Gene Page: CLDN4
Summary ?
| GeneID | 1364 |
| Symbol | CLDN4 |
| Synonyms | CPE-R|CPER|CPETR|CPETR1|WBSCR8|hCPE-R |
| Description | claudin 4 |
| Reference | MIM:602909|HGNC:HGNC:2046|Ensembl:ENSG00000189143|HPRD:04218| |
| Gene type | protein-coding |
| Map location | 7q11.23 |
| Pascal p-value | 0.686 |
| Fetal beta | -0.185 |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Frontal Cortex BA9 Nucleus accumbens basal ganglia Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CNV:YES | Copy number variation studies | Manual curation | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7777704 | 7 | 73210977 | CLDN4 | ENSG00000189143.8 | 4.999E-6 | 0 | -2895 | gtex_brain_putamen_basal |
| rs28414777 | 7 | 73212647 | CLDN4 | ENSG00000189143.8 | 6.426E-6 | 0 | -1225 | gtex_brain_putamen_basal |
| rs12537291 | 7 | 73212929 | CLDN4 | ENSG00000189143.8 | 6.3E-6 | 0 | -943 | gtex_brain_putamen_basal |
| rs4632942 | 7 | 73213712 | CLDN4 | ENSG00000189143.8 | 5.921E-6 | 0 | -160 | gtex_brain_putamen_basal |
| rs10223902 | 7 | 73214382 | CLDN4 | ENSG00000189143.8 | 5.613E-6 | 0 | 510 | gtex_brain_putamen_basal |
| rs12668451 | 7 | 73214999 | CLDN4 | ENSG00000189143.8 | 2.132E-6 | 0 | 1127 | gtex_brain_putamen_basal |
| rs10949828 | 7 | 73216733 | CLDN4 | ENSG00000189143.8 | 1.855E-6 | 0 | 2861 | gtex_brain_putamen_basal |
| rs150887167 | 7 | 73220024 | CLDN4 | ENSG00000189143.8 | 2.381E-6 | 0 | 6152 | gtex_brain_putamen_basal |
| rs7796554 | 7 | 73220040 | CLDN4 | ENSG00000189143.8 | 2.698E-6 | 0 | 6168 | gtex_brain_putamen_basal |
| rs6460060 | 7 | 73221042 | CLDN4 | ENSG00000189143.8 | 1.237E-6 | 0 | 7170 | gtex_brain_putamen_basal |
| rs35558014 | 7 | 73223077 | CLDN4 | ENSG00000189143.8 | 8.271E-7 | 0 | 9205 | gtex_brain_putamen_basal |
| rs7812097 | 7 | 73223473 | CLDN4 | ENSG00000189143.8 | 1.096E-6 | 0 | 9601 | gtex_brain_putamen_basal |
| rs4355658 | 7 | 73225692 | CLDN4 | ENSG00000189143.8 | 1.017E-6 | 0 | 11820 | gtex_brain_putamen_basal |
| rs7804571 | 7 | 73233877 | CLDN4 | ENSG00000189143.8 | 2.01E-6 | 0 | 20005 | gtex_brain_putamen_basal |
| rs4717820 | 7 | 73236266 | CLDN4 | ENSG00000189143.8 | 6.423E-7 | 0 | 22394 | gtex_brain_putamen_basal |
| rs13223112 | 7 | 73236508 | CLDN4 | ENSG00000189143.8 | 1.773E-6 | 0 | 22636 | gtex_brain_putamen_basal |
| rs6946037 | 7 | 73236715 | CLDN4 | ENSG00000189143.8 | 1.655E-6 | 0 | 22843 | gtex_brain_putamen_basal |
| rs13234080 | 7 | 73237631 | CLDN4 | ENSG00000189143.8 | 6.469E-7 | 0 | 23759 | gtex_brain_putamen_basal |
| rs7798477 | 7 | 73238330 | CLDN4 | ENSG00000189143.8 | 6.483E-7 | 0 | 24458 | gtex_brain_putamen_basal |
| rs7798641 | 7 | 73238428 | CLDN4 | ENSG00000189143.8 | 6.487E-7 | 0 | 24556 | gtex_brain_putamen_basal |
| rs13228435 | 7 | 73239172 | CLDN4 | ENSG00000189143.8 | 6.5E-7 | 0 | 25300 | gtex_brain_putamen_basal |
| rs4255023 | 7 | 73239618 | CLDN4 | ENSG00000189143.8 | 1.684E-6 | 0 | 25746 | gtex_brain_putamen_basal |
| rs7808268 | 7 | 73240171 | CLDN4 | ENSG00000189143.8 | 6.369E-7 | 0 | 26299 | gtex_brain_putamen_basal |
| rs7808585 | 7 | 73240296 | CLDN4 | ENSG00000189143.8 | 1.641E-6 | 0 | 26424 | gtex_brain_putamen_basal |
| rs4717109 | 7 | 73240991 | CLDN4 | ENSG00000189143.8 | 6.172E-7 | 0 | 27119 | gtex_brain_putamen_basal |
| rs4717821 | 7 | 73240993 | CLDN4 | ENSG00000189143.8 | 1.6E-6 | 0 | 27121 | gtex_brain_putamen_basal |
| rs7455225 | 7 | 73241386 | CLDN4 | ENSG00000189143.8 | 2.377E-6 | 0 | 27514 | gtex_brain_putamen_basal |
| rs6974182 | 7 | 73242977 | CLDN4 | ENSG00000189143.8 | 5.847E-7 | 0 | 29105 | gtex_brain_putamen_basal |
| rs6974378 | 7 | 73243139 | CLDN4 | ENSG00000189143.8 | 5.818E-7 | 0 | 29267 | gtex_brain_putamen_basal |
| rs4717822 | 7 | 73243786 | CLDN4 | ENSG00000189143.8 | 3.021E-7 | 0 | 29914 | gtex_brain_putamen_basal |
| rs7793169 | 7 | 73244214 | CLDN4 | ENSG00000189143.8 | 5.146E-7 | 0 | 30342 | gtex_brain_putamen_basal |
| rs7793313 | 7 | 73244282 | CLDN4 | ENSG00000189143.8 | 1.322E-6 | 0 | 30410 | gtex_brain_putamen_basal |
| rs4304220 | 7 | 73244761 | CLDN4 | ENSG00000189143.8 | 1.192E-6 | 0 | 30889 | gtex_brain_putamen_basal |
| rs4640941 | 7 | 73245103 | CLDN4 | ENSG00000189143.8 | 1.117E-6 | 0 | 31231 | gtex_brain_putamen_basal |
| rs4458741 | 7 | 73245179 | CLDN4 | ENSG00000189143.8 | 4.14E-7 | 0 | 31307 | gtex_brain_putamen_basal |
| rs8629 | 7 | 73245519 | CLDN4 | ENSG00000189143.8 | 3.365E-7 | 0 | 31647 | gtex_brain_putamen_basal |
| rs1127155 | 7 | 73246461 | CLDN4 | ENSG00000189143.8 | 5.145E-7 | 0 | 32589 | gtex_brain_putamen_basal |
| rs1127156 | 7 | 73246496 | CLDN4 | ENSG00000189143.8 | 3.365E-7 | 0 | 32624 | gtex_brain_putamen_basal |
| rs11316 | 7 | 73246555 | CLDN4 | ENSG00000189143.8 | 8.911E-7 | 0 | 32683 | gtex_brain_putamen_basal |
| rs9691413 | 7 | 73247204 | CLDN4 | ENSG00000189143.8 | 3.365E-7 | 0 | 33332 | gtex_brain_putamen_basal |
| rs6968360 | 7 | 73247732 | CLDN4 | ENSG00000189143.8 | 5.145E-7 | 0 | 33860 | gtex_brain_putamen_basal |
| rs7786850 | 7 | 73248572 | CLDN4 | ENSG00000189143.8 | 3.504E-7 | 0 | 34700 | gtex_brain_putamen_basal |
| rs4286826 | 7 | 73248586 | CLDN4 | ENSG00000189143.8 | 3.455E-7 | 0 | 34714 | gtex_brain_putamen_basal |
| rs4473910 | 7 | 73248662 | CLDN4 | ENSG00000189143.8 | 3.365E-7 | 0 | 34790 | gtex_brain_putamen_basal |
| rs13246460 | 7 | 73249165 | CLDN4 | ENSG00000189143.8 | 3.365E-7 | 0 | 35293 | gtex_brain_putamen_basal |
| rs13232463 | 7 | 73249299 | CLDN4 | ENSG00000189143.8 | 3.365E-7 | 0 | 35427 | gtex_brain_putamen_basal |
| rs1989670 | 7 | 73251919 | CLDN4 | ENSG00000189143.8 | 4.047E-7 | 0 | 38047 | gtex_brain_putamen_basal |
| rs4484569 | 7 | 73252900 | CLDN4 | ENSG00000189143.8 | 3.365E-7 | 0 | 39028 | gtex_brain_putamen_basal |
| rs4304218 | 7 | 73252980 | CLDN4 | ENSG00000189143.8 | 8.911E-7 | 0 | 39108 | gtex_brain_putamen_basal |
| rs7811711 | 7 | 73253100 | CLDN4 | ENSG00000189143.8 | 3.365E-7 | 0 | 39228 | gtex_brain_putamen_basal |
| rs7811317 | 7 | 73253107 | CLDN4 | ENSG00000189143.8 | 3.365E-7 | 0 | 39235 | gtex_brain_putamen_basal |
| rs13247441 | 7 | 73253143 | CLDN4 | ENSG00000189143.8 | 3.365E-7 | 0 | 39271 | gtex_brain_putamen_basal |
| rs10282443 | 7 | 73253243 | CLDN4 | ENSG00000189143.8 | 3.365E-7 | 0 | 39371 | gtex_brain_putamen_basal |
| rs10252756 | 7 | 73253270 | CLDN4 | ENSG00000189143.8 | 5.145E-7 | 0 | 39398 | gtex_brain_putamen_basal |
| rs13223593 | 7 | 73253772 | CLDN4 | ENSG00000189143.8 | 3.365E-7 | 0 | 39900 | gtex_brain_putamen_basal |
| rs13241921 | 7 | 73254812 | CLDN4 | ENSG00000189143.8 | 3.279E-7 | 0 | 40940 | gtex_brain_putamen_basal |
| rs13242043 | 7 | 73254910 | CLDN4 | ENSG00000189143.8 | 8.874E-7 | 0 | 41038 | gtex_brain_putamen_basal |
| rs4333464 | 7 | 73255165 | CLDN4 | ENSG00000189143.8 | 3.247E-7 | 0 | 41293 | gtex_brain_putamen_basal |
| rs4314544 | 7 | 73255252 | CLDN4 | ENSG00000189143.8 | 3.236E-7 | 0 | 41380 | gtex_brain_putamen_basal |
| rs4717823 | 7 | 73255647 | CLDN4 | ENSG00000189143.8 | 8.908E-7 | 0 | 41775 | gtex_brain_putamen_basal |
| rs10276377 | 7 | 73256838 | CLDN4 | ENSG00000189143.8 | 3.107E-7 | 0 | 42966 | gtex_brain_putamen_basal |
| rs10233067 | 7 | 73256920 | CLDN4 | ENSG00000189143.8 | 3.107E-7 | 0 | 43048 | gtex_brain_putamen_basal |
| rs7809965 | 7 | 73257901 | CLDN4 | ENSG00000189143.8 | 3.057E-7 | 0 | 44029 | gtex_brain_putamen_basal |
| rs201658367 | 7 | 73258086 | CLDN4 | ENSG00000189143.8 | 1.474E-7 | 0 | 44214 | gtex_brain_putamen_basal |
| rs11763367 | 7 | 73258087 | CLDN4 | ENSG00000189143.8 | 1.507E-7 | 0 | 44215 | gtex_brain_putamen_basal |
| rs1073909 | 7 | 73258289 | CLDN4 | ENSG00000189143.8 | 3.968E-7 | 0 | 44417 | gtex_brain_putamen_basal |
| rs10225983 | 7 | 73258750 | CLDN4 | ENSG00000189143.8 | 2.785E-7 | 0 | 44878 | gtex_brain_putamen_basal |
| rs4301345 | 7 | 73259935 | CLDN4 | ENSG00000189143.8 | 3.01E-7 | 0 | 46063 | gtex_brain_putamen_basal |
| rs9647786 | 7 | 73260670 | CLDN4 | ENSG00000189143.8 | 8.934E-7 | 0 | 46798 | gtex_brain_putamen_basal |
| rs10234724 | 7 | 73261247 | CLDN4 | ENSG00000189143.8 | 2.944E-7 | 0 | 47375 | gtex_brain_putamen_basal |
| rs13221434 | 7 | 73261817 | CLDN4 | ENSG00000189143.8 | 5.567E-7 | 0 | 47945 | gtex_brain_putamen_basal |
| rs4994790 | 7 | 73263375 | CLDN4 | ENSG00000189143.8 | 2.018E-7 | 0 | 49503 | gtex_brain_putamen_basal |
| rs7804928 | 7 | 73264227 | CLDN4 | ENSG00000189143.8 | 4.651E-7 | 0 | 50355 | gtex_brain_putamen_basal |
| rs4717110 | 7 | 73265100 | CLDN4 | ENSG00000189143.8 | 4.619E-7 | 0 | 51228 | gtex_brain_putamen_basal |
| rs4717111 | 7 | 73265177 | CLDN4 | ENSG00000189143.8 | 4.26E-7 | 0 | 51305 | gtex_brain_putamen_basal |
| rs4717112 | 7 | 73265417 | CLDN4 | ENSG00000189143.8 | 4.604E-7 | 0 | 51545 | gtex_brain_putamen_basal |
| rs10271009 | 7 | 73266246 | CLDN4 | ENSG00000189143.8 | 4.562E-7 | 0 | 52374 | gtex_brain_putamen_basal |
| rs36133747 | 7 | 73266323 | CLDN4 | ENSG00000189143.8 | 4.533E-7 | 0 | 52451 | gtex_brain_putamen_basal |
| rs34946565 | 7 | 73266502 | CLDN4 | ENSG00000189143.8 | 7.443E-7 | 0 | 52630 | gtex_brain_putamen_basal |
| rs4341060 | 7 | 73267473 | CLDN4 | ENSG00000189143.8 | 1.459E-6 | 0 | 53601 | gtex_brain_putamen_basal |
| rs4327742 | 7 | 73267726 | CLDN4 | ENSG00000189143.8 | 2.935E-6 | 0 | 53854 | gtex_brain_putamen_basal |
| rs6949053 | 7 | 73269937 | CLDN4 | ENSG00000189143.8 | 1.797E-6 | 0 | 56065 | gtex_brain_putamen_basal |
| rs11764412 | 7 | 73272904 | CLDN4 | ENSG00000189143.8 | 3.222E-6 | 0 | 59032 | gtex_brain_putamen_basal |
| rs4717826 | 7 | 73273361 | CLDN4 | ENSG00000189143.8 | 1.352E-6 | 0 | 59489 | gtex_brain_putamen_basal |
| rs4324825 | 7 | 73275396 | CLDN4 | ENSG00000189143.8 | 2.726E-6 | 0 | 61524 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ABCA8 | 0.84 | 0.81 |
| PIP5K2A | 0.84 | 0.76 |
| KIF13B | 0.83 | 0.74 |
| ERMN | 0.83 | 0.67 |
| NPC1 | 0.83 | 0.77 |
| PLD1 | 0.82 | 0.81 |
| C10orf90 | 0.82 | 0.71 |
| ANLN | 0.82 | 0.74 |
| ENPP2 | 0.82 | 0.68 |
| FOLH1 | 0.82 | 0.67 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C1orf86 | -0.44 | -0.57 |
| AC009133.1 | -0.42 | -0.45 |
| NOL12 | -0.42 | -0.48 |
| SCNM1 | -0.42 | -0.52 |
| NR2C2AP | -0.42 | -0.47 |
| FAM128A | -0.41 | -0.49 |
| MED19 | -0.41 | -0.47 |
| RPL36 | -0.41 | -0.62 |
| CCDC107 | -0.41 | -0.49 |
| DALRD3 | -0.41 | -0.46 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004888 | transmembrane receptor activity | TAS | 9334247 | |
| GO:0005198 | structural molecule activity | IEA | - | |
| GO:0042802 | identical protein binding | ISS | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0009405 | pathogenesis | TAS | 9334247 | |
| GO:0016338 | calcium-independent cell-cell adhesion | ISS | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005923 | tight junction | ISS | Brain (GO term level: 10) | - |
| GO:0005886 | plasma membrane | TAS | 9334247 |9892664 | |
| GO:0005887 | integral to plasma membrane | TAS | 9334247 | |
| GO:0030054 | cell junction | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CELL ADHESION MOLECULES CAMS | 134 | 93 | All SZGR 2.0 genes in this pathway |
| KEGG TIGHT JUNCTION | 134 | 86 | All SZGR 2.0 genes in this pathway |
| KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION | 118 | 78 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CELL COMMUNICATION | 120 | 77 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CELL JUNCTION ORGANIZATION | 56 | 31 | All SZGR 2.0 genes in this pathway |
| REACTOME TIGHT JUNCTION INTERACTIONS | 29 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL JUNCTION ORGANIZATION | 78 | 43 | All SZGR 2.0 genes in this pathway |
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN | 391 | 222 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP | 450 | 256 | All SZGR 2.0 genes in this pathway |
| RODRIGUES NTN1 TARGETS DN | 158 | 102 | All SZGR 2.0 genes in this pathway |
| NAGASHIMA NRG1 SIGNALING UP | 176 | 123 | All SZGR 2.0 genes in this pathway |
| COLDREN GEFITINIB RESISTANCE DN | 230 | 115 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE UP | 530 | 342 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 1 DN | 378 | 231 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL BREAST 4 5WK UP | 271 | 175 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL TGFB1 TARGETS DN | 62 | 44 | All SZGR 2.0 genes in this pathway |
| MUELLER METHYLATED IN GLIOBLASTOMA | 40 | 22 | All SZGR 2.0 genes in this pathway |
| RASHI RESPONSE TO IONIZING RADIATION 2 | 127 | 92 | All SZGR 2.0 genes in this pathway |
| LI AMPLIFIED IN LUNG CANCER | 178 | 108 | All SZGR 2.0 genes in this pathway |
| AIYAR COBRA1 TARGETS DN | 29 | 18 | All SZGR 2.0 genes in this pathway |
| MAINA HYPOXIA VHL TARGETS UP | 6 | 5 | All SZGR 2.0 genes in this pathway |
| MAINA VHL TARGETS DN | 18 | 14 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING VIA SMAD4 DN | 66 | 38 | All SZGR 2.0 genes in this pathway |
| WATTEL AUTONOMOUS THYROID ADENOMA DN | 55 | 29 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 48HR UP | 487 | 286 | All SZGR 2.0 genes in this pathway |
| WU CELL MIGRATION | 184 | 114 | All SZGR 2.0 genes in this pathway |
| ONDER CDH1 TARGETS 2 DN | 464 | 276 | All SZGR 2.0 genes in this pathway |
| SHEPARD CRUSH AND BURN MUTANT UP | 197 | 110 | All SZGR 2.0 genes in this pathway |
| ZUCCHI METASTASIS DN | 44 | 29 | All SZGR 2.0 genes in this pathway |
| SWEET KRAS TARGETS UP | 84 | 51 | All SZGR 2.0 genes in this pathway |
| HALMOS CEBPA TARGETS DN | 46 | 26 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 14HR DN | 298 | 200 | All SZGR 2.0 genes in this pathway |
| YAMAZAKI TCEB3 TARGETS DN | 215 | 132 | All SZGR 2.0 genes in this pathway |
| DAZARD RESPONSE TO UV NHEK UP | 244 | 151 | All SZGR 2.0 genes in this pathway |
| WANG CISPLATIN RESPONSE AND XPC UP | 202 | 115 | All SZGR 2.0 genes in this pathway |
| DAZARD UV RESPONSE CLUSTER G2 | 30 | 18 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 | 482 | 296 | All SZGR 2.0 genes in this pathway |
| YEGNASUBRAMANIAN PROSTATE CANCER | 128 | 60 | All SZGR 2.0 genes in this pathway |
| HUPER BREAST BASAL VS LUMINAL DN | 59 | 44 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
| ELLWOOD MYC TARGETS DN | 40 | 27 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K27ME3 | 269 | 159 | All SZGR 2.0 genes in this pathway |
| COULOUARN TEMPORAL TGFB1 SIGNATURE UP | 109 | 68 | All SZGR 2.0 genes in this pathway |
| YAMASHITA LIVER CANCER STEM CELL UP | 47 | 38 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| DAZARD UV RESPONSE CLUSTER G24 | 28 | 19 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 1HR DN | 222 | 147 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 24HR DN | 505 | 328 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
| DELPUECH FOXO3 TARGETS UP | 68 | 49 | All SZGR 2.0 genes in this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |
| KOHOUTEK CCNT1 TARGETS | 50 | 26 | All SZGR 2.0 genes in this pathway |
| MALIK REPRESSED BY ESTROGEN | 12 | 10 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL DN | 428 | 246 | All SZGR 2.0 genes in this pathway |
| ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF | 222 | 159 | All SZGR 2.0 genes in this pathway |