Gene Page: SARDH

Summary ?
GeneID1757
SymbolSARDH
SynonymsBPR-2|DMGDHL1|SAR|SARD|SDH
Descriptionsarcosine dehydrogenase
ReferenceMIM:604455|HGNC:HGNC:10536|Ensembl:ENSG00000123453|HPRD:06831|Vega:OTTHUMG00000020879
Gene typeprotein-coding
Map location9q33-q34
Pascal p-value0.304
Sherlock p-value0.179
Fetal beta0.071
DMG1 (# studies)
eGeneCerebellum
Nucleus accumbens basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
ExpressionMeta-analysis of gene expressionP value: 1.979 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg140018939136562840SARDH3.207E-4-0.5710.04DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CR381670.20.590.18
RGS40.540.59
AL157769.10.530.06
ACSM10.520.16
MAL20.520.50
USH2A0.500.33
ALPK20.500.25
OXR10.500.57
RP11-413E6.10.49-0.07
FER1L60.480.39
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FADS2-0.31-0.33
CENPB-0.30-0.30
BCL7C-0.30-0.44
PKN1-0.29-0.35
METRNL-0.29-0.44
SEMA4B-0.28-0.35
SH2D2A-0.28-0.40
TRAF4-0.28-0.41
SH2B2-0.28-0.40
SH3BP2-0.28-0.40

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004047aminomethyltransferase activityIEA-
GO:0008480sarcosine dehydrogenase activityIEA-
GO:0008480sarcosine dehydrogenase activityTAS10444331 
GO:0009055electron carrier activityTAS10444331 
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008150biological_processND-
GO:0006546glycine catabolic processIEA-
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionIEA-
GO:0005739mitochondrionISS-
GO:0005759mitochondrial matrixIEA-
GO:0005759mitochondrial matrixNAS10444331 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLYCINE SERINE AND THREONINE METABOLISM 3126All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384220All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
CASTELLANO NRAS TARGETS UP 6841All SZGR 2.0 genes in this pathway
CHEBOTAEV GR TARGETS DN 12073All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394258All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261153All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO DN 200112All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447277All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 DN 5132All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE DN 8054All SZGR 2.0 genes in this pathway
MIKKELSEN MEF LCP WITH H3K4ME3 12868All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
MIKKELSEN NPC LCP WITH H3K4ME3 5834All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 16 7947All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 UP 13485All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 14985All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430288All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway