Gene Page: CHRNA7

Summary ?
GeneID1139
SymbolCHRNA7
SynonymsCHRNA7-2|NACHRA7
Descriptioncholinergic receptor nicotinic alpha 7 subunit
ReferenceMIM:118511|HGNC:HGNC:1960|Ensembl:ENSG00000175344|HPRD:00339|Vega:OTTHUMG00000129285
Gene typeprotein-coding
Map location15q14
Pascal p-value0.133
Fetal beta0.528
SupportLIGAND GATED ION SIGNALING

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CNV:YESCopy number variation studiesManual curation
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KIAA01960.870.85
TRIP120.870.87
MTMR150.860.86
IPO80.860.85
KIAA10120.850.86
FAM178A0.850.86
NBR10.850.84
PTK20.850.83
UTP14C0.840.86
RBBP50.840.85
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.67-0.64
IFI27-0.64-0.67
IL32-0.62-0.61
MT-CO2-0.62-0.62
FXYD1-0.61-0.63
HIGD1B-0.60-0.63
VAMP5-0.60-0.60
AF347015.31-0.59-0.62
CXCL14-0.59-0.63
CSAG1-0.59-0.59

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0030594neurotransmitter receptor activityIEANeurotransmitter (GO term level: 5)-
GO:0015464acetylcholine receptor activityIDANeurotransmitter (GO term level: 6)8906617 
GO:0001540beta-amyloid bindingIPI10681545 
GO:0004889nicotinic acetylcholine-activated cation-selective channel activityIDA8145738 |8906617 
GO:0004889nicotinic acetylcholine-activated cation-selective channel activityIEA-
GO:0005515protein bindingIEA-
GO:0005216ion channel activityIEA-
GO:0005230extracellular ligand-gated ion channel activityIEA-
GO:0015643toxin bindingIDA12508119 
GO:0017081chloride channel regulator activityIDA8145738 
GO:0042803protein homodimerization activityIDA8145738 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007271synaptic transmission, cholinergicIEAneuron, Cholinergic, Synap, Neurotransmitter (GO term level: 7)-
GO:0032225regulation of synaptic transmission, dopaminergicIEAneuron, Synap, Neurotransmitter, dopamine (GO term level: 9)-
GO:0000187activation of MAPK activityIDA10771023 
GO:0001666response to hypoxiaIDA12189247 
GO:0001988positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressureIEA-
GO:0007165signal transductionIDA8906617 
GO:0008284positive regulation of cell proliferationIMP16280133 |17498763 
GO:0008306associative learningIEA-
GO:0007613memoryIEA-
GO:0007613memoryNAS10681545 
GO:0006816calcium ion transportIDA8145738 
GO:0006816calcium ion transportIMP10771023 
GO:0006811ion transportIEA-
GO:0006811ion transportNAS8906617 
GO:0006897endocytosisIEA-
GO:0006874cellular calcium ion homeostasisIMP16280133 
GO:0014061regulation of norepinephrine secretionIEA-
GO:0042391regulation of membrane potentialIEA-
GO:0032094response to foodIEA-
GO:0042698ovulation cycleIEA-
GO:0042113B cell activationIEA-
GO:0042110T cell activationIEA-
GO:0032720negative regulation of tumor necrosis factor productionIEA-
GO:0032720negative regulation of tumor necrosis factor productionIMP12508119 
GO:0032715negative regulation of interleukin-6 productionIEA-
GO:0032691negative regulation of interleukin-1 beta productionIEA-
GO:0030317sperm motilityIEA-
GO:0035095behavioral response to nicotineIEA-
GO:0045766positive regulation of angiogenesisIMP12189247 |16280133 
GO:0048149behavioral response to ethanolIEA-
GO:0050728negative regulation of inflammatory responseIDA12508119 
GO:0050728negative regulation of inflammatory responseIEA-
GO:0060112generation of ovulation cycle rhythmIEA-
GO:0050890cognitionIMP16754836 
GO:0050890cognitionNAS10681545 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005892nicotinic acetylcholine-gated receptor-channel complexIDANeurotransmitter (GO term level: 9)8906617 
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005624membrane fractionIEA-
GO:0016021integral to membraneIEA-
GO:0016021integral to membraneNAS8145738 |8906617 
GO:0009897external side of plasma membraneIEA-
GO:0005886plasma membraneIDA16280133 
GO:0016324apical plasma membraneIEA-
GO:0030054cell junctionIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137110All SZGR 2.0 genes in this pathway
REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 1613All SZGR 2.0 genes in this pathway
REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 1312All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203134All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA RADIATION 8159All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226164All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS DN 9753All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL DN 214124All SZGR 2.0 genes in this pathway