SZGR2

Summary ?

GeneID	3768
Symbol	KCNJ12
Synonyms	IRK-2\|IRK2\|KCNJN1\|Kir2.2\|Kir2.2v\|hIRK\|hIRK1\|hkir2.2x\|kcnj12x
Description	potassium voltage-gated channel subfamily J member 12
Reference	MIM:602323\|HGNC:HGNC:6258\|Ensembl:ENSG00000184185\|HPRD:09083\|Vega:OTTHUMG00000132039
Gene type	protein-coding
Map location	17p11.2
Pascal p-value	0.17
Fetal beta	-3.314
DMG	1 (# studies)
eGene	Myers' cis & trans
Support	EXCITABILITY

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.006

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg26857910	17	21279619	KCNJ12	3.76E-6	-0.391	0.009	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs16829545	chr2	151977407	KCNJ12	3768		2.846E-4		trans
rs16955618	chr15	29937543	KCNJ12	3768		2.319E-4		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005242	inward rectifier potassium channel activity	IEA		-
GO:0005242	inward rectifier potassium channel activity	TAS		7859381
GO:0005244	voltage-gated ion channel activity	IEA		-
GO:0008200	ion channel inhibitor activity	TAS		8647284
GO:0015459	potassium channel regulator activity	TAS		8647284
GO:0030955	potassium ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008015	blood circulation	NAS		7859381
GO:0008016	regulation of heart contraction	TAS		7859381
GO:0006811	ion transport	IEA		-
GO:0006813	potassium ion transport	IEA		-
GO:0006813	potassium ion transport	TAS		7859381 \|8647284
GO:0006936	muscle contraction	TAS		7859381
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016020	membrane	IEA		-
GO:0016021	integral to membrane	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABLIM1	ABLIM \| DKFZp781D0148 \| FLJ14564 \| KIAA0059 \| LIMAB1 \| LIMATIN \| MGC1224	actin binding LIM protein 1	-	HPRD,BioGRID	15024025
APBA1	D9S411E \| MINT1 \| X11 \| X11A \| X11ALPHA	amyloid beta (A4) precursor protein-binding, family A, member 1	-	HPRD,BioGRID	14960569 \|15024025
CASK	CAGH39 \| CMG \| FLJ22219 \| FLJ31914 \| LIN2 \| MICPCH \| TNRC8	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	-	HPRD,BioGRID	14960569 \|15024025
DLG1	DKFZp761P0818 \| DKFZp781B0426 \| DLGH1 \| SAP97 \| dJ1061C18.1.1 \| hdlg	discs, large homolog 1 (Drosophila)	-	HPRD,BioGRID	5024025 \|11181181 \|14960569
DLG2	DKFZp781D1854 \| DKFZp781E0954 \| FLJ37266 \| MGC131811 \| PSD-93	discs, large homolog 2, chapsyn-110 (Drosophila)	-	HPRD,BioGRID	15024025
DLG3	KIAA1232 \| MRX \| MRX90 \| NE-Dlg \| NEDLG \| SAP102	discs, large homolog 3 (neuroendocrine-dlg, Drosophila)	-	HPRD,BioGRID	15024025
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	-	HPRD,BioGRID	15024025
DMD	BMD \| CMD3B \| DXS142 \| DXS164 \| DXS206 \| DXS230 \| DXS239 \| DXS268 \| DXS269 \| DXS270 \| DXS272	dystrophin	-	HPRD,BioGRID	15024025
DTNA	D18S892E \| DRP3 \| DTN \| FLJ96209 \| LVNC1	dystrobrevin, alpha	-	HPRD,BioGRID	15024025
LIN7A	LIN-7A \| LIN7 \| MALS-1 \| MGC148143 \| TIP-33 \| VELI1	lin-7 homolog A (C. elegans)	-	HPRD,BioGRID	14960569 \|15024025
LIN7B	LIN-7B \| MALS-2 \| MALS2 \| VELI2	lin-7 homolog B (C. elegans)	Affinity Capture-Western Reconstituted Complex	BioGRID	14960569 \|15024025
LIN7C	FLJ11215 \| LIN-7-C \| LIN-7C \| MALS-3 \| MALS3 \| VELI3	lin-7 homolog C (C. elegans)	Affinity Capture-MS Affinity Capture-Western Reconstituted Complex	BioGRID	14960569 \|15024025
MPP6	PALS2 \| VAM-1 \| VAM1 \| p55T	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	Affinity Capture-MS	BioGRID	15024025
SNTA1	SNT1 \| TACIP1 \| dJ1187J4.5	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	-	HPRD,BioGRID	15024025
SNTB1	59-DAP \| A1B \| BSYN2 \| DAPA1B \| FLJ22442 \| MGC111389 \| SNT2 \| SNT2B1 \| TIP-43	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	-	HPRD,BioGRID	15024025
SNTB2	D16S2531E \| EST25263 \| SNT2B2 \| SNT3 \| SNTL	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	-	HPRD,BioGRID	15024025

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	137	110	All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	25	17	All SZGR 2.0 genes in this pathway
REACTOME GABA B RECEPTOR ACTIVATION	38	26	All SZGR 2.0 genes in this pathway
REACTOME GABA RECEPTOR ACTIVATION	52	40	All SZGR 2.0 genes in this pathway
REACTOME POTASSIUM CHANNELS	98	68	All SZGR 2.0 genes in this pathway
REACTOME INWARDLY RECTIFYING K CHANNELS	31	20	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS	355	243	All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS	205	145	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 40 HELA	42	29	All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6	469	239	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	1021	1027	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	1020	1027	1A,m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	1020	1027	1A,m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-125/351	800	806	m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	800	806	m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-132/212	427	433	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	427	433	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-143	2356	2362	m8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-145	3131	3137	m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-29	3002	3008	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-30-5p	430	437	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: KCNJ12