Gene Page: HIST1H1B

Summary ?
GeneID3009
SymbolHIST1H1B
SynonymsH1|H1.5|H1B|H1F5|H1s-3
Descriptionhistone cluster 1, H1b
ReferenceMIM:142711|HGNC:HGNC:4719|Ensembl:ENSG00000184357|HPRD:00821|Vega:OTTHUMG00000016139
Gene typeprotein-coding
Map location6p22.1
Pascal p-value1E-12
Fetal beta0.236
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16836102chr44716366HIST1H1B30090.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AGBL40.640.67
VSNL10.640.67
ARNTL0.630.69
SLC7A80.630.68
FAM47E0.630.63
BMPER0.620.69
RPH3A0.620.70
STBD10.620.67
GRIA40.620.66
C4orf180.620.63
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SH2D2A-0.37-0.43
KIAA1949-0.36-0.32
CARHSP1-0.36-0.45
MYCN-0.35-0.17
SH3BP2-0.35-0.38
ZNF300-0.35-0.22
VASH2-0.35-0.22
AC005393.1-0.35-0.31
SLA-0.35-0.18
RPL18-0.34-0.47

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingNAS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006334nucleosome assemblyNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000786nucleosomeNAS-
GO:0005634nucleusIEA-
GO:0005694chromosomeIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION 1310All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 14894All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE 5437All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514330All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374217All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway