Gene Page: HLA-A

Summary
GeneID  3105
Symbol  HLA-A
Synonyms  HLAA
Description  major histocompatibility complex, class I, A
See related  HGNC:4931|MIM:142800|Ensembl:ENSG00000206503|HPRD:00826|
Locus tag  DAQB-90C11.16
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HLA-DRB50.860.91
CD740.840.88
HLA-DQB10.820.82
HLA-DPA10.790.86
HLA-DRA0.790.84
HLA-DPB10.790.81
ANXA110.740.81
HLA-DMB0.740.77
CTSF0.730.72
ME10.730.80
Top 10 negatively co-expressed genes
KIAA1949-0.59-0.59
TUBB2B-0.58-0.65
SH3BP2-0.58-0.66
NKIRAS2-0.57-0.55
ZNF300-0.57-0.56
AL033532.1-0.56-0.58
ZNF311-0.56-0.59
ZNF551-0.56-0.56
CCDC123-0.56-0.55
AC004017.1-0.56-0.56
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12414957 |17353931 
GO:0032393MHC class I receptor activityNAS1431115 |2437024 |2715640 
|6609814 |8188325 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002474antigen processing and presentation of peptide antigen via MHC class IIEA-
GO:0019882antigen processing and presentationIEA-
GO:0006955immune responseIEA-
GO:0006955immune responseNAS1431115 |2437024 |2715640 
|6609814 |8188325 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000139Golgi membraneEXP15569716 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005887integral to plasma membraneNAS1431115 |2437024 |2715640 
|6609814 |8188325 
GO:0042612MHC class I protein complexIEA-
GO:0031901early endosome membraneEXP15569716 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
B2M-beta-2-microglobulin-HPRD93026 
CALRCRT | FLJ26680 | RO | SSA | cC1qRcalreticulinCRT interacts with HLA-A2. This interaction was modeled on a demonstrated interaction between rabbit CRT and human HLA-A2.BIND15383281 
CD8ACD8 | Leu2 | MAL | p32CD8a molecule-HPRD,BioGRID9177355 |10809759|10809759 
COPB1COPB | DKFZp761K102 | FLJ10341coatomer protein complex, subunit beta 1Affinity Capture-WesternBioGRID11884415 
COPGCOPG1 | FLJ21068coatomer protein complex, subunit gammaAffinity Capture-WesternBioGRID11884415 
DERL1DER-1 | DER1 | FLJ13784 | FLJ42092 | MGC3067 | PRO2577Der1-like domain family, member 1-HPRD,BioGRID15215855 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD,BioGRID10593938 
KIR3DL2CD158K | MGC125321 | NKAT4 | NKAT4B | p140killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2-HPRD,BioGRID8617928 |8760804 
LILRB1CD85 | CD85J | FLJ37515 | ILT2 | LIR-1 | LIR1 | MIR-7 | MIR7leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1-HPRD,BioGRID12897781 
LILRB2CD85D | ILT4 | LILRA6 | LIR-2 | LIR2 | MIR-10 | MIR10leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2-HPRD,BioGRID9531263 |12853576 
MAGEA1MAGE1 | MGC9326melanoma antigen family A, 1 (directs expression of antigen MZ2-E)Reconstituted ComplexBioGRID8647853 
MAGEA4MAGE-41 | MAGE-X2 | MAGE4 | MAGE4A | MAGE4B | MGC21336melanoma antigen family A, 4-HPRD,BioGRID11502003 
TAP1ABC17 | ABCB2 | APT1 | D6S114E | FLJ26666 | FLJ41500 | PSF1 | RING4 | TAP1*0102N | TAP1Ntransporter 1, ATP-binding cassette, sub-family B (MDR/TAP)Affinity Capture-WesternBioGRID11884415 
TAPBPNGS17 | TAPA | TPN | TPSN | tapasinTAP binding protein (tapasin)-HPRD8769474 
Affinity Capture-WesternBioGRID11884415 
TRA@FLJ22602 | MGC117436 | MGC22624 | MGC23964 | MGC71411 | TCRA | TCRD | TRAT cell receptor alpha locus-HPRD,BioGRID9586631 
TRB@TCRB | TRBT cell receptor beta locusCo-crystal StructureBioGRID9586631 
UGCGL1FLJ23671 | FLJ23796 | HUGT1UDP-glucose ceramide glucosyltransferase-like 1Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_CELL_ADHESION_MOLECULES_CAMS 13493All SZGR genes in this pathway
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 8965All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_TYPE_I_DIABETES_MELLITUS 4438All SZGR genes in this pathway
KEGG_AUTOIMMUNE_THYROID_DISEASE 5349All SZGR genes in this pathway
KEGG_ALLOGRAFT_REJECTION 3834All SZGR genes in this pathway
KEGG_GRAFT_VERSUS_HOST_DISEASE 4231All SZGR genes in this pathway
KEGG_VIRAL_MYOCARDITIS 7358All SZGR genes in this pathway
BIOCARTA_CTL_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_NKCELLS_PATHWAY 2013All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY 5342All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION 105All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 7648All SZGR genes in this pathway
REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY 97All SZGR genes in this pathway
REACTOME_ER_PHAGOSOME_PATHWAY 6140All SZGR genes in this pathway
REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS 2112All SZGR genes in this pathway
REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL 7037All SZGR genes in this pathway
REACTOME_INTERFERON_GAMMA_SIGNALING 6348All SZGR genes in this pathway
REACTOME_INTERFERON_ALPHA_BETA_SIGNALING 6450All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING 159116All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS 2819All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC 2117All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
WANG_ESOPHAGUS_CANCER_VS_NORMAL_UP 12172All SZGR genes in this pathway
EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_UP 207128All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_UP 10869All SZGR genes in this pathway
ALCALA_APOPTOSIS 8860All SZGR genes in this pathway
MANTOVANI_VIRAL_GPCR_SIGNALING_DN 4937All SZGR genes in this pathway
LIU_NASOPHARYNGEAL_CARCINOMA 7038All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_UP 3532All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
IIZUKA_LIVER_CANCER_PROGRESSION_L0_L1_DN 2114All SZGR genes in this pathway
DER_IFN_ALPHA_RESPONSE_UP 7448All SZGR genes in this pathway
WIELAND_UP_BY_HBV_INFECTION 10166All SZGR genes in this pathway
DER_IFN_BETA_RESPONSE_UP 10267All SZGR genes in this pathway
SANA_RESPONSE_TO_IFNG_UP 7850All SZGR genes in this pathway
SANA_TNF_SIGNALING_UP 8356All SZGR genes in this pathway
SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_DN 4528All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
DER_IFN_GAMMA_RESPONSE_UP 7145All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_UP 5233All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
KIM_LRRC3B_TARGETS 3024All SZGR genes in this pathway
PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN 4938All SZGR genes in this pathway
GAURNIER_PSMD4_TARGETS 7355All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
WUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_DN 127All SZGR genes in this pathway
LEE_EARLY_T_LYMPHOCYTE_DN 5736All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
KUROKAWA_LIVER_CANCER_EARLY_RECURRENCE_DN 76All SZGR genes in this pathway
SENGUPTA_EBNA1_ANTICORRELATED 17385All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway


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