Gene Page: APOC3

Summary ?
GeneID345
SymbolAPOC3
SynonymsAPOCIII|HALP2
Descriptionapolipoprotein C-III
ReferenceMIM:107720|HGNC:HGNC:610|Ensembl:ENSG00000110245|HPRD:00132|Vega:OTTHUMG00000046115
Gene typeprotein-coding
Map location11q23.3
Pascal p-value0.618
Fetal beta0.05

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.006 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CST30.910.96
AC011427.10.860.93
SLC7A100.850.91
HSD17B140.840.91
METRN0.820.91
AIFM30.820.90
TSC22D40.810.90
S100A160.800.91
GATSL30.790.76
TLCD10.790.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C6orf168-0.75-0.83
SPATS2-0.73-0.85
EIF4ENIF1-0.73-0.81
PREP-0.72-0.81
RASA1-0.72-0.79
ARIH2-0.72-0.82
TERF2-0.72-0.84
ZNF329-0.72-0.83
UBP1-0.72-0.79
ZRANB1-0.72-0.82

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005543phospholipid bindingIDA4066713 |11060345 
GO:0005319lipid transporter activityIEA-
GO:0030234enzyme regulator activityIDA11060345 
GO:0015485cholesterol bindingIC11162594 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayIDA16443932 
GO:0016042lipid catabolic processIEA-
GO:0006869lipid transportIEA-
GO:0033344cholesterol effluxIDA11162594 |16443932 
GO:0051005negative regulation of lipoprotein lipase activityIDA11060345 
GO:0042157lipoprotein metabolic processIEA-
GO:0019433triacylglycerol catabolic processIDA11060345 
GO:0034375high-density lipoprotein particle remodelingIMP17438339 
GO:0032488Cdc42 protein signal transductionIDA16443932 
GO:0033700phospholipid effluxIDA11162594 
GO:0045717negative regulation of fatty acid biosynthetic processIDA11060345 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP4345202 
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA11060345 
GO:0034366spherical high-density lipoprotein particleIDA17438339 
GO:0034363intermediate-density lipoprotein particleIDA17336988 
GO:0034361very-low-density lipoprotein particleIDA16935699 
GO:0042627chylomicronIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PPAR SIGNALING PATHWAY 6947All SZGR 2.0 genes in this pathway
REACTOME HDL MEDIATED LIPID TRANSPORT 1512All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT 4637All SZGR 2.0 genes in this pathway
REACTOME LIPOPROTEIN METABOLISM 2824All SZGR 2.0 genes in this pathway
REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT 1615All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS TEMPORAL DN 2516All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP 7049All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE DN 8054All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 8859All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway