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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: CSNK2B

Summary

GeneID

1460

Symbol

CSNK2B

Synonyms

CK2B|CK2N|CSK2B|G5A|MGC138222|MGC138224

Description

casein kinase 2, beta polypeptide

Locus tag

DADB-127H9.2

Gene type

protein-coding

Map location

6p21-p12|6p21.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.033

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.4231

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

APOE

0.91

0.96

AC011427.1

0.90

0.94

METRN

0.87

0.94

TLCD1

0.86

0.94

S100A16

0.85

0.92

HSD17B14

0.85

0.92

PLA2G5

0.84

0.93

AIFM3

0.84

0.90

RAMP1

0.83

0.92

IFI27

0.83

0.90

Top 10 negatively co-expressed genes

ZRANB1

-0.76

-0.84

ARIH2

-0.75

-0.83

UBP1

-0.75

-0.81

C6orf168

-0.75

-0.82

TERF2

-0.75

-0.86

PARG

-0.74

-0.79

RASA1

-0.74

-0.80

NFX1

-0.74

-0.85

RNASEN

-0.74

-0.87

HEATR5B

-0.74

-0.85

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0008605

protein kinase CK2 regulator activity

IEA

GO:0008605

protein kinase CK2 regulator activity

NAS

2666134

GO:0005515

protein binding

IEA

GO:0004674

protein serine/threonine kinase activity

TAS

1856204

GO:0019904

protein domain specific binding

IPI

11984006

GO:0016301

kinase activity

IEA

GO:0042802

identical protein binding

IPI

10094392

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016055

Wnt receptor signaling pathway

IEA

GO:0007165

signal transduction

TAS

2513884

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005956

protein kinase CK2 complex

IEA

GO:0005956

protein kinase CK2 complex

NAS

2666134

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	Affinity Capture-Western	BioGRID	11972058
ARAF	A-RAF \| ARAF1 \| PKS2 \| RAFA1	v-raf murine sarcoma 3611 viral oncogene homolog	-	HPRD,BioGRID	9042965
ATF1	EWS-ATF1 \| FUS/ATF-1 \| TREB36	activating transcription factor 1	Reconstituted Complex	BioGRID	9685505
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	Reconstituted Complex Two-hybrid	BioGRID	10403822
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	BRCA1 is phosphorylated by Casein kinase 2 through a physical interaction with CSNK2B	BIND	10403822
BTF3	BETA-NAC \| BTF3a \| BTF3b \| NACB	basic transcription factor 3	-	HPRD,BioGRID	10094400
CD163	M130 \| MM130	CD163 molecule	-	HPRD,BioGRID	11298324
CDC25B	-	cell division cycle 25 homolog B (S. pombe)	-	HPRD	12527891
CDC34	E2-CDC34 \| UBC3 \| UBE2R1	cell division cycle 34 homolog (S. cerevisiae)	-	HPRD,BioGRID	11546811
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	-	HPRD,BioGRID	10679299
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	Interaction between CK2-beta subunit (PDB ID: 1JWH_D) and CK2-alpha subunit (PDB ID: 1JWH_A).	BIND	11092945 \|11574463
			Interaction between CK2-beta subunit (PDB ID: 1JWH_C) and CK2-alpha subunit (PDB ID: 1JWH_B).	BIND	11092945 \|11574463
			Interaction between CK2-beta subunit (PDB ID: 1JWH_D) and CK2-alpha subunit (PDB ID: 1JWH_B).	BIND	11092945 \|11574463
			-	HPRD,BioGRID	9188720 \|9571630
			Interaction between CK2-beta subunit (PDB ID: 1JWH_C) and CK2-alpha subunit (PDB ID: 1JWH_A).	BIND	11092945 \|11574463
			CK2-alpha subunit interacts with CK2-beta subunit.	BIND	7768894
CSNK2A2	CK2A2 \| CSNK2A1 \| FLJ43934	casein kinase 2, alpha prime polypeptide	-	HPRD,BioGRID	9571630
CSNK2A2	CK2A2 \| CSNK2A1 \| FLJ43934	casein kinase 2, alpha prime polypeptide	CK2-alpha' subunit interacts with CK2-beta subunit.	BIND	7768894
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	casein kinase 2, beta polypeptide	CK2-beta subunit interacts with another copy of itself.	BIND	7768894
			-	HPRD,BioGRID	9188720 \|9571630
			Interaction between CK2-beta subunit (PDB ID: 1JWH_D) and CK2-beta subunit (PDB ID: 1JWH_C).	BIND	11092945 \|11574463
EIF2S2	DKFZp686L18198 \| EIF2 \| EIF2B \| EIF2beta \| MGC8508	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	EIF2beta interacts with CK2beta.	BIND	12901717
FAF1	CGI-03 \| FLJ37524 \| HFAF1s \| UBXD12 \| UBXN3A \| hFAF1	Fas (TNFRSF6) associated factor 1	-	HPRD,BioGRID	10094392 \|11378439 \|11713579
FGF1	AFGF \| ECGF \| ECGF-beta \| ECGFA \| ECGFB \| FGF-alpha \| FGFA \| GLIO703 \| HBGF1	fibroblast growth factor 1 (acidic)	-	HPRD,BioGRID	12145206
FGF2	BFGF \| FGFB \| HBGF-2	fibroblast growth factor 2 (basic)	Reconstituted Complex	BioGRID	12145206
FIBP	FGFIBP \| FIBP-1	fibroblast growth factor (acidic) intracellular binding protein	-	HPRD	12145206
GADD45GIP1	CKBBP2 \| CRIF1 \| MGC4667 \| MGC4758 \| PLINP-1 \| PRG6 \| Plinp1	growth arrest and DNA-damage-inducible, gamma interacting protein 1	-	HPRD,BioGRID	11710515
HNRNPA2B1	DKFZp779B0244 \| FLJ22720 \| HNRNPA2 \| HNRNPB1 \| HNRPA2 \| HNRPA2B1 \| HNRPB1 \| RNPA2 \| SNRPB1	heterogeneous nuclear ribonucleoprotein A2/B1	Reconstituted Complex	BioGRID	10381337
IRF1	IRF-1 \| MAR	interferon regulatory factor 1	CK2-beta interacts with IRF-1 promoter.	BIND	15893730
LYN	FLJ26625 \| JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	Two-hybrid	BioGRID	14667819
LYST	CHS \| CHS1	lysosomal trafficking regulator	-	HPRD,BioGRID	11984006
MAGEB2	DAM6 \| MAGE-XP-2 \| MGC26438	melanoma antigen family B, 2	Affinity Capture-MS	BioGRID	17353931
MAPK14	CSBP1 \| CSBP2 \| CSPB1 \| EXIP \| Mxi2 \| PRKM14 \| PRKM15 \| RK \| SAPK2A \| p38 \| p38ALPHA	mitogen-activated protein kinase 14	-	HPRD	10747897
MBD4	MED1	methyl-CpG binding domain protein 4	Two-hybrid	BioGRID	14667819
MCRS1	ICP22BP \| INO80Q \| MCRS2 \| MSP58 \| P78	microspherule protein 1	Affinity Capture-MS	BioGRID	17353931
NCF1	FLJ79451 \| NCF1A \| NOXO2 \| SH3PXD1A \| p47phox	neutrophil cytosolic factor 1	Two-hybrid	BioGRID	11485312
NCF1C	SH3PXD1C	neutrophil cytosolic factor 1C pseudogene	-	HPRD	11485312
NOLC1	KIAA0035 \| NOPP130 \| NOPP140 \| NS5ATP13 \| P130	nucleolar and coiled-body phosphoprotein 1	-	HPRD,BioGRID	9013635
PIN1	DOD \| UBL5	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	-	HPRD	11940573
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	-	HPRD,BioGRID	10764587
PRNP	ASCR \| CD230 \| CJD \| GSS \| MGC26679 \| PRIP \| PrP \| PrP27-30 \| PrP33-35C \| PrPc \| prion	prion protein	PrPc interacts with CSNK2B (CK2 beta) albeit weakly. This interaction was modeled on a demonstrated interaction between bovine PrPc and human CSNK2B (CK2 beta).	BIND	11062072
RNF7	CKBBP1 \| ROC2 \| SAG	ring finger protein 7	Reconstituted Complex Two-hybrid	BioGRID	11710515
RNPS1	E5.1 \| MGC117332	RNA binding protein S1, serine-rich domain	Affinity Capture-MS	BioGRID	17353931
RPL41	-	ribosomal protein L41	-	HPRD	11710515
RPL41	-	ribosomal protein L41	-	HPRD	9299532 \|11710515
RPL5	MGC117339 \| MSTP030	ribosomal protein L5	-	HPRD	8806611 \|9042965 \|9738462 \|10491318
RPL5	MGC117339 \| MSTP030	ribosomal protein L5	Two-hybrid	BioGRID	8806611 \|9042965 \|11710515 \|14667819
RPS6KB1	PS6K \| S6K \| S6K1 \| STK14A \| p70(S6K)-alpha \| p70-S6K \| p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1	Affinity Capture-Western Reconstituted Complex	BioGRID	16895915
SHMT1	CSHMT \| MGC15229 \| MGC24556 \| SHMT	serine hydroxymethyltransferase 1 (soluble)	-	HPRD	10549165
SHMT2	GLYA \| SHMT	serine hydroxymethyltransferase 2 (mitochondrial)	-	HPRD	10549165
SNCAIP	MGC39814 \| SYPH1	synuclein, alpha interacting protein	CK2B interacts with Synphilin-1.	BIND	14645218
TERF2	TRBF2 \| TRF2	telomeric repeat binding factor 2	CK2-beta interacts with TAF7 promoter.	BIND	15893730
TOP2B	TOPIIB \| top2beta	topoisomerase (DNA) II beta 180kDa	-	HPRD,BioGRID	11710515
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD	10214938
ZNHIT1	CG1I \| ZNFN4A1	zinc finger, HIT type 1	-	HPRD	14667819

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_WNT_SIGNALING_PATHWAY	151	112	All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION	75	53	All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION	134	86	All SZGR genes in this pathway
PID_NFKAPPAB_ATYPICAL_PATHWAY	17	15	All SZGR genes in this pathway
PID_DNA_PK_PATHWAY	16	10	All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY	39	33	All SZGR genes in this pathway
PID_ALK1_PATHWAY	26	21	All SZGR genes in this pathway
PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY	38	29	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS	86	62	All SZGR genes in this pathway
REACTOME_SIGNAL_TRANSDUCTION_BY_L1	34	25	All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	335	193	All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN	180	101	All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN	362	238	All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP	530	342	All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP	117	85	All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN	59	45	All SZGR genes in this pathway
GRASEMANN_RETINOBLASTOMA_WITH_6P_AMPLIFICATION	14	14	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC	108	74	All SZGR genes in this pathway
PATIL_LIVER_CANCER	747	453	All SZGR genes in this pathway
DEN_INTERACT_WITH_LCA5	26	21	All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_DN	245	154	All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_SUBGROUPS	30	20	All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C1	72	45	All SZGR genes in this pathway
CHENG_RESPONSE_TO_NICKEL_ACETATE	45	29	All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED	728	415	All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES	389	245	All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP	605	377	All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_17	181	101	All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP	756	494	All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP	682	440	All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP	242	159	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN	918	550	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-378	58	64	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.