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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: PTK2B

Summary

GeneID

2185

Symbol

PTK2B

Synonyms

CADTK|CAKB|FADK2|FAK2|FRNK|PKB|PTK|PYK2|RAFTK

Description

PTK2B protein tyrosine kinase 2 beta

Locus tag

Gene type

protein-coding

Map location

8p21.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.031

GSMA_IIE

genome scan meta-analysis (European-ancestry samples)

Psr: 0.00057

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.03086

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.5281

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

NID2

0.84

0.77

NID1

0.81

0.68

LAMC1

0.78

0.71

COL6A3

0.77

0.43

FN1

0.77

0.69

LAMB1

0.77

0.73

COL1A2

0.76

0.52

COL4A1

0.76

0.60

SLC26A2

0.75

0.64

LOXL2

0.75

0.65

Top 10 negatively co-expressed genes

AF347015.31

-0.49

-0.56

AF347015.21

-0.48

-0.59

MT-CO2

-0.48

-0.55

AF347015.27

-0.46

-0.50

FXYD1

-0.45

-0.47

IFI27

-0.45

-0.46

ENHO

-0.45

-0.55

AF347015.8

-0.45

-0.51

AF347015.33

-0.45

-0.47

HIGD1B

-0.45

-0.50

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0004871

signal transducer activity

NAS

10867021

GO:0005515

protein binding

IPI

9020138

GO:0005524

ATP binding

IEA

GO:0004715

non-membrane spanning protein tyrosine kinase activity

TAS

8497321

GO:0016740

transferase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007172

signal complex assembly

TAS

7529876

GO:0006461

protein complex assembly

TAS

10867021

GO:0006468

protein amino acid phosphorylation

TAS

7529876

GO:0006950

response to stress

TAS

8939945

GO:0007165

signal transduction

TAS

7499242 |10867021

GO:0008284

positive regulation of cell proliferation

TAS

10867021

GO:0006915

apoptosis

TAS

10880513

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005856

cytoskeleton

IEA

GO:0005737

cytoplasm

TAS

7499242

GO:0005925

focal adhesion

IEA

GO:0005886

plasma membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ASAP2	AMAP2 \| CENTB3 \| DDEF2 \| FLJ42910 \| KIAA0400 \| PAG3 \| PAP \| Pap-alpha \| SHAG1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	-	HPRD,BioGRID	10022920
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	-	HPRD,BioGRID	8995252
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD,BioGRID	11149930
CCR5	CC-CKR-5 \| CCCKR5 \| CD195 \| CKR-5 \| CKR5 \| CMKBR5	chemokine (C-C motif) receptor 5	-	HPRD	9446638
CD2AP	CMS \| DKFZp586H0519	CD2-associated protein	Affinity Capture-Western	BioGRID	15128873
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	-	HPRD	10329689
DCC	CRC18 \| CRCR1	deleted in colorectal carcinoma	Affinity Capture-Western	BioGRID	15494733
DLG3	KIAA1232 \| MRX \| MRX90 \| NE-Dlg \| NEDLG \| SAP102	discs, large homolog 3 (neuroendocrine-dlg, Drosophila)	-	HPRD,BioGRID	12576483
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	-	HPRD,BioGRID	12576483
EFS	CAS3 \| CASS3 \| EFS1 \| EFS2 \| HEFS \| SIN	embryonal Fyn-associated substrate	-	HPRD	9750131
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	10777553
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	-	HPRD,BioGRID	10713673
EWSR1	EWS	Ewing sarcoma breakpoint region 1	-	HPRD,BioGRID	10322114
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD,BioGRID	9091579 \|9104812 \|10867021
GIT1	-	G protein-coupled receptor kinase interacting ArfGAP 1	Affinity Capture-Western	BioGRID	12629171
GNA13	G13 \| MGC46138	guanine nucleotide binding protein (G protein), alpha 13	-	HPRD,BioGRID	10821841
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	10329689 \|10354709
GRIN2A	NMDAR2A \| NR2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	-	HPRD,BioGRID	11478920
GSN	DKFZp313L0718	gelsolin (amyloidosis, Finnish type)	-	HPRD,BioGRID	12578912
IL7R	CD127 \| CDW127 \| IL-7R-alpha \| IL7RA \| ILRA	interleukin 7 receptor	Affinity Capture-Western	BioGRID	10702271
ITGB2	CD18 \| LAD \| LCAMB \| LFA-1 \| MAC-1 \| MF17 \| MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	-	HPRD,BioGRID	10961871
ITGB3	CD61 \| GP3A \| GPIIIa	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	-	HPRD,BioGRID	11683411
JAK1	JAK1A \| JAK1B \| JTK3	Janus kinase 1 (a protein tyrosine kinase)	-	HPRD,BioGRID	10702271
JAK2	JTK10	Janus kinase 2 (a protein tyrosine kinase)	-	HPRD,BioGRID	11818507
JAK3	JAK-3 \| JAK3_HUMAN \| JAKL \| L-JAK \| LJAK	Janus kinase 3 (a protein tyrosine kinase, leukocyte)	-	HPRD,BioGRID	9512511
KCNA2	HBK5 \| HK4 \| HUKIV \| KV1.2 \| MGC50217 \| MK2 \| NGK1 \| RBK2	potassium voltage-gated channel, shaker-related subfamily, member 2	-	HPRD,BioGRID	11739373
LCK	YT16 \| p56lck \| pp58lck	lymphocyte-specific protein tyrosine kinase	-	HPRD,BioGRID	9091579
LPXN	LDPL	leupaxin	-	HPRD,BioGRID	9565592
LYN	FLJ26625 \| JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	-	HPRD,BioGRID	11311138
MATK	CHK \| CTK \| DKFZp434N1212 \| HHYLTK \| HYL \| HYLTK \| Lsk \| MGC1708 \| MGC2101	megakaryocyte-associated tyrosine kinase	-	HPRD	12063569
MCAM	CD146 \| MUC18	melanoma cell adhesion molecule	-	HPRD	11036077
NEDD9	CAS-L \| CAS2 \| CASL \| CASS2 \| HEF1 \| dJ49G10.2 \| dJ761I2.1	neural precursor cell expressed, developmentally down-regulated 9	-	HPRD,BioGRID	9020138
NPHP1	FLJ97602 \| JBTS4 \| NPH1 \| SLSN1	nephronophthisis 1 (juvenile)	-	HPRD,BioGRID	11493697
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	10797305
PITPNM1	DRES9 \| FLJ44997 \| NIR2 \| PITPNM \| RDGB \| RDGB1 \| RDGBA \| RDGBA1 \| Rd9	phosphatidylinositol transfer protein, membrane-associated 1	-	HPRD,BioGRID	10022914
PITPNM2	KIAA1457 \| NIR3 \| RDGB2 \| RDGBA2	phosphatidylinositol transfer protein, membrane-associated 2	-	HPRD,BioGRID	10022914
PITPNM3	CORD5 \| MGC157740 \| MGC157741 \| NIR1 \| RDGBA3	PITPNM family member 3	-	HPRD,BioGRID	10022914
PRKCD	MAY1 \| MGC49908 \| PKCD \| nPKC-delta	protein kinase C, delta	-	HPRD,BioGRID	11352632
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	Biochemical Activity	BioGRID	9512511
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD,BioGRID	10880513
PTPN12	PTP-PEST \| PTPG1	protein tyrosine phosphatase, non-receptor type 12	-	HPRD,BioGRID	11337490
PTPN6	HCP \| HCPH \| HPTP1C \| PTP-1C \| SH-PTP1 \| SHP-1 \| SHP-1L \| SHP1	protein tyrosine phosphatase, non-receptor type 6	-	HPRD,BioGRID	10521452 \|10747947
PXN	FLJ16691	paxillin	-	HPRD,BioGRID	9099734
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD,BioGRID	8798684 \|10708762 \|10713673
RB1CC1	CC1 \| DRAGOU14 \| FIP200	RB1-inducible coiled-coil 1	Affinity Capture-Western Phenotypic Suppression Reconstituted Complex Two-hybrid	BioGRID	10769033
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	-	HPRD	7544443
SLC2A1	DYT17 \| DYT18 \| GLUT \| GLUT1 \| MGC141895 \| MGC141896 \| PED	solute carrier family 2 (facilitated glucose transporter), member 1	-	HPRD,BioGRID	11007796
SORBS1	CAP \| DKFZp451C066 \| DKFZp586P1422 \| FLAF2 \| FLJ12406 \| KIAA1296 \| R85FL \| SH3D5 \| SH3P12 \| SORB1	sorbin and SH3 domain containing 1	Affinity Capture-Western	BioGRID	15128873
SORBS2	ARGBP2 \| FLJ93447 \| KIAA0777 \| PRO0618	sorbin and SH3 domain containing 2	ArgBP2 interacts with Pyk2.	BIND	15128873
SORBS2	ARGBP2 \| FLJ93447 \| KIAA0777 \| PRO0618	sorbin and SH3 domain containing 2	-	HPRD,BioGRID	15128873
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD	8849729 \|10777553
SRC	ASV \| SRC1 \| c-SRC \| p60-Src		Affinity Capture-Western Reconstituted Complex	BioGRID	8849729 \|10521452 \|10777553
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	-	HPRD,BioGRID	10747947
TGFB1I1	ARA55 \| HIC-5 \| HIC5 \| TSC-5	transforming growth factor beta 1 induced transcript 1	-	HPRD	9422762 \|11856738
TGFB1I1	ARA55 \| HIC-5 \| HIC5 \| TSC-5	transforming growth factor beta 1 induced transcript 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9422762 \|9858471 \|11856738
TLN1	ILWEQ \| KIAA1027 \| TLN	talin 1	-	HPRD,BioGRID	9442086
VAV1	VAV	vav 1 guanine nucleotide exchange factor	-	HPRD,BioGRID	10867021
ZAP70	FLJ17670 \| FLJ17679 \| SRK \| STD \| TZK \| ZAP-70	zeta-chain (TCR) associated protein kinase 70kDa	-	HPRD	10867021

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_CALCIUM_SIGNALING_PATHWAY	178	134	All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY	190	128	All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	137	92	All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	118	78	All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY	101	77	All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY	36	28	All SZGR genes in this pathway
BIOCARTA_BIOPEPTIDES_PATHWAY	45	35	All SZGR genes in this pathway
BIOCARTA_CXCR4_PATHWAY	24	22	All SZGR genes in this pathway
BIOCARTA_IL7_PATHWAY	17	14	All SZGR genes in this pathway
BIOCARTA_PYK2_PATHWAY	31	24	All SZGR genes in this pathway
BIOCARTA_CCR5_PATHWAY	20	16	All SZGR genes in this pathway
BIOCARTA_NKCELLS_PATHWAY	20	13	All SZGR genes in this pathway
BIOCARTA_ACH_PATHWAY	16	13	All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY	37	30	All SZGR genes in this pathway
BIOCARTA_PAR1_PATHWAY	37	28	All SZGR genes in this pathway
SA_PTEN_PATHWAY	17	14	All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY	63	52	All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY	66	53	All SZGR genes in this pathway
PID_AR_PATHWAY	61	46	All SZGR genes in this pathway
PID_AVB3_OPN_PATHWAY	31	29	All SZGR genes in this pathway
PID_IL2_1PATHWAY	55	43	All SZGR genes in this pathway
PID_CXCR4_PATHWAY	102	78	All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY	75	53	All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY	69	57	All SZGR genes in this pathway
PID_ALPHA_SYNUCLEIN_PATHWAY	33	25	All SZGR genes in this pathway
PID_FGF_PATHWAY	55	37	All SZGR genes in this pathway
PID_INTEGRIN_A4B1_PATHWAY	33	24	All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION	120	77	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS	107	86	All SZGR genes in this pathway
REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS	12	10	All SZGR genes in this pathway
REACTOME_IL_2_SIGNALING	41	34	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM	270	204	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP	380	236	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP	418	263	All SZGR genes in this pathway
BIDUS_METASTASIS_DN	161	93	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_UP	197	135	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP	169	127	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP	134	93	All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_EARLY	66	48	All SZGR genes in this pathway
RICKMAN_METASTASIS_DN	261	155	All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP	195	138	All SZGR genes in this pathway
MORI_PRE_BI_LYMPHOCYTE_DN	77	49	All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_DN	160	110	All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP	203	130	All SZGR genes in this pathway
HALMOS_CEBPA_TARGETS_UP	52	34	All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN	128	90	All SZGR genes in this pathway
XU_RESPONSE_TO_TRETINOIN_UP	16	10	All SZGR genes in this pathway
BASSO_CD40_SIGNALING_UP	101	76	All SZGR genes in this pathway
MODY_HIPPOCAMPUS_POSTNATAL	63	50	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP	953	554	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP	783	442	All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3	491	310	All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_DN	37	29	All SZGR genes in this pathway
GAZIN_EPIGENETIC_SILENCING_BY_KRAS	26	16	All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_2G	171	96	All SZGR genes in this pathway
RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP	104	57	All SZGR genes in this pathway
FIRESTEIN_CTNNB1_PATHWAY	33	23	All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK	1210	725	All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_8	49	36	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_UP	56	38	All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP	548	370	All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP	745	475	All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP	199	143	All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF	516	308	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-19	124	130	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	124	130	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-23	515	521	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	515	521	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-323	514	521	1A,m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.