Gene Page: STARD3
Summary ?
| GeneID | 10948 |
| Symbol | STARD3 |
| Synonyms | CAB1|MLN64|es64 |
| Description | StAR related lipid transfer domain containing 3 |
| Reference | MIM:607048|HGNC:HGNC:17579|HPRD:06132| |
| Gene type | protein-coding |
| Map location | 17q11-q12 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.856 |
| Fetal beta | -0.187 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg20669414 | 17 | 37808629 | STARD3 | 2.299E-4 | -0.611 | 0.036 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C4orf18 | 0.76 | 0.75 |
| ADAM9 | 0.76 | 0.77 |
| MPP5 | 0.75 | 0.78 |
| TOR1AIP1 | 0.74 | 0.75 |
| PCGF5 | 0.72 | 0.76 |
| RASSF8 | 0.72 | 0.73 |
| USP8 | 0.71 | 0.71 |
| CD164 | 0.71 | 0.72 |
| SPTLC1 | 0.70 | 0.73 |
| STK38L | 0.70 | 0.69 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| WDR86 | -0.39 | -0.39 |
| SH2D2A | -0.38 | -0.42 |
| SIGIRR | -0.38 | -0.44 |
| SH2B2 | -0.36 | -0.38 |
| RPL28 | -0.33 | -0.44 |
| NEUROD2 | -0.33 | -0.13 |
| TMEM108 | -0.33 | -0.11 |
| EIF4EBP1 | -0.33 | -0.36 |
| AP003068.3 | -0.32 | -0.38 |
| SH3BP2 | -0.32 | -0.34 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0008289 | lipid binding | IEA | - | |
| GO:0017127 | cholesterol transporter activity | IEA | - | |
| GO:0015485 | cholesterol binding | IDA | 12011453 | |
| GO:0015485 | cholesterol binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006839 | mitochondrial transport | TAS | glutamate (GO term level: 6) | 9270027 |
| GO:0008203 | cholesterol metabolic process | TAS | 9270027 | |
| GO:0006700 | C21-steroid hormone biosynthetic process | IEA | - | |
| GO:0006694 | steroid biosynthetic process | IEA | - | |
| GO:0006629 | lipid metabolic process | TAS | 7490069 | |
| GO:0006869 | lipid transport | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | cytoplasm | TAS | 9139840 | |
| GO:0005768 | endosome | IEA | - | |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0031902 | late endosome membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON | 133 | 78 | All SZGR 2.0 genes in this pathway |
| SHEPARD BMYB MORPHOLINO UP | 205 | 126 | All SZGR 2.0 genes in this pathway |
| ASTIER INTEGRIN SIGNALING | 59 | 44 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 20HR UP | 240 | 152 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 16HR UP | 225 | 139 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| LEE CALORIE RESTRICTION MUSCLE DN | 51 | 28 | All SZGR 2.0 genes in this pathway |
| HELLER HDAC TARGETS UP | 317 | 208 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 2D UP | 69 | 46 | All SZGR 2.0 genes in this pathway |
| AMBROSINI FLAVOPIRIDOL TREATMENT TP53 | 109 | 63 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER ERBB2 UP | 147 | 83 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| MOOTHA HUMAN MITODB 6 2002 | 429 | 260 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| SENGUPTA EBNA1 ANTICORRELATED | 173 | 85 | All SZGR 2.0 genes in this pathway |