Gene Page: DRD1

Summary ?
GeneID1812
SymbolDRD1
SynonymsDADR|DRD1A
Descriptiondopamine receptor D1
ReferenceMIM:126449|HGNC:HGNC:3020|Ensembl:ENSG00000184845|HPRD:00538|Vega:OTTHUMG00000130557
Gene typeprotein-coding
Map location5q35.1
Pascal p-value0.107
Fetal beta-0.507
eGeneMeta
SupportDOPAMINE
GPCR SIGNALLING
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
ADT:Sun_2012Systematic Investigation of Antipsychotic Drugs and Their TargetsA total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.0276 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 9 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C5orf420.780.80
AADAT0.770.76
TCTN20.770.74
KCTD30.760.80
PROM10.750.75
ZC3H7A0.740.81
REV3L0.740.82
MGEA50.740.78
TOR1B0.740.76
BIVM0.720.77
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
REEP6-0.54-0.49
AF347015.31-0.54-0.65
MT-CO2-0.53-0.65
AF347015.27-0.53-0.62
TSC22D4-0.52-0.56
IFI27-0.51-0.62
CA4-0.51-0.54
FXYD1-0.51-0.59
AF347015.33-0.51-0.60
AIFM3-0.51-0.51

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001590dopamine D1 receptor activityIEAdopamine (GO term level: 10)-
GO:0004872receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007416synaptogenesisISSSynap (GO term level: 6)-
GO:0060158dopamine receptor, phospholipase C activating pathwayIGIdopamine (GO term level: 10)17194762 
GO:0051584regulation of dopamine uptakeICSynap, Neurotransmitter, dopamine (GO term level: 11)8301582 
GO:0051968positive regulation of synaptic transmission, glutamatergicISSneuron, glutamate, Synap, Neurotransmitter (GO term level: 10)-
GO:0007191dopamine receptor, adenylate cyclase activating pathwayIEAdopamine (GO term level: 12)-
GO:0019226transmission of nerve impulseIEAneuron (GO term level: 5)-
GO:0021853cerebral cortex GABAergic interneuron migrationIEAneuron, GABA (GO term level: 14)-
GO:0042053regulation of dopamine metabolic processIEAdopamine (GO term level: 9)-
GO:0001975response to amphetamineIEA-
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messengerIDA1282671 
GO:0007165signal transductionIEA-
GO:0008542visual learningIEA-
GO:0010580activation of adenylate cyclase activity involved in G-protein signalingIDA2144334 
GO:0007631feeding behaviorIEA-
GO:0007628adult walking behaviorIEA-
GO:0007626locomotory behaviorIEA-
GO:0007625grooming behaviorIEA-
GO:0007617mating behaviorIEA-
GO:0042493response to drugIEA-
GO:0030432peristalsisIEA-
GO:0051281positive regulation of release of sequestered calcium ion into cytosolIDA1282671 |7838121 
GO:0030819positive regulation of cAMP biosynthetic processIDA1282671 |7838121 
GO:0030335positive regulation of cell migrationIEA-
GO:0043268positive regulation of potassium ion transportISS-
GO:0051482elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)IDA1282671 
GO:0060134prepulse inhibitionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005624membrane fractionIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0005886plasma membraneIDA11500503 
GO:0005887integral to plasma membraneIC2144334 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 9068All SZGR 2.0 genes in this pathway
BIOCARTA CK1 PATHWAY 1717All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME AMINE LIGAND BINDING RECEPTORS 3833All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 12182All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
LOPES METHYLATED IN COLON CANCER DN 2826All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
BRIDEAU IMPRINTED GENES 6347All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15/16/195/424/497117123m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-203.1106010661Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-216693699m8hsa-miR-216UAAUCUCAGCUGGCAACUGUG
miR-293803861Ahsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-496102810341Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-500423429m8hsa-miR-500AUGCACCUGGGCAAGGAUUCUG
miR-539105510611Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-93.hd/291-3p/294/295/302/372/373/520654660m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU