Gene Page: CXCR2
Summary ?
| GeneID | 3579 |
| Symbol | CXCR2 |
| Synonyms | CD182|CDw128b|CMKAR2|IL8R2|IL8RA|IL8RB |
| Description | C-X-C motif chemokine receptor 2 |
| Reference | MIM:146928|HGNC:HGNC:6027|Ensembl:ENSG00000180871|HPRD:00907|Vega:OTTHUMG00000133107 |
| Gene type | protein-coding |
| Map location | 2q35 |
| Pascal p-value | 0.652 |
| Fetal beta | -0.223 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | IEA | - | |
| GO:0004918 | interleukin-8 receptor activity | IDA | 10820279 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007200 | G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) | IDA | 10438939 | |
| GO:0006968 | cellular defense response | IDA | 10725748 | |
| GO:0008284 | positive regulation of cell proliferation | IDA | 10438939 | |
| GO:0006954 | inflammatory response | TAS | 9725262 | |
| GO:0006935 | chemotaxis | IDA | 10725748 | |
| GO:0006915 | apoptosis | IEA | - | |
| GO:0042119 | neutrophil activation | IDA | 10878382 | |
| GO:0030593 | neutrophil chemotaxis | IDA | 10820279 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005622 | intracellular | IDA | 10878382 | |
| GO:0009986 | cell surface | IDA | 10878382 | |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 10438939 | |
| GO:0042629 | mast cell granule | IDA | 9725262 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ARRB1 | ARB1 | ARR1 | arrestin, beta 1 | - | HPRD,BioGRID | 11170396 |
| CXCL1 | FSP | GRO1 | GROa | MGSA | MGSA-a | NAP-3 | SCYB1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | - | HPRD | 1379593 |8550564 |8702798 |8940121 |
| CXCL1 | FSP | GRO1 | GROa | MGSA | MGSA-a | NAP-3 | SCYB1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | in vivo | BioGRID | 1379593 |8702798 |8940121 |
| CXCL2 | CINC-2a | GRO2 | GROb | MGSA-b | MIP-2a | MIP2 | MIP2A | SCYB2 | chemokine (C-X-C motif) ligand 2 | - | HPRD,BioGRID | 8702798 |9260277 |
| CXCL3 | CINC-2b | GRO3 | GROg | MIP-2b | MIP2B | SCYB3 | chemokine (C-X-C motif) ligand 3 | - | HPRD,BioGRID | 8702798 |
| CXCL5 | ENA-78 | SCYB5 | chemokine (C-X-C motif) ligand 5 | - | HPRD,BioGRID | 8702798 |9692902 |
| CXCL6 | CKA-3 | GCP-2 | GCP2 | SCYB6 | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | - | HPRD,BioGRID | 9692902 |10593335 |
| GNA15 | GNA16 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | - | HPRD,BioGRID | 9843397 |
| GTF3A | AP2 | TFIIIA | general transcription factor IIIA | Affinity Capture-Western | BioGRID | 11170396 |
| IL8 | CXCL8 | GCP-1 | GCP1 | LECT | LUCT | LYNAP | MDNCF | MONAP | NAF | NAP-1 | NAP1 | interleukin 8 | - | HPRD,BioGRID | 8702798 |9464567 |
| IL8RB | CD182 | CDw128b | CMKAR2 | CXCR2 | IL8R2 | IL8RA | interleukin 8 receptor, beta | - | HPRD,BioGRID | 12888558 |
| MYO5B | KIAA1119 | myosin VB | Affinity Capture-Western | BioGRID | 15004234 |
| PPBP | B-TG1 | Beta-TG | CTAP-III | CTAP3 | CTAPIII | CXCL7 | LA-PF4 | LDGF | MDGF | NAP-2 | PBP | SCYB7 | TC1 | TC2 | TGB | TGB1 | THBGB | THBGB1 | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | - | HPRD,BioGRID | 8195702 |8702798 |
| RAB11FIP2 | KIAA0941 | Rab11-FIP2 | nRip11 | RAB11 family interacting protein 2 (class I) | - | HPRD,BioGRID | 15004234 |
| RGS12 | DKFZp761K1617 | DKFZp761K1817 | regulator of G-protein signaling 12 | - | HPRD | 9651375 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | 267 | 161 | All SZGR 2.0 genes in this pathway |
| KEGG CHEMOKINE SIGNALING PATHWAY | 190 | 128 | All SZGR 2.0 genes in this pathway |
| KEGG ENDOCYTOSIS | 183 | 132 | All SZGR 2.0 genes in this pathway |
| KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION | 68 | 44 | All SZGR 2.0 genes in this pathway |
| ST GRANULE CELL SURVIVAL PATHWAY | 27 | 23 | All SZGR 2.0 genes in this pathway |
| PID IL8 CXCR2 PATHWAY | 34 | 26 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | 188 | 108 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 305 | 177 | All SZGR 2.0 genes in this pathway |
| REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | 57 | 27 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA I SIGNALLING EVENTS | 195 | 114 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR LIGAND BINDING | 408 | 246 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN MLL SIGNATURE 1 UP | 380 | 236 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN MLL SIGNATURE 2 UP | 418 | 263 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE EPIDERMIS UP | 293 | 179 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
| HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
| THEILGAARD NEUTROPHIL AT SKIN WOUND DN | 225 | 163 | All SZGR 2.0 genes in this pathway |
| KUMAR TARGETS OF MLL AF9 FUSION | 405 | 264 | All SZGR 2.0 genes in this pathway |
| LIAN LIPA TARGETS 6M | 74 | 47 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 24HR DN | 148 | 102 | All SZGR 2.0 genes in this pathway |
| KAYO AGING MUSCLE UP | 244 | 165 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| LIAN LIPA TARGETS 3M | 59 | 36 | All SZGR 2.0 genes in this pathway |
| YOKOE CANCER TESTIS ANTIGENS | 38 | 22 | All SZGR 2.0 genes in this pathway |
| VART KSHV INFECTION ANGIOGENIC MARKERS DN | 138 | 92 | All SZGR 2.0 genes in this pathway |
| MARTINELLI IMMATURE NEUTROPHIL DN | 13 | 9 | All SZGR 2.0 genes in this pathway |
| MIZUKAMI HYPOXIA UP | 12 | 12 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| KUROZUMI RESPONSE TO ONCOCYTIC VIRUS | 44 | 30 | All SZGR 2.0 genes in this pathway |
| KUROZUMI RESPONSE TO ONCOCYTIC VIRUS AND CYCLIC RGD | 21 | 15 | All SZGR 2.0 genes in this pathway |
| ZWANG EGF INTERVAL DN | 214 | 124 | All SZGR 2.0 genes in this pathway |