Gene Page: MLH3

Summary ?
GeneID27030
SymbolMLH3
SynonymsHNPCC7
DescriptionmutL homolog 3
ReferenceMIM:604395|HGNC:HGNC:7128|Ensembl:ENSG00000119684|HPRD:05094|Vega:OTTHUMG00000171766
Gene typeprotein-coding
Map location14q24.3
Pascal p-value0.467
Fetal beta0.747
DMG1 (# studies)
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg047981581475179846MLH39.355E-46.262DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MICAL10.870.84
ZNF3110.860.86
ZNF1330.860.83
ADAMTS100.860.82
B4GALNT40.850.82
PLSCR30.850.81
NAGK0.840.84
ANKZF10.840.82
RBM50.840.83
QTRT10.840.82
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HLA-F-0.64-0.71
FBXO2-0.62-0.66
CA4-0.62-0.75
ALDOC-0.62-0.70
PTH1R-0.61-0.68
CSRP1-0.60-0.71
TINAGL1-0.60-0.68
C5orf53-0.60-0.70
PTGDS-0.60-0.69
LDHD-0.60-0.65

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003682chromatin bindingIEA-
GO:0003696satellite DNA bindingTAS10615123 
GO:0005515protein bindingNAS12095912 
GO:0005524ATP bindingIEA-
GO:0030983mismatched DNA bindingIEA-
GO:0019237centromeric DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007130synaptonemal complex assemblyIEASynap (GO term level: 11)-
GO:0007131reciprocal meiotic recombinationNAS12095912 
GO:0007140male meiosisIEA-
GO:0007144female meiosis IIEA-
GO:0006298mismatch repairIEA-
GO:0006298mismatch repairNAS12095912 
GO:0008104protein localizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000793condensed chromosomeIEA-
GO:0000795synaptonemal complexIEA-
GO:0005634nucleusTAS10615123 
GO:0005712chiasmaIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MISMATCH REPAIR 2314All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS 11681All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC RECOMBINATION 8662All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP 332228All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP 269146All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230137All SZGR 2.0 genes in this pathway
GNATENKO PLATELET SIGNATURE 4828All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6 153112All SZGR 2.0 genes in this pathway
MATZUK MEIOTIC AND DNA REPAIR 3926All SZGR 2.0 genes in this pathway
MATZUK SPERMATOCYTE 7255All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
RAGHAVACHARI PLATELET SPECIFIC GENES 7046All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317190All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 2HR DN 5535All SZGR 2.0 genes in this pathway