Gene Page: CRHR2

Summary ?
GeneID1395
SymbolCRHR2
SynonymsCRF-RB|CRF2|CRFR2|HM-CRF
Descriptioncorticotropin releasing hormone receptor 2
ReferenceMIM:602034|HGNC:HGNC:2358|Ensembl:ENSG00000106113|HPRD:03614|
Gene typeprotein-coding
Map location7p14.3
Pascal p-value0.239
Fetal beta-0.134
eGeneCerebellum
Cortex
SupportGPCR SIGNALLING

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
DBX20.730.63
TNNI30.720.62
BARX20.670.66
FCRLA0.630.58
CPE0.630.61
HNMT0.630.67
LIX10.620.60
CTSL20.600.36
PON20.590.59
SLC15A20.590.61
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
UNC84B-0.36-0.43
GAB2-0.35-0.50
NDRG1-0.34-0.44
FAM124A-0.34-0.45
AC005035.1-0.33-0.52
MAP4K4-0.33-0.50
HIP1R-0.33-0.51
KIAA1598-0.33-0.45
RFFL-0.32-0.39
PHLDB1-0.31-0.42

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004930G-protein coupled receptor activityIEA-
GO:0015056corticotrophin-releasing factor receptor activityTAS9717834 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messengerTAS8536644 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007165signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneTAS8536644 
GO:0005887integral to plasma membraneTAS8536644 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 8858All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 12182All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234147All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP 13493All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
SCHLESINGER H3K27ME3 IN NORMAL AND METHYLATED IN CANCER 2821All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203130All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS UP 8550All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 8859All SZGR 2.0 genes in this pathway