG00000112339.10 | 2.639E-11 | 0 | 48432 | gtex_brain_putamen_basal |
| rs2297339 | 6 | 135375991 | HBS1L | ENSG00000112339.10 | 1.031E-11 | 0 | 48203 | gtex_brain_putamen_basal |
| rs2297340 | 6 | 135376058 | HBS1L | ENSG00000112339.10 | 5.503E-11 | 0 | 48136 | gtex_brain_putamen_basal |
| rs28384512 | 6 | 135376232 | HBS1L | ENSG00000112339.10 | 6.769E-11 | 0 | 47962 | gtex_brain_putamen_basal |
| rs41294852 | 6 | 135376379 | HBS1L | ENSG00000112339.10 | 1.921E-10 | 0 | 47815 | gtex_brain_putamen_basal |
| rs9389262 | 6 | 135376409 | HBS1L | ENSG00000112339.10 | 2.634E-11 | 0 | 47785 | gtex_brain_putamen_basal |
| rs2183709 | 6 | 135377091 | HBS1L | ENSG00000112339.10 | 2.629E-11 | 0 | 47103 | gtex_brain_putamen_basal |
| rs4142299 | 6 | 135377186 | HBS1L | ENSG00000112339.10 | 2.629E-11 | 0 | 47008 | gtex_brain_putamen_basal |
| rs2150682 | 6 | 135377632 | HBS1L | ENSG00000112339.10 | 5.484E-11 | 0 | 46562 | gtex_brain_putamen_basal |
| rs397796924 | 6 | 135378253 | HBS1L | ENSG00000112339.10 | 2.074E-10 | 0 | 45941 | gtex_brain_putamen_basal |
| rs200769099 | 6 | 135383222 | HBS1L | ENSG00000112339.10 | 7.508E-7 | 0 | 40972 | gtex_brain_putamen_basal |
| rs11757577 | 6 | 135391465 | HBS1L | ENSG00000112339.10 | 5.865E-9 | 0 | 32729 | gtex_brain_putamen_basal |
| rs4896131 | 6 | 135392100 | HBS1L | ENSG00000112339.10 | 7.274E-9 | 0 | 32094 | gtex_brain_putamen_basal |
| rs9402681 | 6 | 135397301 | HBS1L | ENSG00000112339.10 | 1.5E-6 | 0 | 26893 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0003746 | translation elongation factor activity | IEA | - | |
| GO:0003924 | GTPase activity | IEA | - | |
| GO:0005525 | GTP binding | IEA | - | |
| GO:0005525 | GTP binding | TAS | 9872408 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006412 | translation | TAS | 9872408 | |
| GO:0007165 | signal transduction | TAS | 9872408 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| HOLLMANN APOPTOSIS VIA CD40 UP | 201 | 125 | All SZGR 2.0 genes in this pathway |
| SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP | 408 | 247 | All SZGR 2.0 genes in this pathway |
| WILCOX RESPONSE TO PROGESTERONE UP | 152 | 90 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN | 320 | 184 | All SZGR 2.0 genes in this pathway |
| WANG CLIM2 TARGETS DN | 186 | 114 | All SZGR 2.0 genes in this pathway |
| ODONNELL TFRC TARGETS UP | 456 | 228 | All SZGR 2.0 genes in this pathway |
| BIDUS METASTASIS UP | 214 | 134 | All SZGR 2.0 genes in this pathway |
| DARWICHE SKIN TUMOR PROMOTER UP | 142 | 96 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA RISK LOW UP | 162 | 104 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA RISK HIGH UP | 147 | 101 | All SZGR 2.0 genes in this pathway |
| DARWICHE SQUAMOUS CELL CARCINOMA UP | 146 | 104 | All SZGR 2.0 genes in this pathway |
| FRIDMAN SENESCENCE UP | 77 | 60 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| ZHENG BOUND BY FOXP3 | 491 | 310 | All SZGR 2.0 genes in this pathway |
| ZHENG FOXP3 TARGETS IN THYMUS UP | 196 | 137 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS UP | 673 | 430 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS UP | 602 | 364 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS UP | 601 | 369 | All SZGR 2.0 genes in this pathway |
| BOCHKIS FOXA2 TARGETS | 425 | 261 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER DN | 238 | 145 | All SZGR 2.0 genes in this pathway |
| HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE DN | 50 | 36 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | 456 | 285 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 AND SATB1 UP | 87 | 52 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
| miRNA family | Target position | miRNA ID | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| miR-200bc/429 | 148 | 154 | 1A | hsa-miR-200b | UAAUACUGCCUGGUAAUGAUGAC |
| hsa-miR-200c | UAAUACUGCCGGGUAAUGAUGG | ||||
| hsa-miR-429 | UAAUACUGUCUGGUAAAACCGU | ||||
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.