Gene Page: GHRH
Summary ?
| GeneID | 2691 |
| Symbol | GHRH |
| Synonyms | GHRF|GRF|INN |
| Description | growth hormone releasing hormone |
| Reference | MIM:139190|HGNC:HGNC:4265|Ensembl:ENSG00000118702|HPRD:11752|Vega:OTTHUMG00000032413 |
| Gene type | protein-coding |
| Map location | 20q11.2 |
| Pascal p-value | 0.415 |
| Fetal beta | 1.162 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg00222053 | 20 | 35886417 | GHRH | 2.629E-4 | 0.431 | 0.038 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1578978 | chr8 | 118196802 | GHRH | 2691 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AC105206.1 | 0.74 | 0.67 |
| KCNK1 | 0.74 | 0.74 |
| CAMKK1 | 0.74 | 0.67 |
| ANXA11 | 0.74 | 0.72 |
| EXTL1 | 0.74 | 0.75 |
| DNM1 | 0.73 | 0.70 |
| TUBA1 | 0.73 | 0.73 |
| FAIM2 | 0.72 | 0.69 |
| MFSD4 | 0.72 | 0.74 |
| TOLLIP | 0.72 | 0.68 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BCL7C | -0.45 | -0.66 |
| GTF3C6 | -0.44 | -0.53 |
| C9orf46 | -0.43 | -0.62 |
| TRAF4 | -0.41 | -0.60 |
| TUBB2B | -0.41 | -0.56 |
| FADS2 | -0.41 | -0.50 |
| PKN1 | -0.40 | -0.51 |
| C21orf57 | -0.40 | -0.51 |
| KIAA1949 | -0.39 | -0.47 |
| DYNLT1 | -0.39 | -0.63 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005179 | hormone activity | IEA | - | |
| GO:0031770 | growth hormone-releasing hormone receptor binding | IPI | 10537133 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007189 | G-protein signaling, adenylate cyclase activating pathway | IDA | 3008329 | |
| GO:0007267 | cell-cell signaling | TAS | 6192430 | |
| GO:0021984 | adenohypophysis development | IEA | - | |
| GO:0040018 | positive regulation of multicellular organism growth | IMP | 8421089 | |
| GO:0060124 | positive regulation of growth hormone secretion | IDA | 3008329 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0043195 | terminal button | IEA | axon, Synap, Neurotransmitter (GO term level: 8) | - |
| GO:0005576 | extracellular region | IEA | - | |
| GO:0005615 | extracellular space | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | 88 | 58 | All SZGR 2.0 genes in this pathway |
| REACTOME GLUCAGON TYPE LIGAND RECEPTORS | 33 | 22 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA S SIGNALLING EVENTS | 121 | 82 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR LIGAND BINDING | 408 | 246 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| DAZARD RESPONSE TO UV NHEK UP | 244 | 151 | All SZGR 2.0 genes in this pathway |
| DAZARD UV RESPONSE CLUSTER G1 | 67 | 41 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D DN | 270 | 181 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |